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Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to
Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i
In this paper the PreAmplifier ShAper (PASA) for the Time Projection Chamber (TPC) of the ALICE experiment at LHC is presented. The ALICE TPC PASA is an ASIC that integrates 16 identical channels, each consisting of Charge Sensitive Amplifiers (CSA) followed by a Pole-Zero network, self-adaptive bias network, two second-order bridged-T filters, two non-inverting level shifters and a start-up circu
The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib
In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl
Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel
The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit
Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in
Hållbarhetsplan för Lunds universitet 2020–2026 Hållbarhetsplan för Lunds universitet 2020–2026 REVIDERAD 2025 | BESLUTAD AV REKTOR 2025-06-19 DNR STYR 2025/1078 | LUNDS UNIVERSITET FO T O : H Å K A N R Ö JD E R , K E N N E T R U O N A , JO H A N P E R S S O N ................................................................................... .......................................................
Brevmall Postadress Box 117, 221 00 Lund Besöksadress Paradisgatan 5C Telefon 046-222 77 71, 046-222 00 00 E-post anneli.wiklander@fs.lu.se Rektor Föreskrifter rörande hantering av ekonomiska intresse- konflikter relaterade till viss amerikansk forskningsfinansiering Bakgrund I samband med ansökan om forskningsbidrag och för att kunna ta emot forskningsmedel från USA:s statliga finansiärer, särski
The aim of this study is to investigate what factors shaped the decision making process regarding the Swedish military contribution to UN mission in Liberia 2003. At the time Sweden already had an on-going mission in the Democratic Republic of Congo and the Swedish Armed Forces was in the midst of a thoroughgoing reform of its military forces as well as its core objectives. The focus of the study
Agreements with SKR (Swedish Association of Local Authorities and Regions) have emerged as a significant steering instrument for the Ministry of Health and Social Affairs (MHSA). The agreements define activities for the Local Authorities to carry out and nearly always include earmarked grants. No study has yet explained why agreements are utilized as a steering instrument. Therefore, this study se
Musikhögskolan i Malmö LÄSÅRSÖVERSIKT 2026/2027 Musikerutbildningarna Musiklärarutbildningarna V Datum SYMF SÅNG PIAN GITA BLFL CEMB KOMP KY Kantor JAIN FOVÄ INST ML 1 ML 2 ML 3 ML 4 ML 5 KPU 2 KUPE 1 KUPE 2 33-34 10/8-23/8 35 24/8-30/8 36 31/8–6/9 Projekt Projekt 37 7/9–13/9 Projekt Projekt 38 14/9–20/9 39 21/9–27/9 40 28/9–4/10 Orkesterprojekt EAM VFU VFU 41 5/10–11/10 VFU VFU 42 12/10–18/10 Pro
https://www.mhm.lu.se/sites/mhm.lu.se/files/2026-04/La%CC%88sa%CC%8Arso%CC%88versikt%20MHM%2026-27.pdf - 2026-04-26
MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion
