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A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction. Synaptic activity increases Aβ secretion, potentially inhibiting synapses, but also decreases intraneuronal Aβ, protecting synapses. We now show that levels of secreted Aβ fall with time in culture in neurons of AD-transgenic mice, but not wild-type mice. Moreover, the ability

Modelling tools used in impact assessment procedures can be regarded as tools for communication between science and policy. In order to create an integrated system for modelling not only the scientific components have to be in place but also the science/policy interfaces in the assessment procedures have to be identified and their social dynamics understood.To make a system like SEAMLESS Integrate

In the field of second language acquisition (SLA) it is an important question, which role the native language assumes in the acquisition of another language. Studies have shown that there exists a native language influence on a phonological and lexical level. The situation in syntax is however different. Here a native language influence (transfer) is not self-evident.

Uppsatsen undersöker den skönlitterära läsupplevelsen i applikationen Iceberg Reader för Iphone. Vid uppsatsens tillkomst var läsapplikationer för Iphone och Ipad något nylanserat i Sverige, och få läsare hade erfarenhet av läsning via denna plattform. Med hjälp av två kvalitativa undersökningar – en enkät, där nio personer deltog, och en fokusgruppsundersökning, där fem av de nio var med – har vi

Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion of antibiotic treatment. The role of colonizing biofilm bacteria in this process is not fully clear. Here, live respiratory epithelial cells were ino

Repeated injury of the lung epithelium is proposed to be the main driver of idiopathic pulmonary fibrosis (IPF). However, available therapies do not specifically target the epithelium and human models of fibrotic epithelial damage with suitability for drug discovery are lacking. We developed a model of the aberrant epithelial reprogramming observed in IPF using alveolar organoids derived from huma

Cell-based therapies hold great promise in re-establishing organ function for many diseases, including untreatable lung diseases such as idiopathic pulmonary fibrosis (IPF). However, many hurdles still remain, in part due to our lack of knowledge about the disease-driving mechanisms that may affect the cellular niche and thereby possibly hinder the function of any transplanted cells by imposing th

As both public and private organizations are spending resources on fostering entrepreneurship, we have witnessed the emergence of an entrepreneurship industry. Using the entrepreneurship industry in Sweden as a case and example, this chapter provides an explorative analysis the emergence, manifestations and consequences of cultural ideals within this industry. The analysis reveals how the entrepre

En ideal bild av en aktör visar på självständighet och kontroll. För organisationer i det civila samhället är frågorna om beroende och oberoende ständigt brännande. Ett nytt krav på en ”effektrapport” väcker mycken tankemöda. Ska den idéburna verksamheten börja ”mäta en massa saker” i stället för att ”jobba, jobba!”?Kapitlet redovisar en studie som sträcker s

Amongst other factors, host behaviour critically determines the patterns with which blood parasites occur in wild host populations. In particular, migratory hosts that sequentially occupy distant sites within and across years are expected to show distinct patterns of blood parasitism depending on their population-specific schedules and whereabouts. Here, we monitored haemosporidian parasitism in t

Millimeter-wave cellular communication requires beamforming procedures that enable alignment of the transmitter and receiver beams as the user equipment (UE) moves. For efficient beam tracking it is advantageous to classify users according to their traffic and mobility patterns. Research to date has demonstrated efficient ways of machine learning based UE classification. Although different machine

The breakup of the L-chondrite parent body (LCPB) in the asteroid belt at 466 Ma ago is the largest asteroid breakup documented in Earth's geological record for the past ca. three billion years. Recovery of abundant macroscopic fossil L chondrites in mid-Ordovician marine sediments as well as reconstructions of the flux of micrometeoritic chrome spinel through the ages have given much new informat

Summary: In this prospective study in Swedish elderly men, PAD based on an ABI < 0.9 was associated with an increased risk of hip fracture, independent of age and hip BMD. However, after further adjustments for comorbidity, medications, physical function, and socioeconomic factors, the association diminished and was no longer statistically significant. Introduction: To examine if peripheral arteri

Översiktlig artikel om hur spanska sjukan 1918 drabbade Lunds universitet och särskilt dess studenter samt om hur vissa professorer i medicin förhöll sig till den nya smittan.