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Collagen-induced arthritis (CIA) is a T cell-dependent autoimmune disease that serves as an animal model for human rheumatoid arthritis. CIA can be induced in H-2q mice by a single immunization with the cartilage-specific protein type II collagen (CII). This study has focused on CII immunity and tolerance with respect to the interactions between antigen, antigen-presenting cells and T cells. CIA-r
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When simulating homogenous charge compression ignition or HCCI using one-dimensional models it is important to have the right combustion parameters. When operating in HCCI the heat release parameters will have a high influence on the simulation result due to the rapid combustion rate, especially if the engine is turbocharged. In this paper an extensive testing data base is used for showing the com
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Popular Abstract in Swedish Information om smärta, klåda och temperaturförändringar förmedlas till centrala nervsystemet av tunna nervfibrer som leder nervimpulser relativt långsamt. Information om beröring av huden förmedlas istället av grova och snabbt ledande nervfibrer. Det är välkänt att olika känselkvaliteter kan interagera med varandra på olika nivåer i centrala nervsystemet. Vanlig berörinIt is known that stimulation of thin nerve afferents can inhibit itch and pain and that the nociceptive systems have a detailed topographical organisation, with subsystems exhibiting specific excitatory and inhibitory receptive fields. On this basis, a new technique was developed, termed Cutaneous Field Stimulation (CFS), that electrically stimulates thin nerve fibers innervating specific skin fie
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Popular Abstract in Swedish Strålningsterapi är en viktig metod för att behandla många cancertyper och man söker konstant efter olika sätt att förbättra användningen av joniserande strålning vid behandling. Radiobiologisk forskning för cancerterapi söker att förbättra vår förståelse för hur joniserande strålning verkar på olika livsformer. Idag finns det många sätt att utröna en behandlings inverkFor the development of a Single–Ion Hit Facility (SIHF) for living cells irradiation at the Lund Ion Beam Analysis facility (LIBAF), newly developed pre-cell detectors have been investigated. These detectors can determine the number of ions reaching the sample. Central to the thesis is their fabrication and characterization. Two different detectors ’ Design A and Design B’ were fabricated with thi
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Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasing population.
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Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. The CS and DS chains both consist of repeating disaccharides of the type (hexuronic aci
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In Australia a national public/private telematics framework has been established, which is administered by Transport Certification Australia (TCA). The first application was the Intelligent Access Program (IAP), which has enabled several road transport reforms by managing infrastructure risks associated with the operation of extra heavy vehicle configurations. The paper uses the IAP to demonstrate
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Popular Abstract in Swedish Inflammerat brosk i halsen. Rethosta eller andningsbesvär. Autoimmuna sjukdomar uppstår när immunförsvaret angriper och bryter ner den egna kroppens vävnader. Då kroppen infekteras av bakterier eller virus är immunförsvarets ökade aktivitet däremot en normal skyddsmekanism. Exempel på vanligt förekommande autoimmuna sjukdomar är diabetes, reumatoid artrit (RA) och multRelapsing polychondritis (RP) and rheumatoid arthritis (RA) are autoimmune diseases where an inappropriate immune response destroys cartilage. In RP, the ears, larynx, nose and joints are affected, while the most prominent sign of RA is arthritis. For ethical reasons many experiments can not be performed in man, and consequently animal models are needed. To investigate the complexity of the tissu
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