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Optogenetics is highly useful to stimulate or inhibit defined neuronal populations and is often used together with electrophysiological recordings. Due to poor penetration of light in tissue, there is a need for biocompatible wave guides. Glass wave guides are relatively stiff and known to cause glia reaction that likely influence the activity in the remaining neurons. We developed highly flexible
We study experimentally and with wave optics modelling the absorption of light in CsPbBr3perovskite nanowire arrays fabricated into periodic pores of an anodized aluminum oxide matrix, for nanowire diameters from 30 to 360 nm. First, we find that all the light that couples into the array can be absorbed by the nanowires at sufficient nanowire length. This behavior is in strong contrast to the expe
Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population. Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC).
In the present study, three-dimensional direct numerical simulations (DNS) of experimental ammonia/air premixed jet flames with different turbulent intensities were performed. The DNS results were first compared to the measurements with good agreements. Based on the DNS data, the turbulent flame structure, stabilization mechanism and NO emission characteristics of the flames were investigated. It
Developments in ambulatory electrocardiogram (ECG) technology have led to vast amounts of ECG data that currently need to be interpreted by human technicians. Here we tested an artificial intelligence (AI) algorithm for direct-to-physician reporting of ambulatory ECGs. Beat-by-beat annotation of 14,606 individual ambulatory ECG recordings (mean duration = 14 ± 10 days) was performed by certified E
Understanding the mechanisms governing interfacial charge transfer in photoactive layer is crucial for optimizing photogenerated charge separation efficiency. In this study, the interfacial charge transfer process is regulated by applying external electric field (Fext) and ternary hydrogen bonding strategies. We observe significant changes in the excited state properties and charge transfer parame
In organic solar cells (OSCs), comprehending the charge transfer mechanism at D/A interfaces is crucial for photoinduced charge generation and enhancing power conversion efficiency (PCE). The charge transfer mechanism and photovoltaic performance of the parallel stacking interface configuration of the PTQ10 polymer donor and T2EH non-fullerene acceptor (NFA) are systematically studied at the micro
Nanowire (NW) optoelectronic and electrical devices offer unique advantages over bulk materials but are generally made by contacting entire NW arrays in parallel. In contrast, ultra-high-resolution displays and photodetectors require electrical connections to individual NWs inside an array. Here, we demonstrate a scheme for fabricating such single NW vertical devices by contacting individual NWs w
BACKGROUND: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensi
Despite the potential of smart home technologies (SHT) to support everyday activities, the implementation rate of such technology in the homes of older adults remains low. The overall aim of this study was to explore factors involved in the decision-making process in adopting SHT among current and future generations of older adults. We also aimed to identify and understand barriers and facilitator
State-of-the-art laser frequency stabilization is limited by miniscule length changes caused by thermal noise. In this work, a cavity-length-insensitive frequency stabilization scheme is implemented using strong dispersion in a 21 mm long cavity with a europium-ion-doped spacer of yttrium orthosilicate. A number of limiting factors for slow light laser stabilization are evaluated, including the in
Amyloids are elongated supramolecular protein self-assemblies. Their formation is a non-covalent assembly process and as such is fully reversible. Amyloid formation is associated with several neurodegenerative diseases, and the reversibility is key to maintaining the healthy state. Reversibility is also key to the performance of fibril-based biomaterials and functional amyloids. The reversibility
In this work, a specially designed experimental setup is employed to study the ignition and combustion of single aluminum droplets in hot steam-dominated flows. The transient burning behaviors of Al droplets of different sizes are characterized by simultaneously visualizing the flame incandescence and droplet shadowgraphs with two high-speed cameras at high magnification. The combustion process ca
In situ catalysis studies typically correlate catalytic function and majority surface structures, but neglect that difficult-to-detect minority structures might govern catalysis. Here we use an oscillating CO:O2 gas composition to drive structural oscillations on a catalytically active Pd(100) surface and collect X-ray photoelectron spectroscopy data at high measurement frequency to demonstrate th
INTRODUCTION: Breast cancer, a leading female cancer worldwide, can be influenced by mitochondrial dysfunction. Dysregulation of mitochondria by the nuclear genome may cause breast cancer initiation and progression. However, the comprehensive investigation of mitochondrial-related genes as prognostic marker for the overall survival of early-stage breast cancer patients is still limited.METHODS: To
We have investigated the adsorption of the amyloid-forming protein a-Synuclein (aSyn) onto small unilamellar vesicles composed of a mixture of zwitterionic POPC and anionic POPS lipids. aSyn monomers adsorb onto the anionic lipid vesicles where they adopt an a-helical secondary structure. The degree of adsorption depends on the fraction of anionic lipid in the mixed lipid membrane, but one needs t
Platinum-tin catalysts have been used industrially for decades, but their structural evolution under reaction conditions and the causes of their improved activity relative to platinum are still not well understood. In this study, we investigate Sn/Pt(111) and Sn/Pt(223) surface alloys during oxygen exposure and catalytic CO oxidation using grazing incidence X-ray absorption spectroscopy (GI-XAS).
