Filetype
To understand why immune traits affect the fitness of its host is an important part of understanding why and how immune responses evolve. In threespine stickleback (Gasterosteus aculeatus), fibrosis is an immune response evolved to combat infection of the tapeworm parasite Schistocephalus solidus. Already known is that fibrosis leads to a reduced mating success for males. Here I investigated wheth
Aims The aim of this study was to investigate genetic variants in the gene NCF1 for association with Rheumatoid Arthritis (RA). In rodent models, a single nucleotide polymorphism (SNP) in Ncf1 has been shown to be a major locus regulating severity of arthritis. Ncf1 encodes one of 5 subunits of the NADPH oxidase complex. In humans the genomic structure of NCF1 is complex, excluding it from genome
We previously demonstrated that hyperglycemia could suppress apolipoprotein M (apoM) synthesis both in vivo and in vitro; however, the mechanism of hyperglycemia-induced downregulation of apoM expression is unknown yet.
Purpose: The term “love brand” has recently become a buzzword among marketing practitioners. Therefore, the purpose of this paper is to define this concept, its elements, and how customers express the love they feel towards their love brand(s) in order to create a shared understanding among practitioners and the academic world. Methodology: First, a literature review is used to identify related t
Key words: sustainability, hotel reviews, tourism, online reviews
Abstract: During the last couple of decades the spread of wages has increased throughout the western world. Sweden is no exception from this trend, and the increased wage inequality in Sweden can be traced back 1980. This thesis aims to answer whether technology driven changes in demand for labor can explain changes in relative wage, and if increased foreign competition can explain increasing wage
China is experiencing a rapid economic transformation, which witnesses a vast number of labourers moving out of agricultural sectors. In such a transformation, the effect of spatial income variance on labour’s off-farm work decision is still unclear. Based on the cross-sectional data from the national survey conducted in 2012, this study finds the effect on two kinds of off-farm employment, wage e
The purpose of this paper is to explore overarching themes regarding identity and the HR department. Our aim is to address some of the more recent developments in HR identity issues, such as dis-identification and how it relates to the changes that have occurred of late within the HR department.
Translocation of the tRNA·mRNA complex through the bacterial ribosome is driven by the multidomain guanosine triphosphatase elongation factor G (EF-G). We have used isothermal titration calorimetry to characterize the binding of GDP and GTP to free EF-G at 4°C, 20°C, and 37°C. The binding affinity of EF-G is higher to GDP than to GTP at 4°C, but lower at 37°C. The binding enthalpy and entropy chan
In this paper, we aim to contribute to an enhanced theoretical ground for Universal Design (UD) by examining the concept of “inclusion”, presenting a conceptual critique of it based on our research on categorisation and UD, and proposing a way forward. This study is based on a comprehensive analysis of a range of photographs related to inclusion and exclusion collected during five recent research
Controllable hydrogen generation rate of Al-Ga-based on-site hydrogen supply materials significantly impacts their practical application. In many scenarios, the hydrolysis reaction occurs at elevated temperatures, which is a factor often overlooked in its effect on reaction kinetics. This study investigates the relationship between grain size and reaction rate in Al-Ga-based alloys for hydrogen ge
Nature-Based Solutions (NBS) is an emerging concept which has the potential to address several sustainability challenges. In this multiple case study research on three NBS projects in Gothenburg (Sweden) the projects objectives and evaluated impacts are studied to provide insights into how NBS interventions are implemented in urban contexts. In addition, barriers and drivers for up-scaling are ide
The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-3. PARP-3 is not activated upon binding to DNA and is a mono-ADP-ribosylase, in contrast to PARP-1 a
This dissertation aims to contribute to sociology, citizenship studies and disability studies by responding to T.H. Marshall’s ([1950]1992) invitation to examine the development of equal citizenship in a context of structural inequality, and Jenkins’ (1991) call to consider disability as a dimension of social stratification. Based on the analysis of blog posts and debate articles published in dail
What's in the Syringe? offers a succinct overview of the psychological skills of outpatient palliative care, teaching clinicians how to help patients live well and acknowledge end of life as patients meet five challenges of serious illness. It explores how to help patients develop prognostic awareness, through which they pair hopes and worries and see themselves with clarity and empathy. The book
This study seeks to explain how Chinese state media bolster the use of visions in global internet governance. The empirical data for the article consists of 1,158 internet related articles published in the Global Times between 2009 and 2018. I develop a theoretical perspective that distinguishes between grand and strategic narratives. Based on a mixed-methods approach, I show that “internet sovere
Breast and gynecologic cancers harboring PIK3CA mutations showed no significant responses to AZD5363, a pan-AKT catalytic inhibitor, in contrast with previous in vitro data showing activity of the drug in this subset of cancers. These results raise the question of how to select the most accurate predictive biomarkers of response.
