Filetype
Background: Galectin 3 and ST2 are mediators and biomarkers of myocardial fibrosis and remodeling that have recently entered the clinical practice guidelines as prognostic factors in heart failure patients. Elevated galectin 3 and ST2 levels in acute myocardial infarction patients have also been associated with increased incidence of adverse events during follow-up. Purpose: We aimed to assess the
Phosphorylation is a protein post-translational modification (PTM) that plays an important role in cell signaling, cell differentiation, and metabolism. The hyper phosphorylated forms of certain proteins have been appointed as biomarkers for neurodegenerative diseases, and phosphorylation-related mutations are important for detecting cancer pathways. Due to the low abundance of phosphorylated prot
Academic teacher development is an educational meeting place for academics already practising the art of teaching. Yet, it is in courses for this development that academics are supposed to be taught how to teach and how to improve their teaching skills. In my article I propose a new conceptual methodological framework for teaching teachers how to teach – Didactic Reasoning. Its foundation can be t
Background: Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Educa
Summary: Background: In 2014, the Swedish Association of Clinical Physiology recommended the use of a new reference material for exercise capacity in bicycle exercise stress testing, 'the Kalmar material'. Compared to the formerly used reference material, 'the Kristianstad material', an increase in the amount of patients being classified as having decreased exercise capacity was expected, but the
Do Chinese cities compete for investments with lax environmental law enforcement? The here presented study suggests that this is true for some municipalities but not all of them. Based on data for 126 key environmental protection cities and regional economic hubs between 2010 and 2012 we show that economic decentralization and political centralization both shape spatial patterns of compliance with
The gut microbiome of animals is emerging as an important factor influencing ecological and evolutionary processes. A major bottleneck in obtaining microbiome data from large numbers of samples is the time-consuming laboratory procedures required, specifically the isolation of DNA and generation of amplicon libraries. Recently, direct PCR kits have been developed that circumvent conventional DNA e
Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases. Given the role of complement in disease, there is a requirement for inhibitors to control the initiat
The number of triangulations of a planar n point set S is known to be cn, where the base c lies between 2.43 and 30. Similarly, the number of crossing-free spanning trees on S is known to be dn, where the base d lies between 6.75 and 141.07. The fastest known algorithm for counting triangulations of S runs in 2(1+o(1))nlog n time while that for counting crossing-free spanning trees runs in O (7.12
Background and Aims: There are limited data on the potential role of preoperative non-invasive markers, specifically the aspartate-to-alanine aminotransferase ratio and the aspartate aminotransferase-to-platelet ratio index, in predicting perioperative liver-related complications after hepatectomy for colorectal cancer metastases. Methods: Patients undergoing liver resection for colorectal cancer
Background & Aims Predniso(lo)ne, alone or in combination with azathioprine, is the standard-of-care (SOC) therapy for autoimmune hepatitis (AIH). However, the SOC therapy is poorly tolerated or does not control disease activity in up to 20% of patients. We assessed the efficacy of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy for patients with AIH. Methods We performed a r
A multiple-input-multiple-output (MIMO) dual-band antenna system consisting of two elements, each of which built up of circularly polarized slotted patch antenna for mm-wave band 5G wireless handheld and portable terminals is described. Space diversity is used to achieve a good independent channel fading in MIMO systems. In theoretical analysis of MIMO systems often assume that each antenna is iso
In situ Fourier transform infrared spectroscopy was used to study transient CO oxidation over a series of bimetallic Pd-Pt catalysts with different Pd:Pt molar ratios. The catalysts were found to contain both alloyed PdPt nanoparticles (particle sizes 25-35 nm) and monometallic Pd nanoparticles (sizes below 10 nm). For oxygen-free conditions, CO reduces the surface while simultaneously function as
Bone mineral density (BMD) is a complex trait with a strong genetic component and an important predictor of osteoporotic fracture risk. Here we report the use of a cross-species strategy to identify genes that regulate BMD, proceeding from quantitative trait mapping in mice to association mapping of the syntenic region in the human genome. We identified a quantitative trait locus (QTL) on the mous
This paper describes a numerical analysis of a heat transfer enhancement technique that introduces fractal-shaped design for impingement cooling. Based on the gas turbine combustion chamber cooling, a fractal-shaped nozzle is designed for the constant flow area in a single impingement cooling model. The incompressible Reynolds-averaged Navier-Stokes equations are applied to the system using CFD so
BACKGROUND: Pituitary tumours are common and easily treated by surgery or medical treatment in most cases. However, a small subset of pituitary tumours does not respond to standard medical treatment and presents with multiple local recurrences (aggressive pituitary tumours) and in rare occasion with metastases (pituitary carcinoma). The present European Society of Endocrinology (ESE) guideline aim
The taxonomic position and evolution of the five Scandinavian montane species previously referred to the informal group Depilata of Hieracium are discussed. There is very little modern information about these species and as they have not been listed under any of the currently accepted sections of the genus they are at risk of being completely forgotten. They have always been considered as intermed
Carbon fibre fabrics are electrically conductive and therefore possess the prerequisites for being inductively heated. In-situ heating by induction could significantly reduce processing time and energy consumption during consolidation of carbon fibre composites, but to control the induction heating process properly the electrical conductivity of the fabric must be known. The work presented in this
