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Ten per cent of the population in the western world suffer from osteoarthritis – a widespread endemic disease that is estimated to cost the Swedish society equivalent to two per cent of the Swedish GNP annually, corresponding to over 50 billion SEK in 2009 in treatments and lost productivity. With an increasing aging population the incidence of osteoarthritis is expected to be further enhanced. In
I denna fallstudie kartlades den totala expressiva, skriftliga kommunikationen hos en person med total talapraxi. Den skriftliga kommunikationen sträckte sig över två års tid. Syftet med kartläggningen var att utifrån forskningspersonens skriftliga kommunikation få ökad kunskap om möjligheten att använda bildbaserad AKK som ersättning för tal och hur den i så fall skulle kunna vara utformad. Kommu
Flera undersökningar har visat att arbetsminnet spelar en stor roll vid problemlösning, språkförståelse och långtidsinlärning. Eftersom den mesta forskningen hittills har gjorts på barn var vårt syfte att testa unga vuxna, vilket här innebär gymnasieelever i år 2 och 3. Testpersonerna var från 17:4 till 20:1 år. Vi ville få en inblick i hur unga vuxna kommer ihåg nya ord, som de hört i en kontext,
Social Work Education today places great importance to convey values such as respect in the relation between social worker and client, and to embrace a user perspective in the professional practice. Yet, many clients find themselves mistreated and ignored and experience social service work as arbitrary and inaccessible. The purpose of this study is to examine what takes place in the encounter betw
Populärvetenskaplig sammanfattning Spektroskopi handlar om teoretiska modeller och experiment där man observerar ljus som har växelverkat med materia. Spektroskopiska metoder används inom många olika ämnesområden som exempelvis kemi, fysik och biologi. Ett jordnära exempel på tillämpad spektroskopi är människans öga. Reflekterat ljus från olika föremål samlas in av linsen i ögat, avbildas på näthiIn this thesis a novel spectroscopic method consisting of a combination of frequency domain photon migration (FPDM) and gas in scattering media absorption spectroscopy (GASMAS) is developed, for assessment of the mean optical path length and gas absorption in porous media. The system stability is experimentally investigated and measurements are performed on balsa and pine wood to evaluate the rela
Förmannaansvar (command responsibility) är en form av straffansvar som utvecklats till största delen under 1900-talet och ger möjlighet att åtala militära befälhavare och andra överordnade för krigsbrott samt brott mot mänskligheten genom att bevisa tre rekvisit. Inledningsvis måste befälhavaren ha effektiv kontroll över den underordnade som begått brottet. Vidare krävs att befälhavaren innehar enCommand responsibility is a mode of criminal responsibility that developed mostly during the 20th century and provides the opportunity to charge military commanders and other superiors for war crimes and crimes against humanity committed by their subordinates by proving three criteria. To begin with, the commander must have exercised effective control over the subordinate, moreover the commander m
The Particle Finite Element Method (PFEM) is attractive for the simulation of large deformation problems, e.g. in free-surface fluid flows, fluid–structure interaction and in solid mechanics for geotechnical engineering and production processes. During cutting, forming or melting of metal, quasi-incompressible material behaviour is often considered. To circumvent the associated volumetric locking
Post-marketing reports of suspected adverse drug reactions are important for establishing the safety profile of a medicinal product. However, a high influx of reports poses a challenge for regulatory authorities as a delay in identification of previously unknown adverse drug reactions can potentially be harmful to patients. In this study, we use natural language processing (NLP) to predict whether
Background: Osteonecrosis (ON) is a potentially disabling skeletal complication of cancer treatment. Although symptomatic osteonecrosis (sON) is well-known in acute lymphoblastic leukemia (ALL), with an incidence around 6%, studies on sON in pediatric Hodgkin lymphoma (HL) are scarce. The aim of this study was to examine the incidence, risk factors, and outcome of sON in children treated for HL. P
Patients and families facing serious illness often want and need their clinicians to help guide medical decision making by offering a recommendation. Yet clinicians worry that recommendations are not compatible with shared decision making and feel reluctant to offer them. We describe an expert approach to formulating a recommendation using a shared decision-making framework. We offer three steps t
BACKGROUND: Residents struggle with advance care planning (ACP) discussions in the inpatient setting, and may not be aware of newer models for ACP that stress the importance of giving prognostic information and making a recommendation about cardiopulmonary resuscitation to patients and families.METHODS: A controlled study of a cognitive model for ACP embedded in a quality improvement (QI) project.
Accurate regulation of microfilament dynamics is central to cell growth, motility and response to environmental stimuli. Stabilizing and depolymerizing proteins control the steady-state levels of filamentous (F-) actin. Capping protein (CP) binds to free barbed ends, thereby arresting microfilament growth and restraining elongation to remaining free barbed ends. In all CPs characterized to date, a
Purpose: To ensure a clinical translation of FLASH radiation therapy (FLASH-RT) for a specific tumor type, studies on tumor control and toxicity within the same biological system are needed. In this study, our objective was to evaluate tumor control and toxicity for hypofractionated FLASH-RT and conventional radiation therapy (CONV-RT) in an immunocompetent rat glioma model. Methods and Materials:
This is a cartographic vertical analysis of a verdict by the Swedish Supreme Administrative Court, regarding the right to support from the Social Services (HFD 2017 ref. 33). The case concerned three children and their mother whom lacked formal residency. They applied for assistance under the Social Services Act and the municipality’s health and welfare committee rejected the application. Followin
aim: Approximately one in five patients with acute diverticulitis (AD) will experience a recurrence. This study aimed to investigate the factors at AD admission that correlate with recurrence and test the proposed risk of recurrence-score according to Sallinen et al. method: This retrospective study followed patients for five years who were admitted with operatively or computed tomography (CT)veri
Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It al
The CORDEX Flagship Pilot Study ELVIC (climate Extremes in the Lake VICtoria basin) was recently established to investigate how extreme weather events will evolve in this region of the world and to provide improved information for the climate impact community. Here we assess the added value of the convection-permitting scale simulations on the representation of moist convective systems over and ar
Predictions of cloud droplet activation in the late summertime (September) central Arctic Ocean are made using κ-Kohler theory with novel observations of the aerosol chemical composition from a high-resolution time-of-flight chemical ionization mass spectrometer with a filter inlet for gases and aerosols (FIGAERO-CIMS) and an aerosol mass spectrometer (AMS), deployed during the Arctic Ocean 2018 e
Objectives Heat-stressed Mesoamerican workers, such as sugarcane cutters, suffer from high rates of chronic kidney disease of non-traditional origin (CKDnt). We aimed to identify easily available early markers of rapid kidney function decline in a population at high risk of CKDnt. Design The accuracy of different biomarkers measured during harvest for prediction of cross-harvest kidney function de
Standardized Care Pathway (SCP) for patients presenting with macroscopic haematuria was introduced in Sweden in 2015. In contrast to neighbouring countries, the Swedish model includes all patients with macroscopic haematuria above the age of 50, notwithstanding obvious causes. The aim of this study was to characterize the patients referred within the SCP and the presence of acute cystitis.All pati
