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Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bacter
Objective: The addition of adjuvant chemotherapy after surgical resection has improved survival rates for patients with pancreatic ductal adenocarcinoma (PDAC). However, outside clinical trials, many operated patients still do not receive adjuvant chemotherapy due to clinical and tumor-related factors. The aim of this study was to investigate factors that may influence the receipt of adjuvant chem
We present a digital-to-time converter (DTC)-assisted fractional-N wide-bandwidth all-digital PLL (ADPLL). It employs a MASH ΔΣ time-to-digital converter (TDC) to achieve low in-band phase noise, and a wide-tuning range digitally-controlled oscillator (DCO). Fabricated in 40nm CMOS, the ADPLL consumes 10.7 mW while outputting 1.73 to 3.38 GHz (after a ÷2 division) and achieves better than -109 dBc
We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd-Chiari syndrome (BCS) and portal vein thrombosis were diagnosed in 31 (17.1%) and 109 (60.3%) patients, respectively; isolated thrombosis of the mesenteric or splenic veins was detected in
The outgrowth region of the regenerating frog sciatic nerve shows an increased permeability for various drugs, which has been utilized for pharmacological studies of axonal transport. Six days after a bilateral crush lesion, the nerves, including the spinal ganglia, were incubated in a compartmented chamber. Orthograde transport was assessed from the proximodistal distribution and the accumulation
NAD betyder Nätverk, Aktivitet och Delaktighet och är ett samarbete mellan Länsstyrelsen, Region Skåne, Arbetsförmedlingen och idéburen sektor via NÄTVERKET. NAD-projektet utvecklar aktiviteter som en del av den etableringsplan som Arbetsförmedlingen upprättar tillsammans med den nyanlända. Verksamheten handlar om att underlätta för nyanlända flyktingar att delta i oli
Cross section and S factor of the proton- and alpha-induced reactions have been studied for the Ruthenium and tin isotopes in the effective energy range, i.e. Gamow window. These reactions are important for developing the understanding for nucleosynthesis, particularly for the synthesis of p nuclei (p process). In this work, cross sections and S factor have been calculated through TALYS in Hauser–
The large rate of multiple simultaneous proton–proton interactions, or pile-up, generated by the Large Hadron Collider in Run 1 required the development of many new techniques to mitigate the adverse effects of these conditions. This paper describes the methods employed in the ATLAS experiment to correct for the impact of pile-up on jet energy and jet shapes, and for the presence of spurious addit
Optically stimulated luminescence (OSL) from ordinary household salt has proven high potential for very low dose retrospective dosimetry. In the present paper other common place materials are considered and their dosimetric OSL-properties compared with household salt. The potential for assessment of the effective dose to an individual carrying such materials is investigated.
Why do eye clinics differ in their waiting times for women’s and men’s access to cataract extraction (CE)/“grå starroperation”? Taking a doing-gender perspective as the starting point, this study explores how gender constructions embedded in Swedish eye clinics contribute to longer waiting times for women than for men. Focus group interviews were conducted with doctors at two Swedish eye clinics:
Acellular scaffolds from complex whole organs such as lung are being increasingly studied for ex vivo organ generation and for in vitro studies of cell-extracellular matrix interactions. We have established effective methods for efficient de and recellularization of large animal and human lungs including techniques which allow multiple small segments (~1-3 cm3) to be excised that retain 3-dimensio
OBJECTIVES: Outcome assessment in large-vessel vasculitis (LVV) remains challenging and this impairs patient management and the conduct of clinical studies. Previous proposals for outcome tools have not included imaging. This study aimed to develop an imaging score to quantify damage in LVV and to assess the difference between Takayasu (TAK) and giant cell arteritis (GCA).METHODS: Ninety-six patie
Objective: To study selective regional binding for tau pathology in vivo, using PET with [11C]PBB3 ([11C]methylamino pyridin-3-yl buta-1,3-dienyl benzo[d]thiazol-6-ol) in tauopathies, and in conditions not typically associated with tauopathy. Background: Tau imaging is a promising tool to study the link between tau and neurodegeneration. The specificity of tracers in vivo however remains uncertain
It would appear that all possible types of source material concerning pre-colonial and colonial Indian history had been found and analyzed only to be reanalyzed repeatedly, resulting in a number of macro-level studies. However, micro-level studies have been very rare. This may be so because many a historian of India believed that sources necessary for such studies did not exist as there was no tra
Enhanced heat transfer tubes (EHTT) with segmented mesh-conical frustums are considered. Tube diameter and frustum apex angle are fixed as 20 mm and 60o, respectively. The height ratio of frustum and sliced part are set as a golden ratio (1.618). Laminar thermal-hydraulic performance and effects of some parameters, e.g., bottom frustum diameter and pitch, are numerically simulated. The equal equiv
Objective: Estrogen receptor (ER) positive breast cancer (BC) can havean insidious course with disease-relapse decades after primary surgery.New analysis performed on archived formalin-fixed paraffin-embedded(FFPE) tissue are important for disease-management in late BC-relapseand an important tool in BC-research. However, although loss of immunoreactivityin tissue slides after sectioning has been
Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus. We analyzed the effects of ER-associated processes and factors on infection and on isolated viruses and found that SV40 makes use of the thiol-disulfide oxidoreductases, ERp57 and PDI, as well as
The extent to which humans help each other is extraordinary in itself, and difficult to explain from an evolutionary perspective. Therefore, there has been a recent surge in studies investigating the evolution of prosocial behavior using a comparative approach. Nevertheless, most of these studies have focused on primates only, and little is known about other animal orders. In a previous study, com
