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Imaging of gynecological disease (3): clinical and ultrasound characteristics of granulosa cell tumors of the ovary

Objectives To describe the clinical and ultrasound characteristics of granulosa cell tumors (GCTs) of the ovary, and to define the ultrasound appearance of GCTs based on pattern recognition. Methods Databases of four gynecological ultrasound centers were searched to identify patients with histologically proven GCTs who had undergone a standard preoperative ultrasound examination. Results A total o

Manual correction of semi-automatic three-dimensional echocardiography is needed for right ventricular assessment in adults; validation with cardiac magnetic resonance

Background: Three-dimensional echocardiography (3DE) and semi-automatic right ventricular delineation has been proposed as an appropriate method for right ventricle (RV) evaluation. We aimed to examine how manual correction of semi-automatic delineation influences the accuracy of 3DE for RV volumes and function in a clinical adult setting using cardiac magnetic resonance (CMR) as the reference met

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

Background: Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM). However, it is still a daunting task to prioritize single nucleotide polymorphisms (SNPs) from GWAS for further replication in different population. Several recent studies have shown that genetic var

Asthma incidence in children growing up close to traffic: a registry-based birth cohort

Background: Recent reviews conclude an association between traffic-related pollution and incidence of asthma in children, but not all studies agree. Studies have almost exclusively relied on parental-reported symptoms or parental-reported diagnoses of asthma and wheeze. Our aim was to investigate if traffic exposure is associated with higher incidence of early onset asthma, using registry-based ou

Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention

Background: The objective was to investigate in a group of obese subjects the course in skeletal muscle phospholipid (SMPL) fatty acids (FA) during a 24-weeks weight maintenance program, which was preceded by a successful very low calorie dietary intervention (VLCD). Special focus was addressed to SMPL omega-3 FA, which is a lipid entity that influences insulin action. Methods: Nine obese subjects

Fermi Large Area Telescope and Multi-Wavelength Observations of the Flaring Activity of Pks 1510-089 between 2008 September and 2009 June

We report on the multi-wavelength observations of PKS 1510-089 (a flat spectrum radio quasar (FSRQ) at z = 0.361) during its high activity period between 2008 September and 2009 June. During this 11 month period, the source was characterized by a complex variability at optical, UV, and gamma-ray bands, on timescales down to 6-12 hr. The brightest gamma-ray isotropic luminosity, recorded on 2009 Ma

Collagenase treatment of Dupuytren's contracture using a modified injection method

Background and purpose - Treatment of Dupuytren's contracture (DC) with collagenase Clostridium histolyticum (CCH) consists of injection followed by finger manipulation. We used a modified method, injecting a higher dose than recommended on the label into several parts of the cord, which allows treatment of multiple joint contractures in 1 session and may increase efficacy. We studied the occurren

Mortality Among Men with Locally Advanced Prostate Cancer Managed with Noncurative Intent: A Nationwide Study in PCBaSe Sweden

Background: There are limited prognostic data for locally advanced prostate cancer PCa to guide in the choice of treatment. Objective: To assess mortality in different prognostic categories among men with locally advanced PCa managed with noncurative intent. Design, setting, and participants: We conducted a register-based nationwide cohort study within the Prostate Cancer DataBase Sweden. The enti

Separating Movement and Gravity Components in an Acceleration Signal and Implications for the Assessment of Human Daily Physical Activity

Introduction: Human body acceleration is often used as an indicator of daily physical activity in epidemiological research. Raw acceleration signals contain three basic components: movement, gravity, and noise. Separation of these becomes increasingly difficult during rotational movements. We aimed to evaluate five different methods (metrics) of processing acceleration signals on their ability to

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Ulnar head replacement or head resection in patients with distal radioulnar arthritis: a prospective cohort study of clinical and patient-reported outcomes up to 2 years after surgery

Background and purpose — Traditional surgery forarthritis of the distal radioulnar joint (DRUJ), which typicallyinvolves resecting the ulnar head, is being increasingly challengedby newer techniques, such as prosthetic ulnar headreplacement. The aim of our prospective cohort study was toinvestigate the clinical and patient-reported functional results,up to 2 years postoperatively, among patients w

Impact of COVID-19 after lung transplantation : A retrospective multicenter comparison of clinical outcomes in Denmark and Sweden

Background: The coronavirus disease-2019 (COVID-19) pandemic posed pronounced challenges in the care of lung transplant (LTx) recipients. Global variations in containment strategies and the introduction of messenger ribonucleic acid (mRNA) vaccines have sparked extensive debate in both scientific and public arenas. Methods: This retrospective study compared outcomes among LTx recipients in Denmark

Analyses of 1236 genotyped primary ciliary dyskinesia individuals identify regional clusters of distinct DNA variants and significant genotype–phenotype correlations

Background Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient ciliary airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship to diagnostic findings and clinical phenotypes. Methods Genetic variants and clinical findings (a

High-fat and low-fat fermented milk and cheese intake, proteomic signatures, and risk of all-cause and cause-specific mortality

PURPOSE: This study aimed to examine the associations between the intake of high- and low-fat fermented dairy (cheese and fermented milk), their proteomic profiles, and mortality risk.METHODS: This cohort study included 25,187 participants (mean age 57.7 years, 60.9% females). Fermented dairy intake was assessed by a modified diet history method. In a random subset of this cohort (n = 4359), we co

Structural analysis of X-flo measure system

This thesis is done in cooperation with Dresser Wayne AB in Malmö and the objective has been to investigate if it is possible to use the X-flo meter, see Figure 1, in an LPG-dispencer. An increased pressure is used in the LPG-system, which involves a higher risk of leaking and strength problems. During the development consideration has been taken to a new outlet, though other couplings are used in

Framtagning av model, för små frö till precisionssåmaskin

This thesis project was to develop a module for a forest precision seeder. The project is made at BCC AB. BCC is a worldwide supplier of forest seed centre and containerized nursery equipment. BCC develops, designs, produces and sales machines for forest seed handling. BCC s existing precision seeder can not handle seed that are tinier than 1 mm in diameter. With a growing market in countries with

Svenska Isaf-soldater i Afghanistan - en kvalitativ studie om upplevelser och känslor i samband med utlandstjänstgöring

Studiens syfte var att med en explorativ ansats undersöka och beskriva svenska afghanistansoldaters upplevelser och känslor kopplat till sin utlandstjänstgöring och att få en bredare bild med olika aspekter av hur detta upplevs av soldaterna själva. Syftet var även att låta soldaterna ge synpunkter på Försvarsmaktens rutiner i form av bl.a. förberedelser, akut stöd på plats och uppföljning. DessutThe purpose of the study was to use an explorative approach to examine and describe Swedish Afghanistan veterans’ experiences and emotions in connection with their service abroad, and to create a broader picture with different aspects of how this is experienced by the veterans themselves. The purpose was also to let the veterans share their view of the Swedish Department of Defense’s routines incl

Total Cost of Purchasing at Duni AB: Development of a Cost Model

BAKGRUND På grund av att företag idag har möjlighet att konkurrera globalt genom att flytta produktionen utomlands och att säkra leveranser ifrån alla världens hörn har också inköpsfunktionens roll förändrats. För att nå företagets uppsatta mål är det viktigt att ha en välfungerande inköpsfunktion som jobbar effektivt. Inköpsfunktionen bör inte enbart fokusera på att uppnå det billigaste möjliga iBACKGROUND Through global competition with possibilities for companies to set up production and to secure supply from all over the world the role of purchasing has increased within businesses. In order to achieve business results, a well-working purchasing department plays an important part. To contribute, the purchasing function should not only focus on getting the cheapest price possible, but to