Filetype
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has
The fertilizer industry is experiencing tremendous stress due to its dependence on limited natural resources and high energy consumption, thus great attention has been paid for alternative nitrogen and phosphorus resources. This study employed electrodialysis (ED) with sacrificial magnesium anode to recover nitrogen and phosphorus (towards struvite formation) from primary municipal wastewater and
This Letter presents results from a combination of searches for Higgs boson pair production using 126-140 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.4 assuming no Higgs boson pair production. Constraints
The diagnosis of lymphoma relies mainly on clinical examination and laboratory explorations. Among the latter, morphological and immunohistochemical analysis of a tissue biopsy are the cornerstones for proper identification and classification of the disease. In lymphoma with blood and/or bone marrow involvement, multiparameter flow cytometry is useful. This technique can also be applied to fresh c
Background: Negative affective processes may contribute to maintenance of paranoia in patients with psychosis, and vice versa. Successful treatment may break these pathological symptom networks. This study examined whether treatment with virtual reality based cognitive behavioral therapy (VR-CBT) for paranoia influences momentary affective states, and whether VR-CBT changes the adverse interplay b
This essay delves into the akiya (vacant houses) problem in Japan, using the phenomenon as a lens to discuss the larger issue of depopulation and repopulation of regional Japan. It builds on ethnographic fieldwork conducted in Kochi Prefecture from February to April, 2023, where semi-structured interviews were conducted with official workers and local residents of depopulated areas. The study find
In the Romance languages, definite plural articles (e.g., le rane ‘the frogs’) are generally ambiguous between a generic and a specific interpretation, and speakers must reconstruct the intended interpretation through the linguistic or extra-linguistic context. Following the “polar bear” paradigm implemented in Czypionka & Kupisch (2019)’s investigation on German, the goal of the present study
Introduction Management of testicular torsion varies between specialties resulting in lack of standardization. The aim of this survey was to assess pre-, peri-, and postoperative differences. Methods An online questionnaire was distributed in 2023 to general and pediatric surgeons, pediatric urologists, and urologists by the Trainees of European Pediatric Surgery. Main Results Among 88 respondents
The first part of the first volume of the Swedish Academy Dictionary (SAOB) was published in 1893 and the last volume was finished in 2023. Thus Sweden’s most extensive lexicographical project was completed after more than 130 years of work. But the completion is not the end of the dictionary project. Since 2024 a revision project is launched. In this paper the history of the dictioThe first part of the first volume of the Swedish Academy Dictionary (SAOB) was published in 1893 and the last volume was finished in 2023. Thus Sweden’s most extensive lexicographical project was completed after more than 130 years of work. But the completion is not the end of the dictionary project. Since 2024 a revision project is launched. In this paper the history of the dictio
Background: The Duke criteria for diagnosing infective endocarditis (IE) were recently updated by the International Society for Cardiovascular Infectious Diseases (ISCVID) with the purpose of enhancing diagnostic specificity and sensitivity. This study investigated the performance of the Duke-ISCVID criteria in relation to previous criteria. Method: This retrospective single centre cohort study in
This paper focuses on the meticulous selection of optimal remote sensing and climate datasets for Gross Primary Productivity (GPP) estimation in African rangelands. Utilizing Eddy Covariance Flux Tower data, we refine data selection and employ a Light Use Efficiency (LUE) model, with Sentinel 2 for photosynthetically active vegetation quantification, MODIS for Photosynthetically Active Radiation (
Objective: We investigated diagnostic utility of phosphorylated tau 217 and 181 (ptau217, ptau181), glial fibrillary acidic protein (GFAP), amyloid beta 42 and 40 (Aβ42, Aβ40), and neurofilament light (NfL) to distinguish biomarker-defined Alzheimer disease (AD) from non-AD conditions, in a heterogenous clinical cohort of younger people. Methods: Plasma biomarkers were analysed using ultrasensitiv
Organophosphate hydrolases are proficient catalysts of the breakdown of neurotoxic organophosphates and have great potential as both biotherapeutics for treating acute organophosphate toxicity and as bioremediation agents. However, proficient organophosphatases such as serum paraoxonase 1 (PON1) and the organophosphate-hydrolyzing lactonase SsoPox are unable to hydrolyze bulkyorganophosphates with
Aims: We aimed to create a predictive model utilizing machine learning (ML) to identify new cases of congestive heart failure (CHF) in individuals with diabetes in primary health care (PHC) through the analysis of diagnostic data. Methods: We used a sex- and age-matched case–control design. Cases of new CHF were identified across all outpatient care settings 2015–2022 (n = 9098). We included indiv
Background: We investigated whether psychosocial determinants self-efficacy and social support are associated with Health-Related Quality of Life in hemodialysis patients enrolled in the CONVINCE trial. Methods: We used baseline data from the cohort of patients involved in the CONVINCE randomized trial of hemodiafiltration versus hemodialysis. Measures included age, gender, relationship status, ch
Background: People with early axial spondyloarthritis experience a diagnostic delay and a similar disease burden as people with axial spondyloarthritis at a later stage of the disease. In many European countries, patients with early axial spondyloarthritis do not have access to an interdisciplinary rehabilitation team. The objective of this study was to develop a new evidence-based physiotherapist
The Fine Resolution Explorer for Salinity, Carbon and Hydrology (FRESCH) is presented. The science case and the mission objectives are discussed before presenting the mission concept. FRESCH is an L-band antenna array operated in beamforming mode providing data at a spatial resolution of 10-15 km to study the biogeochemical and physical phenomena taking place at the interfaces of ocean, land and i
Background and purpose: Although the diagnostic accuracy of 18F-fluorodeoxyglucose – positron emission tomography/computed tomography (18F-FDG-PET/CT) for breast cancer (BC) has been well studied, few studies have evaluated the impact of 18F-FDG-PET/CT on BC patient care. This study aimed to investigate restaging and 18F-FDG-PET/CT-induced changes in clinical decision-making in patients with BC. M
Glucuronic acid (GlcA) is an abundant substituent in hardwood xylan, and it is often found in its methylated form as methyl glucuronic acid (MeGlcA). GlcA and MeGlcA are sugar acids, bound to the xylose backbone at position O-2, and their presence can affect the digestibility of the polymer. Currently, detection of released GlcA or MeGlcA from synthetic substrates such as pNP-glucuronic acid can b
