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Characterization of CD8+ T cell subtypes induced by 4-1BB costimulation in mice

Aktivering av immunförsvaret dämpar den samme Kroppens immunförsvar består av en mängd olika typer av specialiserade celler, alla med sina unika egenskaper och nischer. För att immunförsvaret ska fungera så optimalt som möjligt krävs det att cellerna kan interagera och kommunisera med varandra, vilket görs med hjälp av proteiner som finns på cellernas yta. En typ av celler, som kallas CD8+ T cellAbstract 4-1BB (CD137/TNFRSF9) is a costimulatory receptor expressed by several cellular subsets of the immune system, but is commonly associated with CD8+ T cells. Stimulation of 4-1BB on CD8+ T cells with agonistic antibodies (α-4-1BB) causes a potent proliferation signal and an upregulated expression of CD11c. CD11c+CD8+ have previously been recognized to suppress other immune cells, such as F

"De är människor, men jag är något annat": En intervjustudie om hur porrmissbruk kan se ut

The purpose of this paper was to examine how five persons who identify themselves as porn addicts view their addiction in terms of how the addiction have come about, what affective experiences they associate with the addiction, how it affects their relations to others, what makes them continue using pornography, what forms the addiction takes and how they live with their addiction today. Based on

Försäkringsbolagets lojalitetsplikt

I denna framställning behandlas fyra huvudsakliga frågeställningar beträffande den avtalsrättsliga lojalitetsplikten som försäkringsbolag har att beakta i företagsförsäkringsavtal. Beträffande den fösta frågeställningen, vad lojalitetsplikten i dessa avtal grundas på, kan följande konstateras. Plikten innebär att parterna med omsorg har att iaktta och tillvarata motpartens intressen i avtalsförhThis presentation deals with four main issues concerning the contractual duty of loyalty which insurance companies have to consider in business insurance agreements. Regarding the first question at issue - what the duty of loyalty in these agreements is based on - the following can be stated. The duty implies that the parties with care observe and exploit the counterparty’s interests in the cont

Familjeägda aktiebolag - skydd av ägarpositioner

Uppsatsen behandlar frågan om skydd av ägarpositioner i anslutning till familjeägda aktiebolag. Anledningen till uppsatsens tema är att familjeägda aktiebolag har en särprägel som avviker från det efter ABL konstruerade aktiebolaget. Detta uttrycks, till exempel genom att ägarna i det familjeägda bolaget vanligtvis har ett särskilt behov av att skydda ägarkretsens sammansättning under en längre peThis paper is on protection of ownership positions in relation to family-owned businesses. The reason for the papers theme is that family-owned businesses have a distinctive character that deviates from the construction in the Companies Act. For example, owners of a family-owned business usually have a particular need to protect the ownership structure for a longer period of time. To put the famil

Punching Below its Weight? The European Union @ the United Nations General Assembly

The thesis explores and analyses the behaviour of the European Union vis-à-vis the promotion and protection of human rights within the United Nations General Assembly (UNGA). It furthermore examines whether the theory of ‘normative power Europe’ is an appropriate theory in characterizing the external action of the EU at the UNGA. Drawing on seven interviews with EU and non-EU officials in both New

Playing the Reality: Screen Projections during Depeche Mode's Concert "Touring the Angel: Live in Milan"

This thesis investigates the video projections that are presented on screens during live music performances through a case study focusing on the Touring the Angel concert by Depeche Mode. The concert took place in Milan and was released on DVD in 2006. Video projections during live concerts combine images that were produced before, such as video clips and still photography, with shots from the sta

Reflections on “the Present”. Culture. Politics. Globalization.

This is an inquiry into how aspects of the present human reality came to being and thereby also an investigation into limitations and potentialities of this “present”. An important argument in this essay is that there exists a mutually affective relationship between culture and politics and that this relationship implies both possibilities and constraints. With this in mind I try to critically inv

Wind effects on high rise buildings.

