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Introduction: Evidence for gut–kidney interactions in early kidney disease is limited, particularly in community-dwelling adults with largely preserved kidney function. Here, we quantified links between gut microbiota and estimated glomerular filtration rate (eGFR) in two population-based Swedish cohorts. Methods: Deep shotgun metagenomics profiled fecal samples from 9788 adults in the Swedish CAr
Rapid urban growth is making cities hotter, a trend further exacerbated by climate change. Urban green spaces (UGS) are commonly used as nature-based solutions to reduce heat, but there are gaps in understanding how cooling effects vary across climate zones. Using satellite data from 2021 to 2024, we examined urban heat and UGS patterns during the hot season across four Ethiopian cities with diffe
OBJECTIVE: To evaluate the association between metformin use and incident osteoarthritis (OA) in people with diabetes and the impact of dosing. DESIGN: Nested case-control study within a cohort of >1.4 million individuals from Sweden. PARTICIPANTS: Participants were aged 35-80 years in 2005, without diabetes or OA. We identified persons with incident diabetes between 2006 and 2016 and excluded tho
Background: L-DOPA-induced dyskinesia is attributed to opposite activity changes mediated by D1 and D2 dopamine receptors in the two striatal output pathways. Whereas the causal role of direct-pathway D1 receptors is well established, the specific involvement of indirect-pathway D2 receptors in dopaminergic dyskinesias has remained elusive. Objectives: We used conditional knockout approaches in mi
Background: The variable clinical outcomes of mesenchymal stromal cell (MSC)-based therapy in acute respiratory distress syndrome (ARDS) are attributed to a variety of factors, including host microenvironmental factors. Interleukin-1β (IL-1β) has been linked to the development and progression of ARDS, and we have previously found that IL-1β could be used to predict MSC activation in vitro. However
OBJECTIVES: Early diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) MRI parameters, including cerebral blood volume (CBV), cerebra
Due to ongoing climate change, methane (CH4) emissions from vegetated wetlands are projected to increase during the 21st century, challenging climate mitigation efforts aimed at limiting global warming. However, despite reports of rising emission trends, a comprehensive evaluation and attribution of recent changes remains limited. Here we assessed global wetland CH4 emissions from 2000-2020 based
On-site hydrogen gas production from hydrogen-rich liquids offers a clean alternative to fossil fuels for combustion that is readily implemented in existing energy infrastructure. A heterogenized (POCOP)-Ir pincer catalyst can be operated at higher temperatures for higher turnover frequency, but the reaction pathway of the reported complex has not been well understood. Here, we report intermediary
Anthropogenic land-use change (LUC) substantially impacts climate dynamics, primarily through modifications in the surface biogeophysical (BGP) and biogeochemical (BGC) fluxes, which alter the exchange of energy, water, and carbon with the atmosphere. Despite the established significance of both the BGP and BGC effects, their relative contribution to climate change remains poorly quantified. In th
Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural
After the clinical implementation of amyloid-β-targeting therapies for people with cognitive impairment due to Alzheimer's disease (AD), there is an urgent need to efficiently identify this patient population in primary care. Therefore, we created a brief and self-administered digital cognitive test battery (BioCog). Based on its sub-scores, a logistic regression model was developed in a secondary
BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14
Animals live in diverse environments and have evolved to cope with environmental challenges in different ways. How such adaptations shape overall brain morphology is still unclear. Here, we test how two behavioural adaptations – circadian activity pattern and migratory behaviour – are reflected in the brains of moths and butterflies (Lepidoptera). We predicted that circadian activity pattern affec
OBJECTIVES: Asphalt is frequently used as road pavement and consists of bitumen as a binder, and fillers. Bitumen consists of a complex mixture of hydrocarbons, where a minor component is polycyclic aromatic hydrocarbons (PAHs). Many PAHs are classified as carcinogenic to humans. Bitumen fumes from road paving have been classified as possibly carcinogenic. Paving and milling are open processes gen
Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t
Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus
Brevmall Socia lhögskolan Allmän studieplan för utbildning på forskarnivå till doktorsexamen i social arbete Studieplanen är fastställd av samhällsvetenskapliga fakultetsstyrelsen 2013-03-21. 1. Ämnesbeskrivning Forskning i socialt arbete handlar huvudsakligen om sociala problem, deras uppkomst, orsaker och lösningar; utsatta gruppers och individers villkor och levnadsförhållanden; analyser av väl
https://www.soch.lu.se/internt/sites/soch.lu.se.internt/files/studieplan-forskarutbildning.pdf - 2026-07-18
LOCAL FOOD SYSTEMS & SUSTAINABLE DEVELOPMENT: ANALYZING A REGIME CHANGE IN KANE COUNTY, ILLINOIS, USA, THROUGH A TRANSITION THEORY PERSPECTIVE Author TYLER LELAND STROM Email: tyler.strom@gmail.com For the degree of MASTER OF SCIENCE Thesis Supervisor Ann Åkerman Email: ann.akerman@lucsus.lu.se Lund University Center for Sustainability Studies, LUCSUS Geocentrum 1, Sölvegatan 10 P.O. Box 170, SE-2
https://www.lumes.lu.se/sites/lumes.lu.se/files/strom_tyler_thesis_2010.pdf - 2026-07-18
Vård- och omsorgsförv altningen Avdelningen för kvalitet och utveckling Lisa Ekstam Forskare lisa.ekstam@helsingborg.se 2019-03-11 RAPPORT Kontaktcenter 042-10 50 00 · kontaktcenter@helsingborg.se Postadress · Vård- och omsorgsförvaltningen 251 89 Helsingborg v ardochomsorg.helsingborg.se Aktiviteter och gemenskap för ökad hälsa och välbefinnande -Rapport om ensamhet och aktiviteter på vårdboenden
https://www.case.lu.se/sites/case.lu.se/files/lisa_ekstam_slutrapport_om_ensamhet_och_aktiviteter_pa_vardboenden.pdf - 2026-07-18
1 Utvärdering av forskarutbildningen i socialt arbete vid Lunds universitet 2019 Undertecknande sakkunniggrupp vill härmed avlägga följande utlåtande gällande utvärdering av forskarutbildningen i socialt arbete vid Lunds universitet. Sakkunniggruppen har bestått av: Peter Dellgran, professor i socialt arbete vid Göteborgs universitet (ordförande) Marjaana Seppänen, professor i socialt arbete vid H
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/sakkunnigutlatande_utvfoutbsocarbfinal.pdf - 2026-07-18
