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Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance

Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind

Asylrätten är en het politisk fråga i och med den europeiska flyktingkrisen. Denna uppsats är ett försök att reda ut vilka folkrättsliga skyldigheter och EU-rättsliga som åligger Europeiska stater, och i synnerhet Sverige, på asylrättens område. Fyndet är att en allmän rätt till asyl inte existerar, men i praktiken finns något som kan liknas vid detta i och med förbudet mot att förvisa en flykting

Using theory of elasticity it is not possible to describe exactly how a statically indeterminate structure collapses. Theory of elasticity is often combined with an assumption of breakage at a certain level of stress, this meaning that a structure will break as soon as this level of stress is reached in the most heavily loaded section. A plastic hinge will occur followed by a changed distribution

Soft regionalism och regionala identiteter i Storbritannien har sällan blivit utforskade utöver nationella debatter avseende Skottland, England, Wales och Cornwall. Dessutom har även många senare regionala studier i England försummats helt. Denna studie har sin bakgrund i den pågående debatten om decentrialisering (devolution) och skapandet av nya regionala myndigheter och urbaner-regioner i StorbSoft regionalism and regional identities in Great Britain has seldom been explored beyond the national debates of Scotland, Wales, and Cornwall. Many recent local studies in England have, too, been neglected. This study is set against the backdrop of the ongoing debates around devolution within the United Kingdom and the creation of new regional authorities and city-regions. This thesis investigat

In this thesis we consider a general approach to modeling dependence in extreme values of exchange rates by using copulas. As specific examples the following pairs of currencies are analyzed: Swedish krona to U.S. dollar (SEK/USD), Swedish krona to Euro (SEK/EUR), Swedish krona to British pound (SEK/GBP), Swedish krona to Japanese Yen (SEK/JPY), Swedish krona to Danish krone (SEK/DKK) and Swedish

Introduction: In this thesis, I critically examine three discourses, prevalent within the 'field' of sexual violence in migration. Methodology: Taking a poststructuralist approach, I deconstruct the beforementioned discourses in a threefold analysis. Results: I find, that the binary gender system is still dominating, and that certain ideas about 'men' and 'women', their bod

Pesticides or plant protection products (PPP) protect plants from harmful organisms and prevent the spread of invasive species. However, their use is not without problems, as pesticides can have harmful effects on the environment. One of these effects is reduced biodiversity, as pesticides often affect non-target organisms and change water and soil composition. Reduced diversity through the cleari

Products made from pulp are a part of everyday life. With end products like coffee filters, food packaging and tissue paper. These products are the result of wood being processed in pulp mills to produce the pulp from which the forementioned paper products are produced. The modern pulp and paper industry is energy intense and on a global perspective a large emitter of greenhouse gasses, accounting

Plankorsningar, där väg och järnväg möts i en punkt, utgör en riskfylld del av transportsystemet. Olyckorna vid plankorsningar har lett till allvarliga konsekvenser i Sverige. Där Sveriges långsiktiga mål (Nollvisionen) syftar på att ingen ska dö eller skadas allvarligt i trafiken, vilket omfattar att öka säkerheten vid plankorsningar för att. Syftet med examensarbete har varit att undersöka säker

Finding and maintaining adequate housing is an increasingly serious struggle for many. To what extent the right to housing in international law offers a way out of this struggle is a crucial question that requires careful thinking. This chapter offers a perspective for answering this question by focusing on a particular group: migrants and refugees. To do so, it examines the dynamics of how the ri

Religionsfrihet är en grundläggande mänsklig rättighet. Artikel 9 i Europakonventionen reglerar religionsfriheten och dess begränsningar. Konventionen är inkorporerad i svensk lagstiftning och ska således tillämpas i Sverige. Med anledning av det så kallade handskakningsmålet ställs religionsfriheten i förhållande till arbetet mot ett könsjämlikt arbetsliv. Frågan väcks och diskuteras huruvida relFreedom of religion is a fundamental human right. Article 9 of the European Convention regulates religious freedom and its limits. The Convention is incorporated in Swedish law and has to be applied in Sweden. On account of the so-called handshake-case, the freedom of religion is put in relation to work towards a gender-balanced working life. The question is raised and discussed whether freedom of