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Hereditary cystatin C amyloid angiopathy is a dominantly inherited disorder, characterized by dementia, paralysis, and death from cerebral hemorrhage in early adult life. A variant of the cysteine proteinase inhibitor, cystatin C, is deposited as amyloid in the tissues of the patients and their spinal-fluid level of cystatin C is abnormally low. The disease-associated Leu-68-->Gln mutant (L68Q) cy

Digitalization is transforming the tax landscape, reshaping the operations of tax departments, authorities, and professionals. With rapid digital advancement, there has been a shift toward real-time reporting, e-invoicing, and greater reliance on digital data. This change is driven by investments in data analytics, robotic process automation, cloud platforms, and, more recently, artificial intelli

This study explores structural modifications for reducing train-induced vibrations in timber buildings by modifying the building layout. A parameter study was conducted using a semi-analytical ground model coupled with a finite element structural model. The train load was modeled as a stationary oscillating point load of unit magnitude, applied on the ground surface. The analyzed frequency range,

Som en reaktion på Rysslands fullskaliga invasion av Ukraina har EU och allierade G7-länder infört omfattande sanktioner riktade mot rysk olja och petroleumprodukter. För att kringgå dessa sanktioner har Ryssland i allt större utsträckning förlitat sig på en parallell flotta – en så kallad skuggflotta – som har kommit att spela en betydande roll i finansieringen av den ryska krigföringen. SkuggfloIn response to Russia’s full-scale invasion of Ukraine, EU and allied G7 countries implemented extensive sanctions regimes targeting Russian oil and petroleum products. To circumvent these sanctions, Russia has increasingly relied on a parallel fleet operating without Western ties – a shadow fleet – which has come to play an important role in funding the Russian war effort. Shadow fleet vessels em

This study is part of a North West Europe (NWE) Interreg project called NWE-REGENERATIS that aims at the regeneration of past metallurgic sites and deposits through innovative circularity for raw materials. A novel geophysical methodology is developed to allow a 2D or 3D characterization of the recoverable metallic particles in terms of volume, type and grain sizes. We propose to integrate multi-m

Collective action problems emerge when individual incentives and group interests are misaligned, as in the case of climate change. Individuals involved in these problems are generally considered to have two options: contribute toward public solutions such as global warming mitigation or free ride. However, many collective action problems today involve a third option of investing in a “private solu

This article is based on ethnographic fieldwork carried out among what Lian Si (2009) has called China’s ‘ant tribe’, referring to the millions of unemployed Chinese college graduates who live in the outskirts of Beijing and to some extent share the predicament of China’s migrant workers. Education has been the main route to social mobility for centuries in China, but today college graduates are o

Quantum information and quantum computing are based on the concept and manipulation of qubits. In this pedagogical Tutorial-written with the aim of assisting self-motivated undergraduate mathematics, physics, and engineering students-transformation of these qubits, especially the Hadamard transformation (H) and the phase shifter transformation (φ), is illustrated. Two-qubit gates and their applica

Nurse turnover is a central driver of the growing care deficits that characterise contemporary capitalism. In Sweden, despite policy efforts to improve retention, nurse shortages persist – destabilising care provision and intensifying workplace strain. This article explores how turnover and employer responses in the Swedish healthcare sector reflect the contradictory dynamics of market culture. Dr