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Diagnostic contribution of multi-frequency vibrometry to detection of peripheral neuropathy in type 1 diabetes mellitus compared with nerve conduction studies

Aim The aim was to assess the use of multi-frequency vibrometry (MFV) in detecting diabetic peripheral neuropathy (DPN) in type 1 diabetes in comparison to nerve conduction studies (NCS) and neurothesiometer (NT). Our objectives were to examine how VPTs correlated with NCS parameters, evaluate the efficacy of MFV in distinguishing DPN as well as to investigate whether MFV procedure could be based

Separation of biomolecules using Open-Loop Non-Isocratic Simulated moving bed (SMB) technology

In biotechnological industries, downstream processing is a bottleneck in the complete production process. There is a wish to reduce the costs and therefore one tries to operate separation technology in continuous mode. Conventional SMB is a continuous countercurrent separation process, which is based on mathematical modeling and simulation studies for separation of binary mixtures of components.

When and Why Did Sweden Lag Behind? 'Eurosclerosis' Revisited

The conventional view is that Sweden transformed its economy and institutions more slowly than other countries after the structural crisis of the late 1970s, and this is held as an explanation for Sweden’s poor economic growth thereafter. This paper questions that view in several aspects. First, it points out that Sweden has performed comparatively well since the end of the EMS crisis. Second, Swe

Quantitative Time-Resolved Fluorescence Imaging of Androgen Receptor and Prostate-Specific Antigen in Prostate Tissue Sections

Androgen receptor (AR) and prostate-specific antigen (PSA) are expressed in the prostate and are involved in prostate cancer (PCa). The aim of this study was to develop reliable protocols for reproducible quantification of AR and PSA in benign and malignant prostate tissue using time-resolved fluorescence (TRF) imaging techniques. AR and PSA were detected with TRF in tissue microarrays from 91 PCa

How Firms Adapt and Interact in Open Source Ecosystems: Analyzing Stakeholder Influence and Collaboration Patterns

[Context and motivation] Ecosystems developed as Open Source Software (OSS) are considered to be highly innovative and reactive to new market trends due to their openness and wide-ranging contributor base. Participation in OSS often implies opening up of the software development process and exposure towards new stakeholders. [Question/Problem] Firms considering to engage in such an environment sho

Diversity of soil microbial communities: In the perspective of targeting functional genes

Abstract Intensive land use in agriculture can lead to higher loss of biodiversity in soils and subsequently carbon due to tillage and application of pesticides and fertilizers. The microbial communities are pivotal to ecosystem processes in soil such as nutrient cycling, soil formation and plant productivity and thus are affected by land use. The main aim of this thesis is to understand the effe

Protein identification by in-gel digestion, high-performance liquid chromatography, and mass spectrometry: peptide analysis by complementary ionization techniques

A biologically active protein fraction was isolated from rabbit intestine, purified by one-dimensional SDS-PAGE and stained with Coomassie Brilliant Blue. A predominant band of approximately 110-130 kDa was excised and digested in-gel with trypsin. The resulting peptides were extracted then separated by microbore reversed-phase high-performance liquid chromatography (HPLC). Mass spectrometric data

Understanding the urban ecosystem : interactions between plants, animals, and people

Cities are the pinnacle of human change to the environment, creating unique types of ecosystems which present many challenges to local organisms: habitat fragmentation, introduced species, and various pollutants. Being crucibles of anthropogenic effects, urban ecosystems offer opportunities to understand how humans impact nature. Moreover, since a majority of the world’s population resides in citiCities are the pinnacle of human change to the environment, creating unique types of ecosystems which present many challenges to local organisms: habitat fragmentation, introduced species, and various pollutants. Being crucibles of anthropogenic effects, urban ecosystems offer opportunities to understand how humans impact nature. Moreover, since a majority of the world’s population resides in citi

Spatiotemporal and microstructural characterization of heterotopic ossification in healing rat Achilles tendons

Achilles tendon rupture is a common debilitating medical condition. The healing process is slow and can be affected by heterotopic ossification (HO), which occurs when pathologic bone-like tissue is deposited instead of the soft collagenous tendon tissue. Little is known about the temporal and spatial progression of HO during Achilles tendon healing. In this study we characterize HO deposition, mi

Stratified Genetic Analysis Reveals Sex Differences In MPO-ANCA-associated Vasculitis

OBJECTIVE: To identify and genetically characterize subgroups of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) based on sex and ANCA subtype.METHODS: A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1088 Scandinavian cases with AAV and 1589 controls was stratified for sex and ANCA subtype and analysed for ass