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Background: Tracheal intubation is a high-risk procedure in the critically ill, with increased intubation failure rates and a high risk of other adverse events. Videolaryngoscopy might improve intubation outcomes in this population, but evidence remains conflicting, and its impact on adverse event rates is debated. Methods: This is a subanalysis of a large international prospective cohort of criti

The neutral protease cathepsin G belongs to a family of hematopoietic serine proteases stored in the azurophil granules of the neutrophil granulocyte. To investigate the function of asparagine-linked carbohydrates in neutrophil serine proteases, we constructed a mutant cDNA, coding for human cathepsin G deficient of a functional glycosylation site, for use in a transgenic cellular model. Wild type

Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna

Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the associatio

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of termin

BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the preferred treatment of peritoneal carcinomatosis (PC) of colorectal carcinoma. Patients with positive lymph node status have worse survival after CRS-HIPEC, which is probably due to higher rates of systemic failure. In this study, we analysed the effect of administration and timing of systemic chemot

AIM: We aimed to study the importance of erbB2 status in early stage postmenopausal breast cancer for patients who participated in a trial of five vs. two years of adjuvant tamoxifen.PATIENTS AND METHODS: We analysed the erbB2 status of the tumours from 577 patients participating in the trial, either by a DNA amplification assay (n = 181) or by measurement of the protein level with flow cytometry

BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison,

This enquiry discusses the potential of a large number of linguistic theories, approaches, concepts etc. from Plato to usage-based linguistics for the understanding of the tense system in Ancient Greek, and particularly in the Greek of the New Testament. It is argued that many significant insights within linguistics in the period from the earliest beginning of linguistic thought up to Saussure hav

PURPOSE: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.EXPERIMENTAL DESIGN: The efficacy of HDACi

This article introduces a new method to design with older people: unfettered design. We discuss three points of concern with existing methods of involving older users: unspecific design outcomes, prejudiced views on older users, and underlying power asymmetries, which can diminish the innovative capacities of the older adults involved. To overcome these issues, we argue for the benefits of adoptin

Popular Abstract in Swedish Denna studie har gått ut på att relatera litogeo- kemin (= kemin i bergarter) kring Stollbergs järn- och sulfidmalmsfält i Bergslagen till mineralogi och geologisk utveckling. Bergarterna kring Stollberg, liksom kring nästan alla andra järn- och sulfidmalmer (Cu, Pb, Zn) i Bergslagen, utgörs av vulkaniska bildningar. De vulkaniska bergarterna och tillhörande malmer bilThe Paleoproterozoic Fe-Pb-Zn-Mn(-Ag) Stollberg deposit is situated in the Bergslagen region of south-central Sweden. 6.65 Mt of sphalerite, galena and manganiferous skarn magnetite ore occur as disseminations and semi-massive to massive ore bodies hosted by volcanogenic sediments and carbonate rocks. Field relations, mineralogy and geochemistry suggest that the felsic volcanic rocks at Stoll- be

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have

Popular Abstract in Swedish Humant immunbristvirus (HIV) orsakar förvärvat immunbristtillstånd (AIDS). HIV/AIDS-epidemin har hittills innefattat över 60 miljoner människor som har infekterats och över 30 miljoner av dessa har avlidit i AIDS. HIV-infektion smittar via blod, sexuellt och från mor till barn vid graviditet eller via bröstmjölk. Vid infektion infogas virusets arvsmassa i den infekteradHIV-1 is dominating the global HIV pandemic, while HIV-2 is mainly confined to West Africa. The highest HIV-2 prevalence figures have been reported from Guinea-Bissau. While HIV-1 infection almost invariably leads to progressive immune dysfunction and AIDS, HIV-2 infection is characterised by a smaller proportion of individuals with disease progression to AIDS. In order to monitor the long-term e

Popular Abstract in Swedish ”Practice variation” I den kliniska vardagen ser man ofta slående variationer i handläggningsrutiner mellan läkare och vårdcentraler utan att detta kan förklaras av skillnader i sjuklighet hos patienterna. Dessa oförklarade skillnader benämns ”practice variation” och beror på lokalt förankrade rutiner ofta etablerade sedan länge. De är sällan vetenskapligt underbyggda uBackground and Aims: Differences in the clinical care of patients have been explained through the concept of practice variation, that is, the occurrence of established local medical procedures that varies between geographic areas. The primary measures introduced to eliminate undesirable differences in medical care are the introduction of medical guidelines and economical incentives that rewards th

Popular Abstract in Swedish Total höftledsplastik är en vanlig och mycket framgångsrik behandling av smärttillstånd i höftleden. Enligt svenska höftplastikregistret opererades 12651 patienter år 2002 men 1056 patienter fick samma år genomgå ett utbyte av sin höftledsprotes (revision). Att höftleden vrids ur led (luxation) upprepade gånger eller infektion kan vara orsaken till revision men det vanlTotal hip arthroplasty is a very successful procedure. Despite this fact, however, a certain portion of patients has to be revised. One major reason for revision is the wear of the polyethylene leading to loosening and osteolysis. The overall aim of this thesis was to evaluate linear wear and migration of cemented, all - polyethylene sockets and polyethylene liners in total hip arthroplasty. The a

Popular Abstract in Swedish Den övergripande målsättningen med denna avhandling har varit att undersöka molekylära förändringar i icke läkande venösa bensår. Framförallt har fokus lagts på faktorer som underhåller den ständigt pågående inflammationen i venösa sår. Med tanke på att alla venösa sår alltid koloniseras av olika bakterier, har vi undersökt hur bakterier kan påverka sårläkning och inflaChronic skin ulcers are a major health problem and an increasing burden on health care providers. These ulcers have various underlying causes, such as venous or arterial insufficiency, diabetes, or vasculitis. Non-healing venous leg ulcers represent a condition characterized by excessive inflammation and presence of bacteria. The overall aim of this thesis has been to explore the pathogenesis of t

Hereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. The mutation causes an amino acid substitution Leu68 -> Gln in cystatin C (L68Q cystatin C) which results in deposition of the protein in the blood vessel

Popular Abstract in Swedish Gående som mellanmänsklig handling Traska, spatsera, flanera, power-gå, ila, dra fötterna efter sig, ta en stärkande promenad eller bara vandra bort i tankarna för en kort stund. Att gå är en komplex handling som omfattar allt från upplevelsen av marken som vi går på till människorna vi möter. Både när vi är ute och går själva eller tillsammans med andra så förhåller vThere is a lack of attention toward the diversity in experiences of architecture that are expressed through walking. Through the application of autoethnography and critical perspectives of queer and feminist theory, this dissertation develops a method for investigating experiences of architecture in regard to the activity of walking. In addition, this thesis addresses the influence of form, materi