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Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness

OBJECTIVE: While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortalit

Global trade in the Anthropocene : A review of trends and direction of environmental factor flows during the Great Acceleration

Global handel är ett försummat område i debatten om Antropocen, men spelar en implicit roll i många av dess definitioner. Handelns roll i att förskjuta miljöbelastning över Jorden skiljer sig väsentligt mellan det 'Columbianska utbytet' (1492-1800), den Industriella Revolutionen (~1800-1950), och den Stora Accelerationen (efter 1950). Vår systematiska översikt över forskningsläget visar emellertidGlobal trade is a neglected topic in debates on the Anthropocene, but plays an implicit role in several suggested definitions of it. Trade’s role in shifting environmental burdens around the globe differed substantially between the Columbian Exchange (1492−1800), the Industrial Revolution (~1800−1950) and the Great Acceleration (post-1950). However, this systematic state-of-the-art review shows th

Drivers of unhygienic desludging practices in unplanned settlements of dar es Salaam, Tanzania

Desludging is considered a key step in urban sanitation improvement. Nevertheless, in most urban unplanned settlements, desludging is performed in an unhygienic manner, risking public health. This study used a combination of qualitative and quantitative methods to analyse the underlying factors for unhygienic desludging in three urban unplanned settlements of Dar es Salaam, Tanzania. Factors for u

Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults

Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms

Investigation of the Combustion Characteristics with Focus on Partially Premixed Combustion in a Heavy Duty Engine

Partially Premixed Combustion (PPC) has shown its potential by combining high combustion controllability with emission characteristics that are close to those of an HCCI engine. In order to get PPC the ignition delay needs to be long enough for the fuel and air to mix prior to combustion. This can be achieved by injecting the fuel sufficiently early while running with high EGR.In order to find out

Mapping NPP for a coniferous forest in southern sweden using data from Terra/MODIS

Net primary production (NPP) is modeled for a coniferous forest in southern Sweden for 2001. The model is based on the light-use efficiency concept where NPP is calculated as a product of absorbed photosynthetically active radiation (APAR) and a light-use efficiency factor (ε). APAR is estimated from the fraction of APAR (FAPAR) multiplied with the daily total amount of incoming PAR. FAPAR is obta

Estimering av illikviditetsrabatter

Sammanfattning Examensarbetets titel: Estimering av illikviditetsrabatter Seminariedatum: 2011-06-03 Ämne/kurs: FEKK01, Examensarbete kandidatnivå, 15 Hp Författare: Robert Johansson och Harald Karlsson Handledare: Tore Eriksson Nyckelord: Alternativa Aktiemarknaden, Aktietorget, OMX Small Cap, Illikviditetsrabatter, likviditet, illikviditet Syfte: Syftet är att undersöka i vilken mån illikviditet

On Randomness, Uncertainty, and Rare Events in Political Science

This essay examines the implicit relationship between political science and rare events, or so called Black Swans. The purpose is to analyze Black Swan weakness by evaluating the nature of political analysis and political theories. The key to this assessment is the analysis of the predictive powers of political analysis and theories. This essay claims, on the basis of Karl Poppers historicism crit

Zinc speciation in fine and coarse fly ash particles collected in-flight at a waste incinerator

afe and optimized utilization of waste-to-energy (WtE) fly ash (FA) requires a detailed understanding of the physicochemical properties of its metal constituents. This study provides a comprehensive analysis of the chemical form of Zn in fine (<1 μm) and coarse (>1 μm) FA particles, hypothesized to originate from different formation mechanisms. Size-selective aerosol sampling was performed during

Clinical aspects of impulsive-compulsive behaviors under dopaminergic treatment-A scoping review

ObjectiveDopaminergic medications are commonly prescribed for Parkinson's disease (PD), restless legs syndrome, pituitary and psychotic disorders. Accumulating evidence indicates that dopaminergic treatment triggers impulsive-compulsive behaviors (ICBs), yet systematic synthesis of clinical evidence remains limited.MethodThis scoping review summarizes original research directly clinically relevant

Multispectral coded light for high-speed temperature imaging of aluminum combustion

Aluminum is a promising carbon-free energy carrier, but advancing its use requires detailed understanding of its combustion behavior at the single-particle level. Measuring the transient surface temperatures of burning aluminum droplets is particularly challenging due to their small size, extreme temperatures, and fast dynamics. In this work, we demonstrate a multispectral pyrometry approach based

Ultrafast Spectroscopy Reveals Significant Differences in LH2 Exciton Mobility at Cryogenic and Ambient Temperatures

Spectroscopic studies of energy transport through the photosynthetic apparatus have been crucial to expanding our understanding of biological energy conversion. Correlating spectroscopic information to the electronic structure and function in these complex systems remains highly challenging, however. While cryogenic experimental conditions help in improving the effective spectral resolution and sa

Better reporting is better science : Community-defined minimal reporting requirements for light microscopy

Incomplete reporting of microscopy methods undermines transparency, reproducibility, and data reuse. Despite recent initiatives, comprehensive, broadly endorsed, and accessible reporting guidelines are still lacking. Here, we present a bare minimal microscopy reporting requirements checklist that integrates human- and machine-readable input to provide clear, actionable guidance for researchers, re

The representation of climate impacts in the FRIDAv2.1 Integrated Assessment Model

Feedbacks from the climate to other components of the coupled human-Earth system are expected to strongly influence the co-evolution of human society and its environment. Representing these feedback loops between climate and society, via the Earth system's response to human activities and the subsequent effect back onto social systems, is essential in order to fully explore the dynamics of the cou

Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes

Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i

Free Sugar Intake and Dementia Risk : A Swedish Cohort Study on Dietary Sources and Dementia Subtypes

Background: Dementia is a growing public health concern, and although diet is a modifiable potential risk factor, the role of free sugar intake remains unclear. Excess sugar has been linked to metabolic and cardiovascular dysfunction, both associated with cognitive decline, but evidence regarding specific sugar sources is limited. Objectives: This study aimed to investigate the associations betwee

Transboundary aquifer cooperation : supranational coordination in managing the North-Western Sahara Aquifer System

The North-Western Sahara Aquifer System (NWSAS) shared by Libya, Tunisia, and Algeria is one of North Africa’s biggest nonrenewable groundwater storage systems. The management of its resources in a sustainable way will be central to regional stability, food security, and climate resilience. This book chapter discusses how transboundary cooperation along the NWSAS has evolved through facilitation b

(Dis)Connected : Digital Theology in and between Contexts

This pioneering volume explores complex local, global and digital contexts from the perspectives of Digital Theology.The use of and access to digital technology is highly contextual. It differs between regions, generations, classes, religious denominations, and gender. Which problems theologians claim to be important and which developments they ignore is contingent on their cultural, social, econo