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Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated

LTRs of endogenous retroviruses are known to affect expression of several human genes, typically as a relatively minor alternative promoter. Here, we report that an endogenous retrovirus LTR acts as one of at least two alternative promoters for the human beta1,3-galactosyltransferase 5 gene, involved in type 1 Lewis antigen synthesis, and show that the LTR promoter is most active in the gastrointe

A quantitative reverse transcription-PCR (qRT-PCR) method was developed to monitor the relative expression of the type B botulinum neurotoxin (BoNT/B) gene (cntB) in Clostridium botulinum. The levels of cntB mRNA in five type B strains were accurately monitored by using primers specific for cntB and for the reference gene encoding the 16S rRNA. The patterns and relative expression of cntB were dif

Human endogenous retroviruses (HERVs) are estimated to represent at least 1% of the human genome. An HERV-H env SU sequence (HERV-H19) was used to screen the high-throughput (htgs) and nonredundant (nr) databases for other HERV-H SU open reading frames (ORFs) and thus possible functional proteins. Using PCR with primers derived from HERV-H19 SU, we also obtained several new sequences with ORFs fro

Large-scale protein conformational motions on nanosecond – microsecond time scales are important for many biological processes, but remain largely unexplored because of methodological limitations. NMR relaxation methods can access these time scales if protein tumbling is prevented, but the isotropy required for high-resolution solution NMR is then lost. However, if the immobilized protein molecule

Thermally driven rotational and translational diffusion of proteins and other biomolecules is governed by frictional coupling to their solvent environment. Prediction of this coupling from biomolecular structures is a longstanding biophysical problem, which cannot be solved without knowledge of water dynamics in an interfacial region comparable to the dry protein in volume. Efficient algorithms ha

Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells (LT-HSCs) from young and old mice. We found t

Microsoft Word - Allm studieplan fhvet2016.doc   Postadress  Box  117,  221  00    LUND    Telefon  växel  046-­‐222  00  00    Telefax  046-­‐222  41  70       E-­‐post  info@med.lu.se  Internet  http://www.med.lu.se       Medic inska   faku l te tss tyre lsen               Allmän   studieplan   för   utbildning   på   forskarnivå   i   folkhälsovetenskap   http://www.med.lu.se/utbildning/forskar

https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-folkhalsovetenskap-2016-01-01.pdf - 2026-05-30

Allm studieplan lab med 2017 Postadress Box 117, 221 00 LUND Telefon växel 046-222 00 00 Telefax 046-222 41 70 E-post info@med.lu.se Internet http://www.med.lu.se Medic inska faku l te tss tyre lsen Allmän studieplan för utbildning på forskarnivå i laboratoriemedicin http://www.med.lu.se/utbildning/forskarutbildning (Fastställd av Medicinska fakultetsstyrelsen 2007-05- 24) Studieplanen träder ikra

https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-laboratoriemedicin-2017-01-01.pdf - 2026-05-30

Microsoft Word - Allm studieplan lab med 2016.doc   Postadress  Box  117,  221  00    LUND    Telefon  växel  046-­‐222  00  00    Telefax  046-­‐222  41  70       E-­‐post  info@med.lu.se  Internet  http://www.med.lu.se       Medic inska   faku l te tss tyre lsen               Allmän   studieplan   för   utbildning   på   forskarnivå   i   laboratoriemedicin   http://www.med.lu.se/utbildning/fors

https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-laboratoriemedicin-2016-01-01.pdf - 2026-05-30

Swedish has – like other Germanic languages – flexible stress placement, which underlies morphological rules and is also based on the individual word’s origin. The achievement of the correct usage when learning Swedish is challenging. As second language learners of Swedish in the classrooms present speakers of a variety of first languages (L1s), the opportunity has been taken to have a closer look

Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since galectins have been implicated in mechanisms of both chronic inflammation and cancer, we have inves

Lipid-binding proteins Sequester amphiphilic molecules in a large internal : cavity occupied by similar to 30 water molecules, some of which are displaced by the ligand. The role; of these internal water molecules in lipid binding and release is not understood. We use magnetic relaxation dispersion (MRD) to directly monitor internal-water dynamics in apo and palmitate-bound rat intestinal fatty ac

This paper examines vowel-to-vowel lingual coarticulation in sequences of vowel-bilabial consonant-vowel, where the duration of the oral closure for the consonant is either long or short. Native speakers of Japanese served as subjects. The linguistic material consisted of Japanese word pairs that only differed in the duration of the labial consonant, which was either long or short. Recordings were