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Acquired chromosome abnormalities in tumours often reflect pathogenetic events at the gene level. Multicolour fluorescence in situ hybridisation (FISH) with single-copy probes offers extensive possibilities to characterise chromosome breakpoints in relation to the physical map of the human genome. This approach is based on the construction of comprehensive EST- based maps, combinatorial labelling
The Wilms tumor gene (WT1) encodes a zinc-finger containing transcription factor present in primitive hematopoietic progenitor cells. WT1 is also highly expressed in most cases of acute myeloid leukemia. Moreover, WT1 can interfere with induced differentiation of leukemic cell lines. These data suggest a function of WT1 in the maintenance of a primitive phenotype and a role in leukemogenesis by in
The process of change has been considered within many areas of contemporary thinking. Consequently, many aspects of change have been explored through different theoretical angles. Using insights from 'translation' theory, this article considers critical factors that affect cross-sectoral networking process for SD-a popular form of collaboration. The empirical data for this study comes from the inv
Popular Abstract in English Labour is said to be obstructed when the baby’s presenting part fails to descend through the birth canal despite strong uterine contractions. Obstructed labour is one of the major causes of maternal and neonatal mortality and morbidity in low-income countries. It is mostly caused by disproportion between the baby’s head and mother’s pelvis but also abnormal presentationLabour is said to be obstructed when the presenting part fails to descend through the birth canal despite strong uterine contractions. The condition is mostly prevalent in low-income countries where the main causes are cephalopelvic disproportion and malpresentation. The overall aim of this thesis was to investigate the individual, community and health system factors associated with obstructed lab
Informetric/bibliometric analyses have to a large extent been relying on an assumption that research is essentially cumulative in its nature, which is not the least visible in the rational for using citation analyses to assess quality of research. However, when reviewing both the theoretical literature on how research is organized and studies analyzing the structures of research fields through inf
Kerstin Thorvall (1925–2010) is a Swedish author of books for children and young adults, as well as books for adults. In 1965, she wrote the article “Do all authors of children's books live in Tomtebolandet?” (“Bor alla barnboksförfattare i Tomtebolandet”, Expressen 1965) in which she claims that gender roles in Swedish children's literature, are depicted in an old and stereotypical fashion. She a
Background: Integration of second-generation (2G) bioethanol production with existing first-generation (1G) production may facilitate commercial production of ethanol from cellulosic material. Since 2G hydrolysates have a low sugar concentration and 1G streams often have to be diluted prior to fermentation, mixing of streams is beneficial. Improved ethanol concentrations in the 2G production proce
My purpose in this article is to make a contribution to what the legal philosopher H.L.A. Hart (1907-1992) has to say about providing a sociological understanding of law and to apply Hart's theory in relation to a specific area of law. The specific legal area consists of the violation compensation that victims of crime can obtain from the Crime Victim Compensation and Support Authority in Sweden.
The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observ
The variations in functional capacity, life quality and health increase as people grow older. Most likely, this is the result of a lifelong process in which both "wear-and-tear" and constructive development play a major role. Life experiences all the way from daily hazards to burdensome life events, to long-term exposure, to stress and strain might wear out the body. Life experiences of self-fulfi
The Euro50 is a proposed 50m extremely large telescope for optical and infrared wavelengths. To study and predict the performance of the complete telescope system, an integrated model combining the structural model of the telescope, optics models, the control systems and the adaptive optics has been established. Wind and atmospheric disturbances are also included in the model. The model is written
It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated. In this study, we examine the distribution, structure and putative role of the two major hyaluronan-binding proteoglycans, PG-M/versicans and aggrecan, during the course of avian NC development. PG-M/versicans
We sought to evaluate the experiences and knowledge of health care providers in Sweden regarding female genital cutting (FGC) as a health issue. Questionnaires (n = 2,707) were sent to providers in four major cities in Sweden and evaluated by means of descriptive statistics. Twenty-eight percent (n = 769/2,707) responded, of whom 60% had seen such patients. Seven providers, including 2 pediatricia
A cutting-edge assessment of policy options for future global climate governance, written by a team of leading experts from the European Union and developing countries. Global climate governance is at a crossroads. The 1997 Kyoto Protocol was merely a first step, and its core commitments expire in 2012. This book addresses three questions which will be central to any new climate agreement. What is
This study investigated if clothing material with reflective properties has an effect on heat gain in pilot, specifically, under solar radiation. Two materials, conventional pilot suit material (Old) and material coated with coldblack® (New, Schoeller Technologies AG, Switzerland) were tested over variety of underwear layers and in a box simulating cockpit. A hot plate was used to measure textile
Abstract not available
