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Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously evolved, giving rise to multiple variants that have significantly altered the trajectory of the COVID-19 pandemic. These variants have resulted in multiple waves of the pandemic, exhibiting characteristic mutations in the spike (S) protein that may have affected receptor interaction, tis

As rapid urbanization intensified pressure on coastal ecosystems, balancing economic development with ecological preservation remained a critical challenge. This study developed a multi-criteria framework for integrated marine spatial planning and applied it to Shenzhen, China—a rapidly expanding coastal metropolis overseeing 1145 km2 of marine territory with a 260.5 km coastline, 61.47% of which

Background: Surgical site infection (SSI) following orthopedic surgery is a complication associated with morbidity and economic burden. Transmission of airborne bacteria that settle into surgical wounds constitutes a risk factor for SSIs. However, monitoring microbial contamination inside operating rooms with conventional methods is resource and time-consuming. Aim: This study aimed to assess corr

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of higher − compared with standard − initial doses of surfactant in high-risk preterm infants and preterm infants with respiratory distress syndrome.

Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before

As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinica

Work in developmental pragmatics has shown that even though infants display refined mindreading abilities, older children struggle to understand language phenomena that rely on mindreading. This apparent mismatch might be partially explained by considering children's growing sensitivity to social categories such as their interlocutor's age. Based on recent work in philosophy of mind, we investigat

Principal component analysis (PCA) and k-nearest neighbor (kNN) can be applied to extract and compare activity distributions from electrocorticogram (ECoG) signals across recorded neural activity. Here, we present a protocol for recording ECoG activity from the neocortex of rats and applying PCA and kNN on the recorded data. This protocol allows for comparison between different types of cortical a

To address the need for sustainable wastewater treatment, we developed sp2‑carbon-rich, hierarchically porous electrodes by upcycling sewage sludge ash (SSA) and biochar (CB) using a hybrid 3D printing and microwave plasma-enhanced chemical vapor deposition (MPECVD) approach. The CB-containing electrode exhibited a 260-fold increase in BET surface area (0.15 to 40.6 m2 g−1), but the lowest electro

Lung imaging in mouse disease models is crucial for the assessment of the severity of airway disease but remains challenging due to the small size and the high porosity of the organ. Synchrotron inline free-propagation phase-contrast computed tomography (CT) with its intrinsic high soft-tissue contrast provides the necessary sensitivity and spatial resolution to analyse the mouse lung structure in

In contemporary enterprises, customer satisfaction analysis has become a critical area of concentration. Being able to understand and predict customer satisfaction is becoming more and more important as companies try to develop and launch new products. Leveraging customer data intelligently and employing robust data analytics techniques are essential for meeting this imperative. With this objectiv

Since the introduction of the RUT tax deduction in 2007, the market for private domestic care services has grown rapidly in Sweden. Today, deductions can be made for cleaning and gardening, as well as for care services such as going for walks, providing companionship, assisting with dressing, and helping with personal hygiene. One main group that make use of the tax deduction are elderly over the

Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d

Several studies have reported that heterosexual women's preferences for male faces vary with hormonal fluctuations over the menstrual cycle and that women tend to prefer more masculine faces during ovulation or when not using hormonal contraceptives. While this has been tested using observational data, we provide the first double-blind randomized controlled study testing if oral contraceptives red

Identifying patients at high risk of bone fracture is an important task. The clinical risk assessment, based on measurements of bone mass, correlates with strength but not toughness and is insufficient for reliable identification of high-risk patients. Starting from non-linear fracture mechanics, we hypothesise that reduced bone tissue fracture toughness and characteristic length, possibly in comb

Background: In this study, we further developed an artificial intelligence (AI)-based method for the detection and quantification of tumours in the prostate, lymph nodes and bone in prostate-specific membrane antigen (PSMA)-targeting positron emission tomography with computed tomography (PET–CT) images. Methods: A total of 1064 [18F]PSMA-1007 PET–CT scans were used (approximately twice as many com

Background: Child and Adolescent Mental Health Services (CAMHS) currently seeks to implement service models that are better suited for young service users with complex mental health needs. This study explored what adolescents view as the key components of a well-functioning contact with CAMHS. Methods: This study was conducted as part of the ongoing implementation of Flexible Assertive Community T

Measurements of the stable carbon isotope ratio in methane (δ13C-CH4) are used in determining the source of CH4 emissions on local, regional, and global scales. To achieve the required level of data comparability for atmospheric monitoring networks, accurate gas reference materials of δ13C-CH4 in air are required with high levels of reproducibility. We describe a method to determine the δ13C-CH4 o

BACKGROUND: Balloon-guide catheters (BGC) have been associated with improved procedural and functional outcomes following endovascular thrombectomy (EVT) in multiple observational studies. Recently the PROTECT-MT trial challenged this benefit, showing worse functional outcomes when using BGCs. This study aims to assess the association between BGC-use and procedural and functional outcomes in a lar