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When applying conventional immunological assays involving the use of a labeled moiety, sensitivity is gained at the expense of time since equilibrium conditions are a prerequisite for such assays. Since an analysis in this sense may take from several hours to a few days,1,2 much effort has been made lately to shorten the time of assay. This has also (as will be discussed later in the chapter) been
The aggregation of the amyloid-β (Aβ) peptide is linked to the pathogenesis of Alzheimer’s disease (AD). In particular, some point mutations within Aβ are associated with early-onset familial Alzheimer’s disease. Here we set out to explore how the physical properties of the altered side chains, including their sizes and charges, affect the molecular mechanisms of aggregation. We focus on Aβ42 with
We propose a representation of the Indian summer monsoon rainfall in terms of a probabilistic model based on a Markov random field consisting of discrete state variables representing low and high rainfall at grid-scale and daily rainfall patterns across space and in time. These discrete states are conditioned on observed daily gridded rainfall data from the period 2000 to 2007. The model gives us
Due to the significant increase in pediatric trunk computed tomography (CT) examinations, there is a need for a reliable approach of conducting effectivedose estimate for such procedures. The current study is based on two dosimetric anthropomorphic phantoms representing a 1-year and a 5-year old child. Effectiveand equivalent tissue doses from CT examinations of the trunk were determined by thermo
Establishing diagnostic reference levels (DRLs) in a big country is complicated due to differences in radiological practice between different regions. In 2009-2014, a dose survey was performed in six Russian regions. Based on the results of the survey, preliminary DRLs for conventional X-ray examinations were established on a national level. Additionally, the local authorities were granted the pos
The cluster of pathologies comprising the metabolic syndrome (MetS) includes increased waist circumference, hyperglycemia, elevated blood pressure and hyperlipidemia. With time, these conditions present a major risk of developing obesity, type 2 diabetes and atherosclerosis. Fecal microbiota transplant (FMT) experiments performed in mice have given an intriguing foundation for a microbial-based th
The European Union’s capacity for leadership is not just decided by the EU itself. It is also affected by the perceptions of other actors regarding the EU’s role, and by their reactions to its initiatives. The same can be said of the Union’s influence in the international arena, including its capacity to do something about global imbalances. Is the EU perceived as a legitimate actor that has somet
With the arrival of the refugees from the Middle East, especially since 2015, Europe has become a xenophobic hotbed. Discourses, practices, and policies promoting and supporting xenophobia have become reality. In this article, we seek to present stories of those who have arrived to Europea via the Balkan Route, in a qualitative research fashion, concentrating on several narratives collected by the
Hip-related pain is a well-recognised complaint among active young and middle-aged active adults. People experiencing hip-related disorders commonly report pain and reduced functional capacity, including difficulties in executing activities of daily living. Patient-reported outcome measures (PROMs) are essential to accurately examine and compare the effects of different treatments on disability in
The introductory chapter emphasises the general relevance of the study of electoral candidates in representative democracies. It presents the book’s theoretical framework: the triadic delegation and accountability relationship between candidates, voters and parties—based on principal–agent theory. We theoretically map patterns of candidates’ behaviour and attitudes in all main dimensions of their
Mergers of neutron stars (NS) and white dwarfs (WD) may give rise to observable explosive transientevents. We use 3D hydrodynamical (SPH) simulations, as well as 2D hydrodynamical-thermonuclearsimulations (using the FLASH AMR code) to model the disruption of CO-WDs by NSs, whichproduce faint transient events. We post-process the simulations using a large nuclear network andmake use of the SuperNu
