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PURPOSE: Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biological signature developed in this study provides recurrence risk and predicts radiotherapy (RT) benefit for DCIS patients following breast-conserving surgery (BCS)

The prospect of death influences people’s thoughts about and how they deal with their remaining time. We aimed to understand whether patients with progressive, life-limiting diseases are oriented in the past, present, or future and how they deal with temporality. We conducted 57 in-depth interviews with end-of-life patients in 10 countries using thematic analysis at three levels (i.e., locally in

Background: Tracheal intubation is a high-risk procedure in the critically ill, with increased intubation failure rates and a high risk of other adverse events. Videolaryngoscopy might improve intubation outcomes in this population, but evidence remains conflicting, and its impact on adverse event rates is debated. Methods: This is a subanalysis of a large international prospective cohort of criti

PURPOSE: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.EXPERIMENTAL DESIGN: The efficacy of HDACi

This article introduces a new method to design with older people: unfettered design. We discuss three points of concern with existing methods of involving older users: unspecific design outcomes, prejudiced views on older users, and underlying power asymmetries, which can diminish the innovative capacities of the older adults involved. To overcome these issues, we argue for the benefits of adoptin

The neutral protease cathepsin G belongs to a family of hematopoietic serine proteases stored in the azurophil granules of the neutrophil granulocyte. To investigate the function of asparagine-linked carbohydrates in neutrophil serine proteases, we constructed a mutant cDNA, coding for human cathepsin G deficient of a functional glycosylation site, for use in a transgenic cellular model. Wild type

Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna

Background and Objectives Postanoxic electrographic status epilepticus (PSE) affects up to a third of all comatose patients after cardiac arrest (CA) and is associated with high mortality. Late PSE onset (>24 hours), from a restored continuous background pattern, and absence of established indicators of poor outcome at multimodal prognostication are described in survivors. We aimed to determine th

BACKGROUND: Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors.PATIENTS AND METHODS: We included 167 483 participants from two prospective US

This document is a position statement from the Society for Cardiovascular Magnetic Resonance (SCMR) on recommendations for clinical utilization of cardiovascular magnetic resonance (CMR) in women with cardiovascular disease. The document was prepared by the SCMR Consensus Group on CMR Imaging for Female Patients with Cardiovascular Disease and endorsed by the SCMR Publications Committee and SCMR E

Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1–2 or mRS 0–3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, E

This article investigates the generation of online representations of older people by institutions. Specifically, it discusses the ways in which public sector organizations generate online representations of older people from a production perspective. This article uses the following questions to frame its analysis: What do we know about online representations of older people generated by public se

Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the associatio

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of termin

Lunds universitet Box 117, 221 00 Lund, Medicon Village Scheeletorget 1, Telefon +46 46 222 30 32 +46 46 222 00 00 E-post cecilia.gagne@fs.lu.se Forskarutb i ldn ingsnämnden Verksamhetsplan för forskarutbilningsnämnden (FUN) vid Lunds universitet 2022–2023 Enligt Arbetsordning för Lunds universitet 2.13 § ska Forskarutbildningsnämnden ”behandla strategiska utbildningsfrågor på forskarnivå som på g

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-06/Verksamhetsplan_FUN_Lunds%20universitet%202022%E2%80%932023.pdf - 2026-05-20

Terminologi inom informationssäkerhetsområdet | Medarbetarwebben Terminologi för informationssäkerhet vid Lunds universitet, Rev 2.0 210622 1 Terminologi – Informationssäkerhet Term Definition administratör (IT-system) Användare som har högre eller andra rättigheter än en vanlig användare, t.ex. systemadministratör, säkerhetsadministratör användare (IT, information) Person som utnyttjar informatio

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2021-08/Terminologi%20inom%20informationssa%CC%88kerhetsomra%CC%8Adet%20%20LU%20-%20Rev%202.0%20210622.pdf - 2026-05-20

BESLUT 2021-12-16 Dnr STYR 2021/ 2717 LuNns UNIVERSITET Re ktor Revidering av handläggningsordning gällande u n iversitetsgemensam fi nans ieri ng av forskni n gs i nfrastruktu r vid Lunds universitet Bakgrund Universitetet avsätter ca tjugo miljoner kronor årligen till finansiering av lokal forskningsinfrastruktur. F orm och ftirutsättningar ftir detta universitetsgemensamma stödprogram - från ut

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-01/rektorsbeslut_handlaggningsordning_lok_infrastruktur_2021.pdf - 2026-05-20

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2023-11/Mall%20handlingsplan%20f%C3%B6r%20h%C3%A5llbar%20utveckling-fakultet-tillg_2023.docx - 2026-05-20

Riktlinjer för beskrivning av forskningsoutput i LUCRIS Riktlinjer för beskrivning av forskningsoutput i LUCRIS 0 Riktlinjer för beskrivning av forskningsoutput i LUCRIS LUB:s arbetsgrupp för forskningsoutput i LUCRIS (AGROL) Version 2.0 Inledning Detta dokument innehåller de lokala riktlinjerna för beskrivning av forskningsoutput i LUCRIS, vilket avser hur de olika fälten i registreringsformuläre

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-05/Riktlinjer_beskrivning_av_forskningsoutput_2.0.pdf - 2026-05-20