The wind effects on high rise buildings were studied by finding and reading books, articles and studying equations. This was done to calculate the first natural frequency of high rise buildings, wind induced acceleration on high rise buildings and how the comfort criteria of acceleration performing on high rise buildings acts on human bodies living in the building. The buildings that were studied

Construction of an Instrument to Use Nanoparticles for Diffusion Capacity Measurements in Human Alveolar Regions for Diagnostics of Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease (COPD) was ranked as the sixth leading cause of death in 1990 and is projected to be the fourth leading cause of death worldwide by 2030 due to an increase in smoking rates and demographic changes in many countries (Mathers & Loncar 2006). To diagnose COPD there are several methods which are either imprecise or very expensive. The objective of this master

Att odla, att vattna, att vårda- En fallstudie om att behålla talanger i ett detaljhandelsföretag

Titel: Att odla, att vattna att vårda – En fallstudie om att behålla talanger i ett detaljhandelsföretag Nivå: Kandidatuppsats Institution: Service Management, Campus Helsingborg, Lunds Universitet Författare: Nina Nilsen Rydeback, Karolina Scherdin,Mathilda Welin Brook Bakgrund: Detaljhandeln är en bransch som traditionellt sett präglats av kompetensproblem. Branschen har beskrivits som en genomg

Tre sensvekofenniska graniter : kontakt- och åldersrelationer samt förekomst av metasedimentära enklaver

I den svekofenniska provinsens centrala region har granitoider som är tidig-, sen-, post- och anorogena intruderat metasedimentära bergarter (Härnögnejs) av varierande metamorf grad. Fältarbetet för denna undersökning utfördes i den södra delen av ett 15 x 15 km stort och rundat sensvekofenniskt granitmassiv ca 10 km väster om Örnsköldsvik. Här förekommer tre olika graniter som i detta arbete kalIn the central region of the Svecofennian Province, granitoids related to different stages of the the Svecofennian orogeny have intruded metasediments (Härnö gneiss) of varying metamorphic grades. The fieldwork of this project was carried out in Ångermanland about ten km to the west of Örnsköldsvik. The mapping area is situated in the southern part of a 15×15 km rounded late Svecofennian multi-in

Häxprocesserna i Europa

De stora häxprocesserna i Europa ägde rum under 1400- till 1700-talet. Framställningen avser att besvara hur den juridiska processen mot häxeriet var utformad samt förklara hur häxförföljelserna kunde uppstå. Den inkvisitoriska processen var karaktäristisk för häxprocesserna. I motsats till den ackusatoriska processen kunde domaren ta initiativ till rättsliga processer och låta makthavarnas ideoloThe witchcraft trials in Europe took place from the 15th to the 18th century. The purpose of this presentation is to clarify the model of the legal process against the witches and give an explanation of how the witch hunts started. The inquisitorial process was characteristic for the witchcraft trials. As opposed to the accusatory process, the judge could initiate the process and let the ideologie

Produktionslayout och lagersystem – En studie vid ALP Fasader AB

För att kunna föreslå förbättringar i ALP: s produktionslayout insåg vi rätt tidigt att det första steget för detta arbete var att sätta sig in i företagets produkter och hur de tillverkas. Vi inledde därför vårt arbete med en kartläggning av produktionen och dess olika produktionslinjer. Med detta som grund fortsatte vi sedan med att föreslå en ny layout, samt förbättringar i delar knutna till de

Plan A - A Study of the Climate Change Adaptation Perspective in the Planning and Building Act (2010:900)

Klimatförändringen är ett fenomen som på ett aldrig tidigare skådat sätt kommer att sätta press på rättssystem världen runt. Det finns ett behov av att utforma rättsliga instrument och institutioner för att hantera förändringar i miljön men också av att utforma själva lagstiftningen att vara flexibel och anpassningsbar i förhållande till föränderliga förhållanden i naturens tillstånd. För att säkeClimate change is a phenomenon that in an unprecedented way will put pressure on the legal systems worldwide. Not only is there a need for designing the necessary legal instruments and institutions to handle changes in the environment but also for the law itself to be flexible and able to adapt under preconditions in nature which are uncertain. To ensure that the legislation is resilient enough to

Albania - Targeting Foreign Direct Investments To Extractive Industry Through Fiscal Policy

Abstract This study aims to study the policies and measures adopted in order to attract FDIs to the extractive industry and to maximize their effects on the Albanian economy. Emphasis is put on fiscal policy and the allocation of tax revenues received from FDIs in the extractive industry. To conduct the study I have used theories explaining the reason behind FDI decisions and the mainstream theori

An analysis of the relationship between foreign trade and economic growth in Turkey over the period 1980-2009

This study analyzes the relationship between foreign trade and economic growth in Turkey during the last three decades while particularly observing distinctive feature of the last decade in terms of economic growth-foreign trade relationship. The study adopts two main methodological approaches. The first approach includes two econometric analyses based on VAR and VEC models regarding periods 1987: