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An Ultrahigh‐Density Microneedle Array for Skin Vaccination: Inducing Epidermal Cell Death by Increasing Microneedle Density Enhances Total IgG and IgG1 Immune Responses

Many types of microneedle (MN) arrays have been tested for delivery of vaccines to the skin. However, the effect of MN geometry/array design on antibody production is still unclear. Reports suggest that systemic immune responses may be affected by how MN arrays “mechanically” deliver vaccines, which can induce cell damage and act as an adjuvant. This includes parameters such as MN length/insertion

Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor

Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural details, as well as the exact physiological role of this interaction, remain unclear. Here, we describe the structural details of the SEA–gp130 c

An integrated approach to Archaeology: From the Fieldwork to Virtual Reality Systems

The visualisation of an archaeological landscape passes through its representation, interpretation and reconstruction. Its various and complex aspects can be described just through an integrated approach of disciplines, data and technologies. Two directions have been undertaken by our research team: a narrative approach and a geographical-spatial one. The narrative approach to cultural data is foc

Robot control methods and results from user trials on the RAID workstation

CERTEC intends to develop an autonomous grasping function, but first user requirements have to be studied. Therefore, user trials have been carried out on the RAID workstation (Robot to Assist the Integration of the Disabled) at the Rehabcentrum Lund-Orup in Höör, Sweden. This paper will describe the control methods used in these trials as well as the results of the trials.

Fornminnen : det förflutnas roll i det förkristna och kristna Mälardalen

Popular Abstract in Swedish I vår egen tid finns ett stort intresse för släktforskning och historia hos många. Men man tänker sällan på att även människor i gångna tider kunnat blicka tillbaka på sitt förflutna och fundera på sin egen plats i släktleden. Vad var de ville minnas och hur mindes de i en tid utan skriv- och läskunnighet? Det är frågor som ställs i avhandlingen och där svaren söks i deThis thesis examine how farm-dwellers in the Mälaren region during the late Iron Age and early Middle Ages created, transferred, and preserved memory by deliberately placing new houses and graves on the houses and graves of previous generations. Focus is on memory as a social phenomenon and culture-specific resource created by these deliberate practices. The culture-specific element is oral cultur

Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro

Beta cell apoptosis is a hallmark of diabetes. Since we have previously shown that galectin-3 deficient (LGALS3/) mice are relatively resistant to diabetes induction, the aim of this study was to examine whether beta cell apoptosis depends on the presence of galectin-3 and to delineate the underlying mechanism. Deficiency of galectin-3, either hereditary or induced through application of chemical

Känslor i krig. Sensibilitet och emotionella strategier bland svenska officerare 1788–1814

Emotions at War: Sensibility and emotional strategies among Swedish officers, 1788-1814 This thesis studies the relationship between the emotional sufferings of Swedish officers in wartime during the period 1788-1814 and the various mental strategies they employed in order to deal with those sufferings. The study is positioned within the field of research commonly refered to as the history of em

Surface phase diagram and temperature induced phase transitions of Sn/Cu(100)

Room temperature deposition of Sn on Cu(100) gives rise to a rich variety of surface reconstructions in the submonolayer coverage range. In this work, we report a detailed investigation on the phases appearing and their temperature stability range by using low-energy electron diffraction and surface X-ray diffraction. Previously reported reconstructions in the submonolayer range are p(2 x 2) (for