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PURPOSE: We know that pain has far-reaching detrimental effects across various life-domains and also affects health related quality of life after solid organ transplantation. However, the extent to which heart recipients experience chronic bodily pain in the years after heart transplantation is a neglected field. Pain is reported to be a major problem after other types of solid organ transplantati
Laser Shock Peening (LSP) and conventional Shot Peening (SP) are processes that aim to improve the surface properties of a workpiece by inducing compressive residual stresses. The peening processes also cause martensitic phase transformation in austenitic steels. Interestingly, experimental studies report significant differences in martensite content depending on the used peening process. This stuLaser Shock Peening (LSP) and conventional Shot Peening (SP) are processes that aim to improve the surface properties of a workpiece by inducing compressive residual stresses. The peening processes also cause martensitic phase transformation in austenitic steels. Interestingly, experimental studies report significant differences in martensite content depending on the used peening process. This stu
Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better
Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors
Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has been found to result in inefficient erythropoiesis because of deregulated coordination of cell cycle exit and mitochondrial biogenesis. However, the pathophysiology remains to be fully described, and further chara
AIMS: We aimed to search for associations between cognitive test results with mortality and rehospitalization in a Swedish prospective heart failure (HF) patient cohort.METHODS AND RESULTS: Two hundred and eighty-one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making T
Osteoarthritis (OA) constitutes a major and increasing burden on patients, health care systems and the broader society. It is estimated that around a quarter of the adult population is affected by OA in the knee and hip and that the prevalence of OA will increase over the coming decades largely due to aging and adverse life-style factors. Prevention and effective care are critical to manage the ch
Global handel är ett försummat område i debatten om Antropocen, men spelar en implicit roll i många av dess definitioner. Handelns roll i att förskjuta miljöbelastning över Jorden skiljer sig väsentligt mellan det 'Columbianska utbytet' (1492-1800), den Industriella Revolutionen (~1800-1950), och den Stora Accelerationen (efter 1950). Vår systematiska översikt över forskningsläget visar emellertidGlobal trade is a neglected topic in debates on the Anthropocene, but plays an implicit role in several suggested definitions of it. Trade’s role in shifting environmental burdens around the globe differed substantially between the Columbian Exchange (1492−1800), the Industrial Revolution (~1800−1950) and the Great Acceleration (post-1950). However, this systematic state-of-the-art review shows th
Desludging is considered a key step in urban sanitation improvement. Nevertheless, in most urban unplanned settlements, desludging is performed in an unhygienic manner, risking public health. This study used a combination of qualitative and quantitative methods to analyse the underlying factors for unhygienic desludging in three urban unplanned settlements of Dar es Salaam, Tanzania. Factors for u
Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms
Partially Premixed Combustion (PPC) has shown its potential by combining high combustion controllability with emission characteristics that are close to those of an HCCI engine. In order to get PPC the ignition delay needs to be long enough for the fuel and air to mix prior to combustion. This can be achieved by injecting the fuel sufficiently early while running with high EGR.In order to find out
Net primary production (NPP) is modeled for a coniferous forest in southern Sweden for 2001. The model is based on the light-use efficiency concept where NPP is calculated as a product of absorbed photosynthetically active radiation (APAR) and a light-use efficiency factor (ε). APAR is estimated from the fraction of APAR (FAPAR) multiplied with the daily total amount of incoming PAR. FAPAR is obta
ObjectivesProstate volume (PV) in combination with prostate specific antigen (PSA) yields PSA density which is an increasingly important biomarker. Calculating PV from MRI is a time-consuming, radiologist-dependent task. The aim of this study was to assess whether a deep learning algorithm can replace PI-RADS 2.1 based ellipsoid formula (EF) for calculating PV.MethodsEight different measures of PV
I avhandlingen undersöks vilka störningar i entreprenadavtal som kan ge entreprenören rätt till tidsförlängning.Med störning avses i avhandlingen en omständighet som avviker från vad entreprenören förutsatt (antagit) senast vid avgivandet av sitt löfte (anbud) att ingå avtalet som gör att entreprenörens arbeten inte kan utföras som planerat och som orsakar tillkommande kostnader, en försening elle
After World War I, millions of men went back from the war front promised of land, work and social justice, but their expectations were unfulfilled by the governments of European countries. In this context, the political landscape was enriched of new ideas, and several new parties, movements and associations born across Europe. In Italy, ANMIG (Disabled Ex-Servicemen National Association) was found
This book considers how the concept of violence has been interpreted, used, defined, and explored by social researchers and thinkers. It does not provide a final answer to the question of what violence is or how it should be explained (or prevented), and instead offers a variety of useful ways of thinking about and theorising the phenomenon, mainly from a sociological standpoint. It outlines four This book considers how the concept of violence has been interpreted, used, defined, and explored by social researchers and thinkers. It does not provide a final answer to the question of what violence is or how it should be explained (or prevented), and instead offers a variety of useful ways of thinking about and theorising the phenomenon, mainly from a sociological standpoint. It outlines four
Aim of the studyRates of bystander CPR are increasing, yet mortality after out-of-hospital cardiac arrest (OHCA) remains high. The aim of this survey was to explore public knowledge and attitudes to CPR. Our hypotheses were that recent CPR training (< 5 years) would be associated with a high-quality response in a case vignette of OHCA with agonal breathing, and associated with an interest to becom
