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Objectives To determine whether serum vascular endothelial growth factor (s-VEGF) levels and VEGF gene expression in tumor tissue predict survival of diffuse large B-cell lymphoma (DLBCL) patients treated with chemoimmunotherapy. Methods VEGF levels were measured in serum samples from 102 patients <65yrs with high-risk DLBCL using a quantitative sandwich enzyme immunoassay technique. Exon array da
Abstract Conclusion: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. Objectives: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. Method
Several investigations have revealed surprisingly high activities during the winter in vegetation and soil in temperate and subarctic areas. Plants have been found to photosynthesize even under snow cover and at temperatures below freezing, and decomposer microorganisms can function, at low rates, all year around. In temperate grasslands, the vegetation includes winter annual herbs as well as bryo
A search for new phenomena in t (t) over bar events with large missing transverse momentum in proton-proton collisions at a center-of-mass energy of 7 TeV is presented. The measurement is based on 1: 04 fb(-1) of data collected with the ATLAS detector at the LHC. Contributions to this final state may arise from a number of standard model extensions. The results are interpreted in terms of a model
Climate change is already contributing to the displacement of millions of people worldwide as extreme weather events become increasingly frequent and intense. Proposals for responding to the phenomenon of climate change-related displacement overwhelmingly rely on the state to act, with limited discussion of the potential to determine and develop the scope of protection through strategic litigation
Svensson F, Fredlund C, Svedin CG, Priebe G, Wadsby M. Adolescents selling sex: Exposure to abuse, mental health, self-harm behaviour and the need for help and support-a study of a Swedish national sample. Nord J Psychiatry 2013; 67: 81-88. Background: Selling sex is not uncommon among adolescents and we need to increase our knowledge of how this affects them. Aim: The aim of this study was to inv
The first appearance datum (FAD) of the cosmopolitan agnostoid trilobite Lotagnostus americanus is a widely used marker for defining the base of the uppermost stage of the Cambrian System. Detailed field study on the L. americanus-bearing interval of the Wa'ergang section, Hunan, China, reveals the FAD of L. americanus to be 29.65m above the base of the Shengjiawan Formation. This horizon is close
There is a need for improvement of the commonly used adenovirus vectors based on serotype 5. This study was performed on three adenovirus serotypes with a CAR-binding motif (Ad4p, Ad5p and Ad17p) and three non-CAR-binding serotypes (Ad11p, Ad16p and Ad21p). The capacity of these alternative adenovirus vector candidates to deliver DNA into low-passage glioma cell lines from seven different donors w
Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result of cleavage by a protease, and the latent form, which is also inactive, can arise due to a mutation
BACKGROUND: Eosinophils have a typical content of granule-bound, cytotoxic, cationic proteins which may, when released to the external milieu, play roles in diseases such as asthma and parasitic infestation. Therefore, we have investigated possible mechanisms by which their release is regulated in eosinophils. METHODS: The enzyme-linked immunosorbent assay (ELISA) was used to detect released eosin
Objective: To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories. Methods: Serum samples were derived from patients with histological and clinical diagnosis of WG (n = 60), rheumatoid arthritis (RA) (n = 30) and healthy controls (n = 30). Each of them was tested for the pre
Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. The study aimed to analyze if self-rated symptoms of depression are related to insulin resistance among middle-aged and older Swedish women with features of the metabolic syndrome and being at risk for type 2 diabetes mellitus. We analyzed data from 1047 Swedish
Popular Abstract in Swedish En populärvetenskaplig sammanfattning Det faktum att vårt minne förändra's med åldern är ett välkänt och väldokumenterat fenomen. Vilka faktorer som bidrar till denna förändring och hur de samverkar för att påverka vårt minne är däremot till stora delar forfarande ett mysterium. Minnesforskare delar vanligtvi's upp vårt minne i flera olika minnessystem. Dessa dela's upThe aim of this thesis was to examine the importance of environmental, non-cognitive, and person-based variables for memory performance in old adults. Study I was conducted in cooperation with the Gerontology Research Centre and the Department of Psychology in Lund. The investigation included 69 people with an age-range from 55-94 years and examined if certain personality factors could explain th
