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Breast cancer is the most common cancer form among women in the Western world. Although treatment has improved during the last decades, there is still a significant proportion of the patients who are not cured. To further improve clinical outcome we need new treatment strategies, new prognostic markers, and new treatment predictive factors for personalized medicine.In this dissertation I have focu
High uncertainties are common in detailed quantification of the N budget of agricultural cropping systems. The process-based CoupModel, integrated with the parameter calibration method known as Generalized likelihood uncertainty estimation (GLUE), was used here to define parameter values and estimate an N budget based on experimental data from an organic farming experiment in south-west Sweden. Da
Background: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein interactions to elucidate risk independent of LD and to place the genetic association into a functional
In recent years, the mutational status of the KRAS oncogene has become incorporated into standard medical care as a predictive marker for therapeutic decisions related to patients with metastasized colorectal cancer. This is necessary, because these patients benefit from epidermal growth factor receptor (EGFR)-targeted therapy with increased progression-free survival only if the tumor does not car
The World Health Organization has a standardized tool to assess surgical capacity in low- and middle-income countries (LMICs), but it is often resource- and time-intensive. There currently exists no simple, evidence-based measure of surgical capacity in these settings. The proportion of cesarean deliveries in regard to the total operations (C/O ratio) has been suggested as a way to assess quickly
We study the mechanical failure of cemented granular materials (e.g., sandstones) using a constitutive model based on breakage mechanics for grain crushing and damage mechanics for cement fracture. The theoretical aspects of this model are presented in Part I: Tengattini et al. (2014), A thermomechanical constitutive model for cemented granular materials with quantifiable internal variables, Part
Technology foresight studies have become an important tool in identifying realistic ways of reducing the impact of modern energy systems on the climate and the environment. Studies on the future cost development of advanced energy technologies are of special interest. One approach widely adopted for the analysis of future cost is the experience curve approach. The question is, however, how robust
A search is presented for a high-mass Higgs boson in the , , , and decay modes using the ATLAS detector at the CERN Large Hadron Collider. The search uses proton-proton collision data at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 20.3 fb. The results of the search are interpreted in the scenario of a heavy Higgs boson with a width that is small compared with the
Aim: To compare treatment costs with alternative luteinizing hormone-releasing hormone (LHRH) agonist preparations and determine whether a leuprorelin solid implant is associated with potential cost savings. Patients & methods: A hypothetical population of 1000 prostate cancer patients was apportioned between the three most commonly-prescribed LHRH agonist preparations. Differentiated annual c
BACKGROUND AND PURPOSE: We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003. METHODS: All 78 hospitals in Sweden admitting patients with acute stroke participate in Riks-Stroke. Between 2003 and 2008, 72 033 adult patients were hospitalized for acute ischemic stroke. We analyzed thrombolysis use by r
Preservation of digital records is still very much an open issue within large parts of the Swedish public sector. An ongoing work of coordinating the digital preservation in the public sector is carried out by the Swedish National Archives, but, as of yet, the results are limited, and much remains to be done. The issue of digital preservation is also inherently one that will require a lot of diffe
Abstract The world has seen three industrial revolutions and now it embraces the fourth. The fourth industrial revolution, (globalisation 4.0) or as this study uses industry 4.0, follows onto the third industrial revolution by connecting digital, material and living spheres. The narrative of Africa rising, and the related expansion of mobile phone motivated the thesis interest. As past development
Technological advancements continue to drive changes in our modern society. To keep up with these changes, it is of utter importance to stay competitive, whilst remaining flexible enough to be prepared for future changes. A sector which has struggled in this aspect, traditionally, is self-employed craftsmen - individuals who run a business based upon an aptitude for their trade. This study focuses
Payment for water ecosystem services has been gaining attention in Latin America because of the direct response for environmental conservation through economic mechanisms. By connecting nature services with people who benefit from them, it creates a sustainable intervention for the ecosystem’s management while enhancing human well-being according to policy implementers. Nevertheless, these initiat
Moving towards circular economy is considered as a fundamental way to achieve sustainable development, but practices and tools that can support businesses in implementing this concept are still underdeveloped. Moreover, there is uncertainty about the impact that the adoption of circularity has on the current way of working of a company. With the adoption of aspects of action research on a rock and
Sverige har varit skyldig att uppfylla de krav som barnkonventionen ställer upp sedan ratificeringen år 1990. Trots det har barnrättskommittén riktat kritik mot Sverige för att inte fullt ut göra det. För att stärka barnets rättigheter i enlighet med barnkonventionen har Sveriges riksdag röstat igenom förslaget om att anta barnkonventionen som svensk lag den 1 januari 2020. Med ett barnrättsperspeSweden has been obliged to comply with the requirements of the UN Convention on the Rights of Child since the ratification in year 1990. In spite of this, the Committee on the Rights of the Child has criticized Sweden for not fully doing so. To strengthen the rights of the child in accordance with the Convention, the Swedish Parliament has voted to approve the adoption of the Convention as a Swedi
Enligt nationella föreskrifter ska vindkraftverk över 150 m i totalhöjd markeras med högintensivt vitt blinkande ljus för att säkerställa att vindkraftverken är synliga för luftfarten. Samtidigt som hinderbelysningen är viktig för flygsäkerheten kan dock ljuset upplevas som störande av närboende. Syfte med denna studie är därför att utreda konflikten mellan vindkraftsetableringar och närboendes häAccording to national regulations, wind turbines over 150 m in total height must be marked with high-intensity white flashing light to ensure that the wind turbine is visible to aviation. However, while the obstacle lighting is important for aviation safety it can also be perceived as disturbing to nearby residents. The purpose of this study is therefore to investigate the conflict between wind po
I svensk rätt finns ingen arvsrätt för sambor. Om samborna har bröstarvingar saknar de möjlighet att testamentera hela kvarlåtenskapen till varandra på grund av bröstarvingarnas rätt att få ut sin laglott. Uppsatsens syfte är att diskutera efterlevandeskyddet för sambor och om det är ändamålsenligt givet en modern syn på samboskap. Genom att studera gällande rätt och förarbeten identifieras vilkIn Swedish law, there is no right of inheritance for unmarried cohabitants. If the cohabitants have direct heirs, the cohabitants lack the opportunity to leave their entire estate to each other due to the heirs’ right to receive their statutory share of inheritance. The aim of this essay is to discuss the survivors’ protection for cohabitants and whether it is appropriate given a modern interpret
I betänkandet En stärkt rättsprocess och en ökad lagföring (SOU 2021:35), vilket publicerades den 25 maj 2021, föreslogs att det borde införas en strafflindringsgrund avseende medverkan till utredning av annans brottslighet. Förslaget innebär en avvägning mellan å ena sidan effektiv brottsbekämpning och å andra sidan rättssäkerhet. Syftet med uppsatsen är att, utifrån ett rättssäkerhetsperspektiThe report En stärkt rättsprocess och en ökad lagföring (SOU 2021:35), which was published on 25 May 2021, proposed that an arrangement which provides a possibility for the court, when sentencing, to take into consideration the fact that the accused has assisted in the investigation of serious criminality committed by another person should be introduced. The proposal strikes a balance between effe
