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FLT3 is a critical prognostic marker in acute myeloid leukemia (AML) due to its high frequency of mutation. Primary mutations in FLT3 include point mutations or deletions in the tyrosine kinase domain (TKD) and internal tandem duplications (ITD) in the juxtamembrane (JM) region. These mutations lead to ligand-independent activation, disrupting the JM region and kinase domain interaction, resulting

We explore the challenges facing the current academic training of economists in small European countries such as Sweden. The monolithic focus on publishing in the top-five journals, which prioritizes methodological rigor over problem-driven research, is often a threat to social relevance and policy applicability. This limits pluralism, excludes many talented economists, and fails to prepare gradua

The Freedom Theatre is one of the most remarkable institutions in occupied Palestine, and indeed the world. Nestled in Jenin refugee camp in the West Bank, the theatre has faced attacks, threats, imprisonment of many functionaries, and the assassination of its co-founder. And yet the theatre has not only endured, it has grown, from a provisional hall with rented plastic chairs to one of Palestine'The Freedom Theatre is one of the most remarkable institutions in occupied Palestine, and indeed the world. Nestled in Jenin refugee camp in the West Bank, the theatre has faced attacks, threats, imprisonment of many functionaries, and the assassination of its co-founder. And yet the theatre has not only endured, it has grown, from a provisional hall with rented plastic chairs to one of Palestine'

This study investigates the excess mortality, both all-cause and due to suicide, among individuals with schizotypal disorder (SD) compared to the general population. Using individual-level data from the Swedish National Patient Register and the Cause of Death Register, we analyzed mortality in 998 patients diagnosed with SD from 2006 to 2017. Our primary outcomes were all-cause mortality and suici

Reflections on the need for Question Zero in AI-kommissionensFärdplan Sverige.

The background to this article is an interest in what categorisations such as ‘persons with or without disability’ create in terms of inequality and stigma, and how categorisations can support the implementation of Universal Design (UD). The article aims to show how a shift in categorisation can lead to a shift in the conceptualisation of UD, from “inclusive” to “nonclusive” design, i.e., to desig

In the dawning era of artificial intelligence (AI), health care stands to undergo a significant transformation with the increasing digitalization of patient data. Digital imaging, in particular, will serve as an important platform for AI to aid decision making and diagnostics. A growing number of studies demonstrate the potential of automatic pre-surgical skin tumor delineation, which could have t

Background: Blood typing is essential for safe transfusions and is performed serologically or genetically. Genotyping predominantly focuses on coding regions, but non-coding variants may affect gene regulation, as demonstrated in the ABO, FY and XG systems. To uncover regulatory loci, we expanded a recently developed bioinformatics pipeline for discovery of non-coding variants by including additio

Although ensuring that victimised children receive timely medical health assessments is among the key aims of Barnahus, this goal has proven difficult to achieve in Norway, the empirical case examined in this chapter. Few children are offered a medical examination, and most examinations that are performed primarily serve a role in the “penal track” of the Barnahus model. Based on data from two nat