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Altered protein handling is thought to play a key role in the etiopathogenesis of Parkinson's disease (PD), as the disorder is characterized neuropathologically by the accumulation of intraneuronal protein aggregates (Lewy bodies and Lewy neurites). Attention has particularly focused on the alpha-synuclein protein, as it is the principal component of Lewy pathology. Moreover, point mutations in th

Context: DevOps, the combination of Development and Operations, is a new way of thinking in the software engineering domain that recently received much attention. Given that DevOps is a new term and novel concept recently introduced, no common understanding of what it entails has been achieved yet. Consequently, definitions of DevOps often only represent a part that is relevant to the concept. Obj

Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile resp

A hallmark of an evidence-based practice (EBP) is the systematic appraisal of research related to the effectiveness of interventions. This study addressed the issue of interpreting results from effectiveness studies that use treatment-as-usual (TAU) as a comparator. Using randomised controlled studies that evaluate the effectiveness of multisystemic therapy as an illustrative example, we show that

Bladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate. In this study, we explored the clinical and functional associations of CD44v6 expression in bladder cancer. Integrated analyses of patient samples and cell lines showed that h

This study is an effort to find a connection between the high number of people on sick leave, the occupational health situation at the workplace, and stronger market competition and globalisation forces. The basis for the study is statistics, mainly on injuries and diseases, interviews with people in different positions with either long experience within the safety and health situation or otherwi

The genomic conflict between the sexes is caused by differences in the optimal male and female reproductive strategies, and is a major contributor to genetic, phenotypic, and life history variation. While early experimental work appeared to strongly support predictions from sexual conflict, recent work has produced more ambiguous results. Recent advances in experimental evolution studies combined

PARP14 is a mono-ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed. We show that PARP14 is a dual-function enzyme with both ADP-ribosyl transferase and hydrolase activity act

Cupriavidus is a bacterial genus related to Burkholderia, with members that can be negative or positive for us. Some species can give people serious, and even deadly diseases. Among the species positive for us is one that can be used for replacing plastic production from fossil oil by a more sustainable method.

Objective: Progressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the previously identified neuroprotective antipsychotic clozapine in vitro and in chronic experimenta

Aim: To define the genomic distribution and function of DNA methylation changes during human adipogenesis. Methods: We isolated adipocyte-derived stem cells from 13 individuals and analyzed genome-wide DNA methylation and gene expression in cultured adipocyte-derived stem cells and mature adipocytes. Results: We observed altered DNA methylation of 11,947 CpG sites and altered expression of 11,830

Since the popular uprising and subsequent war in Syria in 2011, more than a quarter of its population have fled – mainly to Turkey, Lebanon, Jordan, Iraq and Egypt – and another 25% have been internally displaced. The end of 2017 saw 12.6 million Syrians forcibly displaced – 6.3 million refugees, 6.2 million internally displaced (IDPs) and 146,700 asylum-seekers. In the words of the United Nations

In this article, we explore why solidarity has not worked according to expectation in EU migration and asylum law, and why it is unlikely to work in the future. First, we explore discourses of burden-sharing and solidarity in EU law from the 1990s up to the Lisbon treaty in 2009 to identify emergent path dependencies. This period saw the introduction of primary law provisions on solidarity, such a

This chapter aims to explore community energy (CE)—energy communities that are established and run by private citizens—in four Eastern European countries. The chapter first analyses general contextual conditions supporting the diffusion of CE initiatives in the Baltic Sea Region. Subsequently, it reports the findings of four case studies from Estonia, Latvia, Lithuania, and Poland illustrating som

Various concepts guide discussions on global literature, not least ›transnational‹. The presenttext advocates, however, for the term trans-imperial, as offering a more correct definitionof world literature, or global literature, both in pre-modern and modern times. Imperialspheres build up worlds of strong interconnections, and the languages they employ becomeprivileged languages that may last bey