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Background SLE is a systemic autoimmune disease with a large number of common risk gene variants, but several rare gene variants can cause monogenic SLE. The relationship between common and rare variants in SLE is unclear. We therefore investigated the occurrence of rare deleterious variants in patients with childhood-onset SLE (cSLE) and adult-onset SLE (aSLE) and compared the frequency of these
This thesis investigates particle sorting in deterministic lateral displacement (DLD) microfluidic devices, with a focus on how particle size and shape influence sorting behavior. A broad range of synthetic and biological particles were studied, including polystyrene particles, fabricated silicon-based structures, and bacterial samples with diverse physical properties.While DLD has traditionally b
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gu
Objective To compare longitudinal speech outcomes at ages 5 and 10 years in foreign-born and Swedish-born children with cleft palate with or without cleft lip (CP ± L), and assess impact of cleft type, additional diagnosed conditions, sex, and age at completed primary palatal surgery.DesignLongitudinal, registry-based cohort study.SettingRegional public care university hospitals in Sweden.Particip
The metastatic potential of cancer cells is closely linked to their mechanical properties, and changes in these properties often correspond to the progression of the disease. To study how mechanical factors such as cell size and deformability influence the spread of cancer and the surrounding extracellular matrix, it is crucial that cancer cell populations be sorted in relevant subpopulations with
The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,
Background: Severe Alpha-1-Antitrypsin deficiency (AATD), phenotype PiZZ, is a leading cause of liver disease in neonates, children, and adults. Nevertheless, the prevalence of liver disease and mortality within PiZZ adults remains unclear. Between 1972 and 1974, a cohort of 129 individuals with severe AATD (PiZZ) was identified through the Swedish national screening of 200,000 newborns. The cohor
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, insulin resistance, dyslipidemia, and hypertension. Its association with venous thromboembolism (VTE) has been inconsistently reported. We investigated the association between MetS and VTE, and the influence of sex and abdominal obesity. We included 12,788 middle-aged and older adults from the re-ex
The formation of InSb quantum dots (QDs) embedded in an InAs matrix grown by molecular beam epitaxy (MBE) was studied parametrically. In particular, the effect of the sequence of the change of As2 dimers and Sb2 on the distribution of As and Sb at the InSb-QDs/InAs interface was investigated by cross-sectional transmission electron microscopy (TEM). It was shown that additional As2 above the InSb
Optimization and electrical control of photovoltaic (PV) and proton exchange membrane (PEM) electrolyzer systems are critical for efficient, scalable hydrogen production. Static coupling methods employ fixed electrical interconnections between PV arrays and the PEM stack, which cannot adapt to fluctuating irradiance or temperature. To overcome this, we propose an adaptive reconfiguration optimizat
Context: Newly discovered biomarkers ideally should prove clinical usefulness, provide additional detection, staging, and prognosis information to improve individual risk assessment, and potentially permit targeted cancer therapy. Objective: To review, display, and evaluate the current evidence regarding the biologic and analytic approach of urinary prostate cancer gene 3 (PCA3) in prostate cancer
Quality Assurance Report – Malmö Art Academy 2018-19 1 Table of Contents 1. EVALUATION CRITERIA 2 1.1 EXTERNAL ASSESSMENT PANEL AND TIMELINE 3 2. INTRODUCTION TO MALMÖ ART ACADEMY 4 2.1 KEY INFORMATION ABOUT MALMÖ ART ACADEMY 6 3. BACHELOR OF FINE ARTS PROGRAMME (1ST CYCLE) 7 3.1 CONTENT AND STRUCTURE OF THE BFA PROGRAMME AT MALMÖ ART ACADEMY 7 3.2 METHODS, COURSES AND THE ANNUAL EXHIBITION 9 3.3
https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2020-10/underlag_arende_binder.pdf - 2026-05-08
Microsoft Word - Thesis A-L Ikkala.doc 1 The Upcoming REDD Mechanism in the Light of Existing Forest Instruments by Anna-Leena Ikkala Supervisor Dr. Anne Jerneck (LUCSUS) A Thesis Submitted to Lund University in partial fulfilment of the requirements for the degree of MASTER OF SCIENCE International Master’s Programme in Environmental Studies and Sustainability Science (LUMES) Lund University Cent
https://www.lumes.lu.se/sites/lumes.lu.se/files/ikkala_anna-lena_0.pdf - 2026-05-08
Introduction LUMES Master Thesis 2002-2003 How Can Systems Thinking Be Used to Support Rural Development Decisions in Latvia Submitted in partial fulfilment of the requirements of the International Master in Environmental Sciences degree, Lund University, Sweden Submitted by: Yuri Kondratenko Ganu 4-10 Riga LV-1010 Latvia Phone: +371 7 33 10 97 jurijs.kondratenko.197@student.lu.se Supervisor: Ande
https://www.lumes.lu.se/sites/lumes.lu.se/files/kondratenko_yuri.pdf - 2026-05-08
OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METHODS We conducted summary-level univariable and multivariable Mendelian randomization (MR) analyses in 921,908 participants to investigate the effect of lowering
Background: Accumulating evidence suggests that statins have a beneficial effect on breast cancer prognosis. Previous studies have reported a positive association between statin use and breast cancer survival; however, the relationship between statin use and patterns of breast cancer recurrence remains unclear. Patients and methods: We identified all Malmö Diet and Cancer Study (MDCS) participants
Objectives To study the value of combining individual- and neighborhood-level sociodemographic data to predict study participation and assess the effects of baseline selection on the distribution of metabolic risk factors and lifestyle factors in the Swedish CardioPulmonary bioImage Study (SCAPIS). Methods We linked sociodemographic register data to SCAPIS participants (n = 30,154, ages: 50-64 yea
BACKGROUND One of the most challenging tasks of modern biology concerns the real-time tracking and quantification of mRNA expression in living cells. On this matter, a novel platform called SmartFlareTM has taken advantage of fluorophore-linked nanoconstructs for targeting RNA transcripts. Although fluorescence emission does not account for the spatial mRNA distribution, NanoFlare technology has g
Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with
