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Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee,
The issue of factors predisposing for inhibitor development in haemophilia patients is still largely unresolved. In an attempt to address this problem, we initiated a registry in 1996 of siblings with haemophilia and with or without a history of inhibitors. Four hundred and sixty families have accrued, of whom 388 suffer from haemophilia A and 72 haemophilia B. Twenty-five of the brother pairs are
Redox chemistry is central to the primary functions of chloroplasts and mitochondria, that is, to energy conversion in photosynthesis and respiration. However, these bioenergetic organelles always contain very small, specialized genetic systems, relics of their bacterial origin. At huge cost, organellar genomes contain, typically, a mere 0.1% of the genetic information in a eukaryotic cell. There
The “acidic mantle” of the skin surface has been related to several essential functions of the skin, although the origin of the acidity is still obscure. In this paper, we investigate how different transport processes can influence the local proton concentration inside a membrane consisting of oriented lipid bilayers. This system is chosen as a simple model of the extracellular lipids in the upper
The purpose of this study was to identify new prognostic biomarkers with clinical impact in malignant peripheral nerve sheath tumor (MPNST), a highly aggressive malignancy for which no consensus therapy exists besides surgery. We have used tissue microarrays (TMAs) to assess in situ expression of 14 cell-cycle-regulating proteins in 64 well-characterized MPNST patients: 36 sporadic and 28 with neu
Screening for cervical cancer precursors by cytology has been very successful in countries where adequate resources exist to ensure high quality and good coverage of the population at risk. Mortality reductions in excess of 50% have been achieved in many developed countries; however the procedure is generally inefficient and unworkable in many parts of the world where the appropriate infrastructur
Currently in Europe as well as in the United States, an increasing proportion of very old people remain living in their homes despite declines in physical and mental health. Together with the fact that the population of very old people is rapidly increasing (Mathers, Sadana, Salamon, Murray, Lopez, 2001; United Nations Development Programme, 2001), this poses new challenges to societal planning an
Objectives: Underweight, overweight, and obese women aged 18–34 years were compared with normal weight women of the corresponding age according to socioeconomic, psychosocial, health behaviour, self reported global and psychological health, and locus of control characteristics. Methods: The 2000 public health survey in Scania is a cross-sectional study. A total 13 715 persons aged 18–80 years, of
A global existence result for solutions u(t) of the differential equation x" + f(t, x) = p(t), t >= t(0) >= 1, that can be written as u(t) = P(t) + o(l) for all large t, where P"(t) = p(t), is established by means of the Schauder-Tikhonov theorem. It generalizes the recent work of Lipovan [On the asymptotic behaviour of the solutions to a class of second order nonlinear differential equations, Gla
Fifty years after its prediction, the highest-lying [ 2 0 2] 3) 2 orbit among the six Nilsson single-particle orbits originating from the sd shell in prolately deformed nuclei and the rotational band on this orbit were identified. The band members were observed in Al-25 at excitation energies of 6-7.5MeV in a high-resolution Mg-25(He-3,t) charge-exchange reaction at 0 degrees having a strong selec
For a detailed understanding of the function of photosystem II (PSII), a molecular structure is needed, The crystal structure has not yet been determined, but the PSII reaction center proteins D1 and D2 show homology with the L and M subunits of the photosynthetic reaction center from purple bacteria, We have modeled important parts of the D1 and D2 proteins on the basis of the crystallographic st
A model for a special configuration in triaxial odd-odd nuclei is constructed which exhibits degenerate chiral bands with a sizable rotation, a manifestation of dynamical spontaneous symmetry breaking. A quantum number obtained from the invariance of the model Hamiltonian, which characterizes observable states, is given and selection rules for electromagnetic transition probabilities in chiral ban
A 120 kHz echo sounder, with two split-beam transducers, was used horizontally to monitor the behaviour of 0+ roach Rutilus rutilis, from June to August, in field enclosures. 0+ roach outside the vegetated area of the enclosures were registered both as schools and as single swimming fish. Combining echo counting and tracking with direct observation of echograms, an estimate of relative abundance o
The organic fraction of atmospheric aerosols contains a multitude of compounds and usually only a small fraction can be identified and quantified. However, a limited number of representative organic compounds can be used to describe the water-soluble organic fraction. In this work, initiated within the EU 5FP project SMOCC, four mixtures containing various amounts of inorganic salts (ammonium sulf
In the present paper, an optimization of the draw-in of an automotive sheet metal part has been carried out using Response Surface Methodology (RSM) and Space Mapping technique. The optimization adjusts the drawbead restraining force in the model such that the draw-in in the FE model corresponds to the draw-in in the physical process. The conclusion of this study is that Space Mapping is a very ef
