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The conversion of lignin to potentially high-value low molecular weight compounds often results in complex mixtures of monomeric and oligomeric compounds. In this study, a method for the quantitative and qualitative analysis of 40 lignin-derived compounds using ultra-high-performance supercritical fluid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) has been

Background: Breastfeeding rates in Sweden are declining, and it is important to identify women at risk for early cessation of exclusive breastfeeding. Objective: The aim of this study was to investigate factors associated with exclusive breastfeeding lasting less than two months postpartum. Methods: A population-based longitudinal study was conducted at Uppsala University Hospital, Sweden. Six hun

Geocoding longitudinal and individual-level historical demographic databases enables novel analyses of how micro-level geographic factors affected demographic outcomes over long periods. However, such detailed geocoding involves high costs. Additionally, the high spatial resolution cannot be properly utilized if inappropriate methods are used to quantify the geographic factors. We assess how diffe

Background: Diabetic foot ulcers are a common and severe complication of diabetes mellitus. Standard treatment includes debridement, offloading, management of infection and revascularisation where appropriate, although healing times may be long. The LeucoPatch® device is used to generate an autologous platelet-rich fibrin and leucocyte wound dressing produced from the patient's own venous blood by

Monoterpenoid indole alkaloids (MIAs) are produced as plant defence compounds. In the medicinal plant Catharanthus roseus, they comprise the anticancer compounds vinblastine and vincristine. The iridoid (monoterpenoid) pathway forms one of the two branches that feed MIA biosynthesis and its activation is regulated by the transcription factor (TF) basic helix-loop-helix (bHLH) iridoid synthesis 1 (

Co-creation (or co-production, Voorberg et al., 2015) of public services together with individual service users is based on the assumption that the individual can define her or his own value to be co-created. However, in the case of children, this can be put into doubt, as children do not have the same cognitive perspectives and abilities as adults, and a weaker voice as agents. This results in thCo-creation (or co-production, Voorberg et al., 2015) of public services together with individual service users is based on the assumption that the individual can define her or his own value to be co-created. However, in the case of children, this can be put into doubt, as children do not have the same cognitive perspectives and abilities as adults, and a weaker voice as agents. This results in th

Hydropower makes up nearly half of Sweden's electrical energy production. However, the distribution of the water resources is not aligned with demand, as most of the inflows to the reservoirs occur during the spring flood period. This means that carefully planned reservoir management is required to help redistribute water resources to ensure optimal production and accurate forecasts of the spring

BACKGROUND AND PURPOSE: Treatment of cancer with immune checkpoint inhibitors (ICIs) entails a risk of immune-related adverse events (irAEs). Data on the treatment of immune-related enterocolitis (irEC) in patients with inadequate symptom control after treatment with standard therapy including corticosteroids, infliximab, and vedolizumab are scarce. Based on limited data, recommendations include t

The European Association of Urology (EAU) 2021 prognostic model for non–muscle-invasive bladder cancer (NMIBC) is based on the World Health Organization (WHO) 1973 and/or WHO 2004/2022 grading systems for patients who did not receive bacillus Calmette-Guérin (BCG) instillations and is widely used to assess the risk of progression. The estimated risk of progression affects the type of adjuvant intr

Climate change can raise average temperatures and humidity and induce more frequent and stronger extreme weather events. This intensifies the need for studies on indoor climate and energy use in livestock buildings as it will affect animal welfare and farmers’ economy in terms of production, energy demand and needed investments. The aim of this review was to identify knowledge gaps and the need fo

Background: Intra- and interfractional variations in anatomy can cause unplanned substantial alterations of the dose distribution of the target in proton therapy. Motion management methods might be used in order to minimize anatomical variations. In the proton therapy of lung cancer, a potential motion management technique is the use of the voluntary breath-hold approach. The aim of this study was

Machine learning methods have a groundbreaking impact in many application domains, but their application on real robotic platforms is still limited. Despite the many challenges associated with combining machine learning technology with robotics, robot learning remains one of the most promising directions for enhancing the capabilities of robots. When deploying learning-based approaches on real rob

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are becoming an increasingly global concern. PFASs are highly fluorinated organic chemicals that represent a serious risk for environmental and human health. Due to their toxicological impact, PFASs are now included in several emission regulations. Even if the global level of PFASs use is decreasing much of present concentrations in the environ

Amplification of the MYCN proto-oncogene serves as a key marker of aggressive disease and poor treatment outcomes in certain pediatric tumors originating from the nervous system, including neuroblastoma and medulloblastoma. However, the complex nature of the challenging MYCN protein underscores the urgent need for additional targets and therapies to tackle neuroblastoma and medulloblastoma. In thi

Water resource recovery facilities face challenges with increasingly stringent effluent demands, complexity and demand for capacity increasing investments. Emerging technologies such as digital twins could alleviate these problems but require high frequency influent data. This work presents a method for utilising measurements in the primary clarifier effluent with a model of the processes between

The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia