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Mitochondrial creatine kinase (Mi-CK) isoenzymes, in contrast to cytosolic CKs, form octameric molecules composed of four stable dimers. Octamers and dimers are interconvertible. Removal of the N-terminal pentapeptide of chicken cardiac Mi-CK (Mib-CK) by limited proteolysis drastically destabilized the octamer. The role of the charged amino acids within the N-terminal heptapeptide was studied in d
Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while outperforming established tags like the HA-, FLAG®- or myc-tag. The ALFA-tag forms a small and stable α-helix that is func
Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To address this unmet need, novel pharmacological targets must be identified for clinical inter
A university student in China today might find himself or herself taking a “golden course” that blends practical and academic training. The student earns degree credit while gaining direct exposure to industry. The course might even be sponsored by Alibaba, the online retail giant, or another large firm.
Recentmonths have seen intensified global calls for an intellectual propertywaiver of COVID-19 related vaccines, treatments and related products.Where one side of the debate elevates Intellectual Property Rights as on obstacle to affordable and expeditious global access to vaccines and treatments, the other side of the debate points to the existing TRIPS flexibilities such as compulsory licensing,
In the 1820s and 1830s, British industry faced a choice between two energy sources to fuel its expansion: water and coal. A series of water reservoir schemes were proposed to scale up the power capacity of rivers in the central manufacturing districts, but the schemes with the largest potentials were never realized. Instead, the industry veered toward steam power, fatefully linking self-sustaining
Residential energy consumption is a consequence of household members’ activities in their homes. Analysing and understanding energy consumption in households therefore needs to start from household activities and everyday life. From household members’ time diaries, we can analyse and learn about when, where and what energy-related activities occur in the household, involving what household members
The bio-economy represents a significant shift in socio-economic, agricultural, energy and technical systems. The concept of the bio-economy – also called the bio-based economy or the knowledge-based bio-economy in Europe – can be understood as an economy where the basic building blocks for materials, chemicals and energy are derived from renewable biological resources, such as plant and animal so
Klädföretag säljer alla ”samma” produkt till sina konsumenter. Produkten är kläder med ett visst mode. För att kunna bli ett framgångsrikt företag är marknadsföring en viktig del, något som allt fler företag har blivit medvetna om. Med bakgrund av att allt fler företag vill synas på marknaden för att attrahera konsumenterna samt skapa en märkeskännedom hos dem, har vikten av differentierad reklam
