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Aims: To investigate if addition of metformin to standard care (life-style advice) reduces the occurrence of cardiovascular events and death after myocardial infarction (MI) in patients with newly detected prediabetes. Methods: The Myocardial Infarction and new treatment with Metformin study (MIMET) is a large multicentre registry-based randomised clinical trial (R-RCT) within the SWEDEHEART regis
BACKGROUND: A prolonged QT interval plays a causal role in fatal arrhythmia and is known to be a risk factor for sudden cardiac death. Although diabetic patients with microvascular complications tend to have a longer QT interval, the therapeutic effect of diabetes on the QT interval remains unclear. Here, we assessed the changes in QT interval in patients with type 2 diabetes (T2D) who received mu
Purpose: There is a growing literature on the importance of cultural adaptation of research-supported social work interventions. Few studies have however offered systematic methods for the a priori assessment of intervention fit in a new context. The current study explores the use of measurement invariance analyses to help identify whether key theoretical constructs in an intervention’s theory of
Introduction As care and rehabilitation poststroke are increasingly moving into persons’ home environment, the importance of support from social networks in self-management and rehabilitation has emerged as an important topic for research and practice. While there are instruments used to assess social support and collective efficacy, a clearer scope of the availability and quality of these instrum
Background: Japan lacks efficient assessment tools for occupational balance (OB) in people with mental illness (MI). Aims/objectives: We investigated the test–retest reliability and construct validity of a Japanese version of the Satisfaction with Daily Occupations and Occupational Balance (SDO-OB-J) for people with MI. Methods: SDO-OB-J interviews were conducted twice at a 2-week interval. Result
Background. The debate about increased welfare and health service costs is well-known in relation to the growing ageing population. Over the past thirty years, ageing in place has been the guiding principle for policies concerning older people and housing in Sweden and other Western countries. Sweden is among the countries in the European Union and internationally whose populations have the longes
Background: Cardiac arrhythmias are a common health problem. Both common and rare genetic risk factors exist for cardiac arrhythmias. Cardiac amyloidosis is a rare disease that may manifest various arrhythmias. Few large-scale whole exome sequencing studies elucidating the contribution of rare variations to arrhythmias have been published. Objective: To access gene collapsing analysis of rare vari
A series of quinone-based compounds were tested for their ability to act as external electron acceptors in the 1-dehydrogenation of-αmethyl-hydrocortisone-21-acetate, with polyurethane-entrapped Arthrobacter simplex cells in buffer-saturated n-decan-1-ol. This organic solvent was needed to solubilize the steroid substrate. In aqueous medium, the conversion with free cells virtually stopped after o
Popular Abstract in Swedish Växter får energi att växa till och fortplanta sig genom fotosyntes och cellandning. Vid fotosyntesen använder växterna ljusenergin från solen medan vid cellandningen kolföreningar bryts ner för att frigöra den energi som behövs till olika kemiska processerna i cellen. Enzymer är proteiner som katalyserar dessa kemiska processer. För att omvandla ett utgångsämne (t ex sMost cells are crowded with solutes, enzymes, nucleic acids, structural proteins and membranes. Crowding promotes macromolecular interactions and determines major properties of the cellular environment such as viscosity, diffusion and inhomogeneity. Macromolecular interactions that involve enzymes can affect the kinetic and regulatory properties of these, hence the interactions are part of the met
Supercritical fluid extraction (SFE) is a green alternative method of extraction for neutral lipids in seeds compared to conventional methods utilizing organic solvents. In this work, a novel method where SFE is hyphenated with an evaporative light scattering detector is presented. The method was subsequently applied to determine lipid content in crushed linseed. The new method enables rapid quant
The Archaean block of southern Greenland constitutes the core of the North Atlantic craton (NAC) and is host to a large number of Precambrian mafic intrusions and dyke swarms, many of which are regionally extensive but poorly dated. For southern West Greenland, we present a U-Pb zircon age of 2990 +/- 13 Ma for the Amikoq mafic-ultramafic layered intrusion (Fiskefjord area) and four baddeleyite U-
The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy root s = 8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb(-1). No
A search for an excess of events with multiple high transverse momentum objects including charged leptons and jets is presented, using 20.3 fb(-1) of proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2012 at a centre-of-mass energy of root s = 8 TeV. No excess of events beyond Standard Model expectations is observed. Using extra-dimensional models for blac
BACKGROUND: In preterm infants, low levels of insulin-like growth factor-I (IGF-1) and IGF binding protein 3 (IGFBP-3) are associated with impaired brain growth and retinopathy of prematurity (ROP). Treatment with IGF-I/IGFBP-3 may be beneficial for brain development and may decrease the prevalence of ROP. METHODS: In a phase II pharmacokinetics and safety study, five infants (three girls) with a
Pressurized liquid extraction (PLE) was investigated for the extraction of two endosulfan isomers and their metabolite from two real contaminated soil samples. PLE for 3 x 10 min at 100 degrees C was proven to be more exhaustive than Soxhlet extraction (SOX) in one soil sample. On the other soil sample investigated the method was found to be equally exhaustive as SOX. The use of hazardous organic
Popular Abstract in Swedish Denna avhandling utgöres av två separata rapporter, där studieobjektet för den första är en vektorvärd Sturm-Liouville ekvation på formen -(PU')'+QU=zU, xin[0,b), med P^{-1},W,Q hermiteska med lokalt integrerbara matriselement; och under vissa ytterligare villkor på P^{-1} och W. Under dessa förutsättningar härleds några huvudresultat beträf- fande asymptotiken, då z igThis discourse is constituted by two separate reprots, where the first one offers an elementary deduction of the leading order term asymptotics for the Titchmarsh-Weyl M-function corresponding to a vector-valued Sturm-Liouville equation of the form -(PU')'+QU=zu, xin[0,b), with P^{-1},W,Q being hermitean with locally integrable entries; and under some additional conditions on P^{-1} and W. In the
PURPOSE:: The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made. METHODS:: A thorough search for the total number of patients with aniridia in Sweden and Norway was performed. One hundred eighty-one patients we
Climate change is already contributing to the displacement of millions of people worldwide as extreme weather events become increasingly frequent and intense. Proposals for responding to the phenomenon of climate change-related displacement overwhelmingly rely on the state to act, with limited discussion of the potential to determine and develop the scope of protection through strategic litigation
