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System Dynamics (SD) is a method that allows for integrated modelling of technical as well as managerial aspects responsible for the dynamic complexity of systems. Therefore, simulation of SD models can also be a tool for problem analysis within software organisations. In this paper, experience with SD modelling of software processes and projects within Siemens is reported. Special focus is put on

Follow-up of endovascular aneurysm repair (EVAR) with life-long computed tomography angiography (CTA) surveillance exposes patients with impaired renal function to repeated risks of contrast medium-induced nephropathy (CIN).

Abstract Aim: To investigate trends in mortality and morbidity in very preterm infants. Methods: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. Results: Data from 1614 liveborn infants were included. There was an inc

Background: On-demand therapy with esomeprazole is effective for long-term treatment of non-erosive gastro-oesophageal reflux disease, but it has not been evaluated in erosive gastro-oesophageal reflux disease. Aims: To compare endoscopic and symptomatic remission over a 6-month period when patients with healed erosive gastro-oesophageal reflux disease are treated with esomeprazole 20 mg, either o

This is the first part of a series of papers devoted to direct and inverse scattering of transient waves in lossy inhomogeneous media. The medium is assumed to be stratified, i.e., it varies only with depth. The wave propagation is modeled in an electromagnetic case with spatially varying permittivity and conductivity. The objective in this first paper is to analyze properties of the scattering op

Nucleoside analogues (NA) are prodrugs that are phosphorylated by deoxyribonucleoside kinases (dNKs) as the first step towards a compound toxic to the cell. During the last 20 years, research around dNKs has gone into new organisms other than mammals and viruses. Newly discovered dNKs have been tested as enzymes for suicide gene therapy. The tomato thymidine kinase 1 (ToTK1) is a dNK that has been

BACKGROUND: Liver resection is a possibly curative treatment for colorectal cancer (CRC) liver metastases. Preoperative chemotherapy may make initially irresectable tumors resectable. The aim of this study was to compare perioperative course and short-term mortality after liver resection for CRC metastases between patients who were and were not treated with preoperative chemotherapy. METHODS: Pati

Abstract Background and Aim of the Study: The aim of this study was to evaluate the impact of pulmonary hypertension (PH) on early and late outcomes following surgery in patients with degenerative mitral regurgitation. Methods: The study included 270 patients who had undergone isolated mitral valve surgery (MVS) for leaflet prolapse during 1998 to 2010. Pulmonary artery systolic pressure (PASP) wa

Wilms' tumor (WT), the most common kidney tumor among children, is characterized by a triphasic morphology consisting of blastemal, epithelial, and stromal components. Adult WT is a rare malignancy displaying similar histological features. We here present the first published high-resolution genomic analysis of a mixed-type adult WT. This revealed a more pronounced genetic complexity than usually o

Aims: This study summarises the health-related quality of life (HRQOL) scores and absenteeism caused by sinus problems in patients awaiting surgery with the diagnoses recurrent acute rhinosinusitis (RARS), chronic rhinosinusitis with nasal polyps (CRS+NP) or CRS without nasal polyps (CRS-NP), in a prospective multi-centre study. Methodology: Two hundred and seven patients with RARS, CRS+NP or CRS-

A diagnosis of malignant hyperthermia (MH) can be determined by performing an in vitro (muscle) contracture test (IVCT) or by identifying a known MH causative mutation in the ryanodine receptor 1 gene (RYR1). Genetic diagnosis has an advantage over IVCT because it is less invasive. Direct sequencing of the very large RYR1 coding region (15.117 bases) is a laborious and expensive task. In this stud

Since the publication of the European League Against Rheumatism recommendations for the pharmacological treatment of psoriatic arthritis (PsA) in 2012, new evidence and new therapeutic agents have emerged. The objective was to update these recommendations.

Screening for abdominal aortic aneurysm (AAA) among 65 year old men has been proven cost-effective, but nowadays is conducted partly under new conditions. The prevalence of AAA has decreased, and endovascular aneurysm repair (EVAR) has become the predominant surgical method for AAA repair in many centers. At the Malmö Vascular Center pharmacological secondary prevention with statins, antiplatelet

This article presents a reading of two Greek Marian hymns written in the centuries after the Ephesus Council: the Annunciation Hymn by Romanos the Melodist, which is the earliest extant Annunciation hymn we have, and the well-known Akathistos Hymn. Many scholars believe the latter to be a fifth century composition, and not – as have been claimed by such important scholars as Constantinos A. Trypan

Society is becoming increasingly dynamic and complex, and therefore more vulnerable. It is thus important that society is resilient in order to be able to protect citizens and critical functions in the wake of disasters. It has been suggested that disaster risk reduction (DRR) is key in establishing resilience, and that adequate capacity in DRR is vital to reduce the effects of disasters. DRR and