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We present a theory to compute the stable gap (interparticle) distance between particle chains collected in the pressure node of an acoustic standing wave. The primary and secondary acoustic radiation forces are the two competing forces that act on the particles during the particle chain formation. The stable equilibrium distance between two chains is reached when both forces are in balance. Most
DNA carries the genetic code of life, with different conformations associated with different biological functions. Predicting the conformation of DNA from its primary sequence, although desirable, is a challenging problem owing to the polymorphic nature of DNA. We have deployed a host of machine learning algorithms, including the popular state-of-the-art LightGBM (a gradient boosting model), for b
Transplantation in Parkinson's disease using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons is a promising future treatment option. However, many of the mechanisms that govern their differentiation, maturation, and integration into the host circuitry remain elusive. Here, we engrafted hESCs differentiated toward a ventral midbrain DA phenotype into the midbrain of a preclinical
This contribution analyses the evolution of public support for the single European currency, the euro, from 1990 to 2014 for a 12-country sample of the euro area (EA-12), focusing on the most recent period of the financial and sovereign debt crisis, starting in 2008. We find that citizens’ support for the euro on average was marginally reduced during the first six years of the crisis, and that sup
Commentary and analysis of the proposal of the Swedish Ministry of Justice (Ds 2021:30) concerning implementation of Article 17 Directive 2019/790 on copyright and related rights in the Digital Single Market (DSM Directive). Part 2 of 2.
Swetra is primarily a research project, but its computer programs and reports may result in commercial products. The research group at Lund consists of a few persons only, which has advantages eind disadvantages. The main languages studied are Russian, English and Swedish. The grammatical model is Referent Grammar (RG) and the project is a spin-off of the development of that grammar. Referent Gram
Despite decades of research on the pathophysiology of depression, the development of new therapeutic interventions has been slow, and no biomarkers of treatment response have been clinically implemented. Several lines of evidence suggest that the clinical and biological heterogeneity among patients with major depressive disorder (MDD) has hampered progress in this field. MDD with low-grade inflamm
Objectives: . SLE is an autoimmune disease with increased cardiovascular morbidity and platelet activation. In the general population, increased platelet size predicts platelet reactivity and cardiovascular disease. The aim of this study was to investigate whether platelet size related to platelet activation and cardiovascular disease in SLE.Methods: . Fresh blood samples from SLE patients ( n = 1
Purpose -The purpose of this paper is to investigate the added value of using temperature-dependent electric and magnetic properties in high-Temperature electromagnetic simulations. Design/methodology/approach - In this work, the electromagnetic properties of Domex 420, SSAB, have been characterized as a function of the temperature, from room temperature to 900°C. The measurement of the electric a
This chapter provides an overview of the main concepts in mechanobiology and touches upon the experimental models that are most frequently used to study mechanobiology on a cell and tissue level. It focuses on the use of computational techniques and algorithms to simulate mechanobiological processes, and their prospective potential in clinical applications. It covers how computational algorithms h
The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.With the intention to The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons. With the intention to
BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) dat
Traumatic brain injury (TBI) commonly results in injury to the components of the white matter tracts, causing post-injury cognitive deficits. The myelin-producing oligodendrocytes (OLs) are vulnerable to TBI, although may potentially be replaced by proliferating oligodendrocyte progenitor cells (OPCs). The cytokine interleukin-1β (IL-1β) is a key mediator of the complex inflammatory response, and
The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient formi
