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Lakatos's challenge? : Auxiliary hypotheses and non-monotonous inference

Gerhard Schurz [2001, Journal for General Philosophy of Science, 32, 65-107] has proposed to reconstruct auxiliary hypothesis addition, e.g., postulation of Neptune to immunize Newtonian mechanics, with concepts from non-monotonous inference to avoid the retention of false predictions that are among the consequence-set of the deductive model. However, the non-monotonous reconstruction retains the

Clinical studies of extended-half-life recombinant FVIII products for prophylaxis in adults and children : A critical review from the physician's perspective

This review compares the methodology of published clinical studies investigating the extended-half-life (EHL) factor VIII (FVIII) products, rFVIIIFc (efmoroctocog alfa, Elocta®/Eloctate®), BAY 94-9027 (damoctocog alfa pegol, Jivi®), BAX 855 (rurioctocog alfa pegol, Adynovate®) and N8-GP (turoctocog alfa pegol, Esperoct®) including the phase 2/3 studies, A-LONG (NCT01181128), PROTECT VIII (NCT01580

Interim Report on Gribshunden (1495) Excavations: 2019–2021

We present an interim archaeological report on the ship- wreck of the Danish-Norwegian flagship Gribshunden. Built in 1485, extensively employed by King Hans as his floating castle, and ultimately lost in June 1495 en route to Kalmar, the ship carried people and material selected to further the political goal of re-unifying the Nordic region. Three field campaigns led by Lund University and Blekin

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Countercurrent distribution of lymphocytes from human peripheral blood in an aqueous two-phase system. : II. Separation into subsets of lymphocytes with distinctive functions

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions.

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Prevention and Management of Bleeding Episodes in Children with Hemophilia

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Induction of platelet thrombi by bacteria and antibodies.

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Lunds-universitets-magasin-10-2008

lum_2008_10 LUM Lunds universitets magasin | Nr 10 | 2008 stråLande behandLing Organdonatorer lämnas i sticket Bebisar lär oss hur vi tolkar omvärlden 2 LUM nr 10 | 2008 jordbrUk Med förhinder LUM nr 10 | 2008 3 Med besök av två internationel­ la toppforskare och ett välbesökt seminarium på Kulturen firades avstampet för ett nytt forskar sam­ arbete vid LU. Det inriktar sig på jordbruksutveckling

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-10-2008.pdf - 2026-04-25

Nanoscience colloquium 2018 08 26 zhong lin lores

Nanoscience_Colloquium_2018_08_26_Zhong_Lin_lores For full program of NanoScience Colloquia see: http://www.nano.lu.se/news-and-events/nanoscience-colloquia NNAANNOOSSCCIIEENNCCEE CCOOLLLLOOQQUUIIUUMM Prof. Zhong Lin Wang Monday August 26th, 2019 at 10:15, in k-space, Fysicum Maxwell’s displacement current governed triboelectric nanogenerator for self-powered systems & blue energy Hightower Chair

https://www.nano.lu.se/sites/nano.lu.se/files/nanoscience_colloquium_2018_08_26_zhong_lin_lores.pdf - 2026-04-25

Klimatsakrat skane 115mb

_Inlaga_A4_0112_RIP.indd Klimatsäkrat Skåne CEC RappoRt · 02 | 2015 | Lunds univERsitEt KLIMATSÄKRAT SKÅNE Lunds universitet 2015 Rapporten har finansierats i samverkan mellan Klimatsamverkan Skåne och Centrum för miljö- och klimatforskning. Den ingår som nr 2 i serien CEC Rapporter. Projektledare: Marianne Hall Sök-/nyckelord: klimat, klimatförändring, anpassning, utsläppsminskning, hållbar utvec

https://www.cec.lu.se/sites/cec.lu.se/files/klimatsakrat_skane_115mb.pdf - 2026-04-25