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Alzheimer’s disease (AD) is the most common neurodegenerative disease. Most cases of AD are considered idiopathic and likely due to a combination of genetic, environmental, and lifestyle-related risk factors. Despite occurring decades before the typical age of an AD diagnosis, early-life stress (ELS) has been suggested to have long-lasting effects that may contribute to AD risk and pathogenesis. S
The nexus between the environment, natural resources and (armed) violence has been researched since the end of the nineties, however major theoretical and empirical gaps still exists in research on the precise role of nature or the natural environment during post-conflict and/or peacebuilding, particularly in relation to those countries that have undergone internal armed conflict.This paper presen
G protein-coupled receptor 30 (GPR30) is a membrane receptor reported to bind 17b-estradiol (E2) and mediate rapid nongenomic estrogen responses, hence also named G protein-coupled estrogen receptor. G-1 is a proposed GPR30-specific agonist that has been used to implicate the receptor in several pathophysiological events. However, controversy surrounds the role of GPR30 in G-1 and E2 responses. We
Nonlinear responses to externally forced climate change are known to dampen or amplify the local climate impact due to complex cross-compartmental feedback loops in the Earth system. These feedbacks are less well represented in the traditional stand-alone atmosphere and ocean models on which many of today's regional climate assessments rely (e.g., EURO-CORDEX, NOSCCA and BACC II). This has promote
The Arctic is warming rapidly, especially in winter, which is causing large-scale reductions in snow cover. Snow is one of the main controls on soil thermodynamics, and changes in its thickness and extent affect both permafrost thaw and soil biogeochemistry. Since soil respiration during the cold season potentially offsets carbon uptake during the growing season, it is essential to achieve a reali
The use of participatory action research in media studies is under development and has the last years become notable as a new way of exploring changes that has taken place on the media market the last decades. Media corporations in Sweden continue shutting down local editorial offices and centralize local news reporting to the head editorials. An absence of local reporting in several rural areas iThe use of participatory action research in media studies is under development and has the last years become notable as a new way of exploring changes that has taken place on the media market the last decades. Media corporations in Sweden continue shutting down local editorial offices and centralize local news reporting to the head editorials. An absence of local reporting in several rural areas i
Cooperativity is an efficient way for nature to regulate complex processes, allowing for control over a narrower range of concentrations compared to noncooperative phenomena. Here, we investigate the cooperative binding of α-Synuclein to lipid membranes under different conditions, aiming to uncover the underlying molecular driving forces. We interrogate the role of electrostatic interactions by ra
OBJECTIVE: Diabetes significantly increases the risk for atherosclerotic complications, including coronary artery disease (CAD). Previous studies have suggested that adult-onset diabetes can be classified into five different clinical subtypes, including moderate obesity-related diabetes (MOD). The aim of this study was to investigate the genetic associations between the five diabetes subtypes and
Skin wounds remain a clinical challenge, especially for burns and chronic wounds, and existing therapies seldom re-engage the rapid, scar-sparing repair programs observed in nature. Planarians are super-regenerators capable of rebuilding the entire organism from small fragments, and their extracellular vesicles might encode potent prorepair cues. But whether planarian-derived extracellular vesicle
BACKGROUND: In May 2023, the World Health Organization declared COVID-19 no longer a public health emergency. Despite successful vaccination campaigns, vaccines provide limited protection against transmission. Since general testing has been abandoned in most countries, alternative population surveillance methods to assess SARS-CoV-2 exposure are needed.METHODS: N-antigen is a protein of the SARS-C
Background: Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort. Methods: This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50–64 years, n = 8,957). Sodium
Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenom
CONTEXT: Statin use is associated with increased risk of type 2 diabetes and mild hyperglycemia. The underlying mechanisms are not well studied and the effect of statin treatment on GLP-1 secretion or production are unknown.OBJECTIVE: To assess the effects of rosuvastatin on GLP-1 secretion and production.METHODS: We performed association studies in the Malmö Diet and Cancer study cardiovascular c
Huntington's disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in aging humans. To address this, we generated induced neurons (iNs) through direct reprogramming of human skin fibroblasts, which retain age-dependent epigenetic charact
AIMS: Patients awaiting orthotopic heart transplantation (OHT) can be bridged utilizing a left ventricular assist device (LVAD) that reduces left ventricular filling pressures, decreases pulmonary artery wedge pressure, and maintains adequate cardiac output. This study set out to examine the poorly investigated area of if and how pre-treatment with LVAD impacts right ventricular (RV) function foll
We compared vaccine effectiveness (VE) against severe COVID-19 during calendar periods from December 2021 to March 2022 when Omicron BA.1 and BA.2, respectively, were the dominating virus variants in Scania county, Sweden. We used continuous density case-control sampling matched for sex and age, and with further adjustment for differences in comorbidities and prior infection. VE remained relativel
Based on the Baltic Earth Assessment Reports of this thematic issue in Earth System Dynamics and recent peer-reviewed literature, current knowledge of the effects of global warming on past and future changes in climate of the Baltic Sea region is summarised and assessed. The study is an update of the Second Assessment of Climate Change (BACC II) published in 2015 and focuses on the atmosphere, lan
