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Many proteins rely on rare structural fluctuations for their function, whereby solvent and other small molecules gain transient access to internal cavities. In magnetic relaxation dispersion (MRD) experiments, water molecules buried in such cavities are used as intrinsic probes of the intermittent protein motions that govern their exchange with external solvent. While this has allowed a detailed c

Overweight and obesity among children has gained increased attention as one of the most unequally distributed health problems. This article draws on interviews with school nurses, who in their daily work handle this problem. Their responses articulate a discrepancy between the general view on overweight and obesity as a “disaster” for the afflicted children and the practice of turning "a blind eye

Hydrophobic hydration, the perturbation of the aqueous solvent near an apolar solute or interface, is a fundamental ingredient in many chemical and biological processes. Both bulk water and aqueous solutions of apolar solutes behave anomalously at low temperatures for reasons that are not fully understood. Here, we use 2H NMR relaxation to characterize the rotational dynamics in hydrophobic hydrat

In recent years, the antibody microarray technology has made significant progress, going from proof-of-concept designs to established high-performing technology platforms capable of targeting non-fractionated complex proteomes. In these cross-disciplinary efforts, a particular focus has lately been placed on two key technological issues: the sample and data handling. To this end, robust protocols

Abstract is not available

A developing system must be able to learn new things without forgetting what it has learned before. It should be capable of reacting in different ways to the same stimuli in different contexts. Context sensitive reinforcement learning, which parallels some of the functions of the basal ganglia, is a learning algorithm that fulfills this requirement when the context is explicitly given. Here, we ex

The European Union’s sugar policy is one of the most distorting policies within the common agricultural policy. It includes import control, production quota, and export refunds to support producer price within the EU at levels high above international prices. The main beneficiaries of the support system are the EU sugar industries and EU beet growers, but they are not the only producers benefiting

The paper discusses the solution to the optimal adaptive control problem over an extended time horizon. This leads to a controller that have dual features, i.e., tt uses control actions as well as probing actions. The solution of the optimal dual control problem is intractable from a computational point of view. Approximations to obtain simpler suboptimal dual controllers are thus important. There