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P-type ATPases from the P4 subfamily (P4-ATPases) are energy-dependent transporters, which are thought to establish lipid asymmetry in eukaryotic cell membranes. Together with their Cdc50 accessory subunits, P4-ATPases couple ATP hydrolysis to lipid transport from the exoplasmic to the cytoplasmic leaflet of plasma membranes, late Golgi membranes, and endosomes. To gain insights into the structure
Background: Gallbladder cancer is a rare neoplasm with a poor prognosis. Early diagnosis and correct treatment strategy is important. The aim of this study was to identify predictors for incidental gallbladder cancer. Methods: Data from cholecystectomies registered in the nationwide Swedish Register for Gallstone Surgery between 2007 and 2014 were analyzed for incidental gallbladder cancer. Exclus
Previous research on collaboration in social work practice shows that conflicts among collaborating authorities and organizations and that include cooperating actors are common. In this study, I have analyzed a successful dimension of the phenomenon “cooperation.” The purpose of the study is to analyze examples of successful cooperation in Swedish social work practice. This study presents an analy
The wage book of a Derbyshire farm, which includes payments to laborers for 1772 to 1775 and 1831 to 1845, allows me to examine the employment patterns of male and female day-laborers at this farm before and after important innovations in agriculture. I find a fall in relative female employment which appears to be due to a fall in demand. Male employment shifted to the spring, but female employmen
During the last two decades or so, film support, film policy and the public financing of audiovisual production in Scandinavia and particularly Sweden have undergone extensive transformation. In diverse ways, these changes can be seen as responses to globalization, to increased sub-national regional independence as well as to the emerging idea of nurturing ‘creative industries’ taking hold. They m
Heavy-ion collisions at high energies calls for new technical solutions to cope with the very high multiplicities of produced particles. In this thesis the design and development of two types of tracking chambers for high multiplicity environments are presented. The first type was developed to be a part of the tracking system of the WA98 experiment. The tracking chambers were designed to provide
A chemotaxonomic method for classification of asymmetric penicillia by means of cross-partition in aqueous two-phase systems combined with SIMCA pattern recognition analysis. Conidia of three strains each of three closely related Penicillium species in the P. oiridicatum group were subjected to cross-partition in aqueous polymer two-phase systems. The cross-point values, the percentage of conidia
Objective. To investigate the adjusted relative risk of cardiovascular disease (CVD) events in offspring of parents with cardiovascular mortality before 75 years. Setting. The city of Malmö, Sweden. Design. A follow-up study based on register linkage analyses. Subjects and methods. In the Malmö Preventive Project (MPP), a total of 22 444 men and 10 902 women attended the screening programme bet
Popular Abstract in Swedish Forskning och studier av ytvattensystem i sudanesiska röda havsområdet för utveckling av relevant metodik medför ett antal konceptuella svårigheter. Ett huvudsakligt problem är den begränsade tillgången till litteratur och mätdata för modellutveckling. En annan svårighet är tillämpligheten av redan existerande metoder och modeller utvecklade i andra regioner. För att bThe magnitude and availability of surface waters in the arid/semi-arid Sudanese Red Sea region has been examined. In conjunction with the research objective, opinions and methodologies applied by previous researchers have been assessed. The study applied a geographical hydrological synthesis within a GIS framework. As a system with advanced geo-modelling capabilities, GIS is used to integrate spat
In osteoarthritis (OA), cartilage and bone fragments have been described within the synovial tissue which are surrounded by synovial cells (i.e. detritus synovitis). These cells appear to attach actively to the cartilage and bone fragments. In rheumatoid arthritis (RA), on the other hand, synovial fibroblasts (SF) have also been shown to be localized at sites of invasion into cartilage and bone an
After time-consuming and costly investigations, patients with neck metastases from an occult primary often receive unnecessarily large radiation volumes to treat a possible origin in the nasopharynx. In this study a colorimetric antisense Epstein-Barr early ribonucleoprotein 1 (EBER1) oligonucleotide probe specific for Epstein-Barr virus RNA was hybridized in situ to metastatic tissue obtained fro
Pt (0.1 wt.%) on Al2O3, TiO2, and MgO supports were used for the low temperature combustion of methanol in both the absence and the presence of ammonia. Without NH3 in the gas the performance for the complete combustion decreases in the order Pt/MgO greater than or equal to Pt/TiO2 much greater than Pt/Al2O3 comparing a fixed amount of Pt surface area. In the presence of ammonia strong deactivatio
OBJECTIVE: To compare costs of transurethral prostatic resection (TURP) and transurethral microwave thermotherapy (TUMT) for symptomatic benign prostatic hyperplasia (BPH) in a randomized, controlled trial. METHODS: In 70 BPH patients all costs were calculated for management, including complications and repeat treatment, during TURP or TUMT and 24-month follow-up. Clinical outcome was judged from
Some patients with hearing impairment cannot use conventional hearing aids. One solution for these patients is the use of bone conduction hearing aids; however, this kind of equipment is associated with several problems related to the necessity for a good contact between the transducer and the temporal bone. Direct bone contact would be an ideal solution provided that safe and reaction-free skin p
Introduction: Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5-20% of subjects with a spine fracture are identified in primary care. We aimed to develop easily applicable algorithms predicting a high risk of future spine fracture in men and women over 50 years of age. Methods: Data was analysed from 5,561 men and women aged 50+ year
In this study, a method was developed for determination of the free concentration of 4-isobutylacetophenone, a toxic degradation product of ibuprofen, in river and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid-liquid extraction (HF-MMLLE) set-up and gas chromatography-mass spectrometry (GC-MS), respectively. In this n
