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Prior studies, utilizing interview-based assessments, suggest that most of the genetic risk factors for drug abuse (DA) are non-specific with a minority acting specifically on risk for abuse of particular psychoactive substance classes. We seek to replicate these findings using objective national registry data.
Data concerning the importance of family history of venous thromboembolism (VTE) for the risk of recurrent VTE are sparse. The aim of this nationwide study was to determine whether family history of VTE is a risk factor for recurrent hospitalization for unprovoked VTE (deep venous thrombosis of the lower extremities or pulmonary embolism).
BACKGROUND: Earlier studies have suggested that type 2 diabetes mellitus (T2DM) alters the risk of developing a variety of cancers, but little has been known about the impact of T2DM on cancer prognosis. On the basis of nationwide population-based Swedish registries, the authors of this report compared the cause-specific survival among cancer patients with and without T2DM. METHODS: Patients with
It is known that overweight is associated with chronic knee pain (CKP) and chronic low back pain (CLBP). Several risk factors for these conditions have been postulated, including age, sex, overweight, occupation, and socioeconomic factors. In addition, physical environment has been studied as a potential risk factor in recent years. However, the associations of overweight and physical environment
Infectious etiologies have been hypothesized for acute leukemias because of their high incidence in early childhood, but have seldom been examined for acute myeloid leukemia (AML). We conducted the first large cohort study to examine perinatal factors including season of birth, a proxy for perinatal infectious exposures, and risk of AML in childhood through young adulthood. A national cohort of 3,
Cigarette smoking is associated with amyotrophic lateral sclerosis (ALS), but the association between alcohol consumption and ALS is not clear. Our aim was to clarify this using a national cohort study design in Sweden.
Attention-deficit/hyperactivity disorder (ADHD) predisposes to drug abuse (DA) and twin studies suggest shared genetic effects. We here seek to determine, using adoption and adoption-like samples, the magnitude of the cross-generational transmission from DA in parents to ADHD in their children and clarify the degree to which this arises from genetic v. rearing effects.
Genetic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of pre-eclampsia/eclampsia (PEC/EC). This nationwide study aimed to determine whether VTE shares familial susceptibility with PEC/EC.
In the developed countries the public expect society to be prepared for, and step in, if something out of the ordinary happens. This public pressure appears to have increased the demand for crisis preparedness planning. In crisis management the local authority serves as the first line of defence and will more or less always be involved in responding to crises. It is therefore important to study ho
The paper presents a review of the scientific literature on computer modeling of socio-technical systems. The aim is to briefly review and discuss modeling approaches that are suitable for the simulation of socio-technical systems, specifically in the context of risk and vulnerability analysis of critical infrastructures. It is found that seven main socio-technical modeling approaches can be disce
Yersinios och shigellos är två bakterieburna och livsmedelsrelaterade sjukdomar som medför betydande kostnader i termer av direkta kostnader (kostnader för vård, medicin, rehabilitering etc.), indirekta kostnader (produktionsbortfall till följd av sjukfrånvaro) och immateriella kostnader (obehag, illamående och dylika immateriella aspekter som kan kopplas till sjukdomen). Det är väsentligt att upp
Information from performed risk and vulnerability analyses, evaluation of responses in relation to actual emergencies etcetera can be very useful in efforts directed at preventing, mitigating and/or preparing for future emergencies. This thesis focuses on the development of methods for such analysis and evaluation. A general process for systematic design of methods is introduced and discussed and
This paper presents a case study of decision-making at the design stage of a socio-technical system where resilience at the global level of the system was constrained by the local perspectives adopted by the different stakeholders. The study is based on interviews with key decision-makers involved in the design stage of six railway tunnel projects in Sweden. The results show that differences in ro
