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Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (KATP) channels is a key event in this process. However, KATP channel closure alone is not sufficient to induce β-cell electrical activity; activation of a depolarizing membrane current is also required. Here we examine the role of the mechanosensor ion channel PIEZO1 in this process. Yod

This protocol describes the design and use of CRISPRi-mediated transcriptional silencing in human iPSCs, for loss-of-function studies in brain development research. The protocol avoids single cell selection, thereby eliminating side effects of clonal expansion and sites of viral integration. We also describe a neural progenitor differentiation protocol and discuss the challenges of target-specific

Serious outcomes as stroke, arrythmia and death are relatively frequent in patients presenting with dizziness. Within 30 days almost one in five patients re-attended the ED due to dizziness and 2,8% needed ED evaluation due to a fall. Decision support tools to help identify serious conditions and predict preventable falls in ED patients with dizziness are needed.

Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric renderi

Fe(II) N-heterocyclic carbene (NHC) complexes have emerged over the last decade as a promising class of light-harvesting complexes for a variety of photochemical applications relying on the presence of high-energy excited states of mainly charge-transfer character with excited state lifetimes of tens of picoseconds or longer. Recent spectroscopic investigations have significantly refined the under

Introduction: Anxiety disorders are common and debilitating in children and adolescents. Cognitive behavioral therapy (CBT), delivered both in-person and by the internet (ICBT), is efficacious, but access for young individuals is limited and it remains unclear how to structure the care pathway to maximize benefit.Methods: To inform a fully powered randomized controlled trial (RCT), a pilot RCT wil

This paper extends the application of quantile-based Bayesian inference to probability distributions defined in terms of quantiles of observable quantities. Quantile-parameterized distributions are characterized by high shape flexibility and parameter interpretability, making them useful for eliciting information about observables. To encode uncertainty in the quantiles elicited from experts, we p

Neurons with internal memory have been proposed for biological and bio-inspired neural networks, adding important functionality. We introduce an internal time-limited charge-based memory into a III-V nanowire (NW) based optoelectronic neural node circuit designed for handling optical signals in a neural network. The new circuit can receive inhibiting and exciting light signals, store them, perform

Engineering energy storage/extraction for geoenergy applications (e.g., geothermal energy extraction, CO2 and/or Hydrogen storage) requires a very good knowledge of subsurface heterogeneities. One of the principal factors that influences the response of the underground system is the continuously evolving pore networks of the targeted rocks. This work aims to understand the pore network of a natura

PURPOSE: Accurate whole-gland prostate segmentation is crucial for successful ultrasound-MRI fusion biopsy, focal cancer treatment, and radiation therapy techniques. Commercially available artificial intelligence (AI) models, using deep learning algorithms (DLAs) for prostate gland segmentation, are rapidly increasing in numbers. Typically, their performance in a true clinical context is scarcely

Climate-focused study abroad relying on high-emitting travel poses a dilemma between study abroad and emission reductions. This study employs the three spheres of transformation investigating this dilemma through coding syllabi (n=156,) surveying educators (n=9,) and interviewing (n=14) Climate Action Network for International Educators (CANIE) affiliates considering whether studying climate chang

Sverige är ett av få länder som har tagit fram en nationell handlingsplan för att omsätta FN:s vägledande principer för företag och mänskliga rättigheter på nationell nivå. FN:s vägledande principer skapar inga nya folkrättsliga förpliktelser, utan uppmuntrar endast stater att ta fram nationella handlingsplaner för att omsätta principerna på nationell nivå. Sveriges framtagande av planen kan såled

Kycklingkött är det kött med minst klimatpåverkan och fjäderfän, Gallus gallus, är den djurart som det föds upp flest av i världen. I Sverige ökar antalet fjäderfä samtidigt som den genomsnittliga besättningsstorleken ökar. Det är mer väsentligt än någonsin att hönsen som vi använder inom livsmedelsproduktionen mår bra och har en hög djurvälfärd. Synen är det sinnet som fåglarna använder mest och Factory produced chicken meat has the lowest climate impact and domesticated poultry, (Gallus gallus), is the world's most commonly bred animal. In Sweden the production of poultry is increasing, also the size of an average facility with chickens is increasing. Vision is their dominant sense organ and the vision is important for the animals to be able to explore their environment and search fo

Significant behavioral changes will need to be implemented to prevent the energy supply sector from tripling CO2 emissions by the midcentury. However, within the academic research, behavior changes remain primarily focused on the individual level, while the behavior of companies that are responsible for elevated greenhouse gas emissions falls behind. This master’s thesis analyses the core values

Syftet med denna studie är att nå nya kunskaper gällande värdering av ämnet musik, sett utifrån olika infallsvinklar. Studien syftar även till att belysa musikens påverkan på en skolmiljö och att understryka musikens värde i skolan. Studien utfördes vid en norsk grundskola i Spanien och bygger på kvalitativa intervjuer av fokusgrupper bestående av elever från olika årskurser, samt intervjuer med mThe purpose of this study is to obtain new knowledge on the perceived and given value of the subject music from different points of views. The study also intends to investigate the effect of music on a school environment and to examine its value in school. The study was made at a Norwegian school in Spain and it is based on qualitative interviews with focus groups including students from different

Segregation är ett föränderligt tillstånd som är komplext och påverkar såväl enskilda individer som samhället i stort. Exempelvis är stadsplaneringen en bakomliggande orsak som kan påverkar segregationen i en stad. För att det verkligen ska kunna ske en förbättring är det emellertid av stor vikt att åtgärder vidtas på olika plan och av olika aktörer. Det ursprungliga syftet bakom arbete är att utSegregation is a changing condition that is complex and affects individuals but also the society. Urban planning is for example an underlying cause that can affect segregation in a city. However, in order for an improvement, it is of great importance that measures are taken at different levels and by different actors. The primary purpose of the report was to study the impact that urban planning h

Exploring a prolonged life cycle of materials through an adaptive transformation Take, make and waste. Our society is trapped in a linear economic system where we extract raw materials, process them into products and as they have served their purpose they are reduced to waste. This unsustainable mentality seeps through to all things consumable, from fashion and cellphones to kitchen counters and

I samband med framarbetandet av 36 § avtalslagen uttrycktes olika uppfattningar vad beträffar hur domstolarnas avgöranden bäst bör utformas för att främja vägledning och förutsägbarhet i en annars obestämd generalklausul. Principiellt med möjlighet att stämpla villkor som oskäliga i sig framfördes i lagmotiven. Kausistiskt, baserat på omständigheterna i det enskilda fallet, menade flertalet remissIn connection with the preparation of section 36 of the Swedish Contracts Act, different views were expressed as to how the courts' decisions should best be formulated in order to promote guidance and hence predictability in an otherwise indefinite general clause. Principally designed with the possibility of stamping contract terms as unreasonable in itself, it was argued in the law motives. B