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OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study

Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question:

High prevalence of interstitial lung abnormalities in middle-aged never-smokers

Background Interstitial lung abnormalities (ILA) are incidental findings on chest computed tomography (CT). These patterns can present at an early stage of fibrotic lung disease. Our aim was to estimate the prevalence of ILA in the Swedish population, in particular in never-smokers, and find out its association with demographics, comorbidities and symptoms. Methods Participants were recruited to t

Neighborhood green spaces and use of social services in an older urban population

With an aging population, an increased burden is put on national and regional healthcare and social systems. In Sweden, municipalities are required to provide inhabitants with the social services needed to enable them to live an independent life in their own home for as long as possible. Urban green spaces (UGS) may increase physical activity and social interaction, as well as improve wellbeing an

Mellan juridisk fixering och flexibilitet i den europeiska AI-förordningen

Det är mycket rörelse på AI-fronten nu – både rättsligt, tekniskt och politiskt. Stefan Larsson, jurist och docent i teknik och social förändring vid Lunds universitet, placerar in EU-lagstiftarens AI-förordning i en både global och svensk kontext. Han beskriver processen bakom lagstiftningen, de etiska och principiella grunderna, och hur EU-lagstiftaren hanterar AI-innovationernas explosionsartad

Nordic influences on Swedish construction law - an example on the value of comparing standard contracts

This article investigates the dependence on standard contracts in Swedish construction law, particularly AB 04 and ABT 06, due to a lack of specialized laws. Comparing them to similar contracts from other Nordic countries demonstrates the value of cross-border legal understanding. A 2018 Swedish Supreme Court judgment highlights this technique, implying that comparative analysis might improve lega

Evaluation of superficial xenograft volume estimation by ultrasound and caliper against MRI in a longitudinal pre-clinical radiotherapeutic setting

BackgroundAccurate tumor volume estimation is important for evaluating the response to radionuclide therapy and external beam radiotherapy as well as to other pharmaceuticals. A common method for monitoring the growth of subcutaneous tumors in pre-clinical models and assessing the treatment response is to measure the tumor length and width by external calipers to estimate its volume. This procedur

Digital advocacy and algorithms : Challenges and opportunities for civil society

This chapter is about digital advocacy and civil society in the era of Artificial Intelligence (AI). Social media has often been discussed as a game-changer when it comes to advocacy. The technical structures of social media are continuously changing and, therefore, so are the conditions for digital advocacy. Extensive research has focused on different digital advocacy strategies. However, there h

Quinoa Starch Granules as Emulsion Stabilizers

Quinoa (Chenopodium quinoa Willd.) has gained recent popularity mainly due to its attractive nutritional profile and its ability to grow under extreme conditions such as salinity, acidity, drought, flooding, and frost as well as the functionality of its component. Starch is the main component of quinoa grain which constitutes up to 60% of the dry grain and plays a crucial role in the functional pr

Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer’s disease-transgenic mice

Alzheimer’s disease (AD) is the most common neurodegenerative disease. Most cases of AD are considered idiopathic and likely due to a combination of genetic, environmental, and lifestyle-related risk factors. Despite occurring decades before the typical age of an AD diagnosis, early-life stress (ELS) has been suggested to have long-lasting effects that may contribute to AD risk and pathogenesis. S

AI och risker för diskriminering i arbetslivet

Många arbetsgivare känner inte till att de redan idag använder sig av artificiell intelligens, AI, eller annat automatiserat beslutsfattande. Det visar den rapport om AI och risker för diskriminering i arbetslivet som Diskrimineringsombudsmannen, DO, publicerar idag. Att arbetsgivare har denna kunskap är avgörande för att arbeta förebyggande för att motverka diskriminering vid tillämpning av tekni

Inhibitory control as possible risk and/or resilience factor for the development of trauma related symptoms–a study of the Utøya terror attack survivors

PTSD symptomatology is known to be associated with executive dysfunction. Inhibitory control is a core component of executive functioning, and inhibitory skills are essential both for adequate functioning in everyday life and important in situations following trauma. The aim of the present study was to examine the relationship between trauma exposure, inhibitory control and PTSD symptomatology in

Expanding the lens on child-centered relatedness and parents’ care work in education: reflections from fieldwork in Singapore

This paper aims to initiate a discussion on the meanings and manifestations of child-centered relatedness, with a particular focus on parents’ educational care work and how parents navigate sentiments of uncertainty and risk in relation to their children’s future. By drawing on examples from ethnographic fieldwork in East Asia, I hope to contribute to expanding the lens on the moral and emotional

Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction

Background and Aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods: The relationship betwee

Polarisation Development at the European Spallation Source

To meet the ever-increasing user demand, eleven of the fifteen European Spallation Source (ESS) instruments under construction aim to offer polarised neutrons for user experiments. They include an imaging instrument, a SANS instruments, two reflectometers, three diffractometers, and four spectrometers. In conjunction with in-kind contributions and instrumentation grants, the ESS Polarisation Proje

Neurocognitive Functioning in Patients with Painful Temporomandibular Disorders

Aim: To investigate psychosocial factors in painful TMD (pTMD) which could have consequences for mastering chronic pain. Methods: Our study included 22 patients (20 women, 2 men) with pTMD, refractory to conservative treatment, and 19 healthy controls. The control group was matched for gender, age, and educational level, and IQ tested on the Wechsler Abbreviated Scale of Intelligence. Neurocogniti

Fresh and Aged Organic Aerosol Emissions from Renewable Diesel-Like Fuels HVO and RME in a Heavy-Duty Compression Ignition Engine

A modern diesel engine is a reliable and efficient mean of producing power. A way to reduce harmful exhaust and greenhouse gas (GHG) emissions and secure the sources of energy is to develop technology for an efficient diesel engine operation independent of fossil fuels. Renewable diesel fuels are compatible with diesel engines without any major modifications. Rapeseed oil methyl esters (RME) and o

Fluorescently Guided Optical Photothermal Infrared Microspectroscopy for Protein-Specific Bioimaging at Subcellular Level

Infrared spectroscopic imaging is widely used for the visualization of biomolecule structures, and techniques such as optical photothermal infrared (OPTIR) microspectroscopy can achieve <500 nm spatial resolution. However, these approaches lack specificity for particular cell types and cell components and thus cannot be used as a stand-alone technique to assess their properties. Here, we have deve

Field Delineation Using Medical Subject Headings (MeSH) : An alternative way to aggregate data in the web of science

Field delineation is important in bibliometrics. Particularly when measuring scientific performance, the demarcation of the area, to which a science actor belongs, is of the greatest importance. This paper present a method based on searches on Boolean combinations of medical subject headings (MeSH-terms) in a combined Web of Science (WoS) - Medline database. The construction of the MeSH area defin