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The human host-defense peptide LL-37 not only displays antimicrobial activity but also immune modulating properties that trigger intracellular signaling events in host cells. Since the cytolytic activity of high LL-37 concentrations affects cell viability, the function of LL-37 requires tight regulation. Eukaryotic cells therefore benefit from protective measures to prevent harmful effects of LL-3

In this thesis I discuss about economical and political transition in countries that is consecutively being induced by influential external actors. Looking closer on the role of the EU as a dynamic transitional force, with the intention of examining to what extent the EU can pursuit its interest and modify the economical as well as the political structures of transition countries. With relations t

This chapter presents life cycle assessment (LCA) and its current and potential use as a tool of governance. LCA is considered as providing governance input in three different dimensions: (1) as results; (2) as a method; and (3) as a mindset. Life cycle approaches are increasingly informing policymaking and legislation, either as an abstract idea such as “the circular economy” or as calculation ru

The narrative of domestic fiction frequently depicts a woman’s search for domestic bliss, as a mother, wife, and homemaker. Shirley Jackson has often contested this narrative by portraying female characters who, through uncanny manifestations of repressed desires and fears, go against these norms. ‘The Deamon Lover’ (1949) and ‘The Tooth’ (1949) present two female protagonists, who are confronted

The paper gives a brief presentation of the cultural and institutional specificities of Sweden and how these cultural and institutional specificities impact the development of the Swedish social welfare system over periods of change, transition and strategic adjustment. The paper concludes by presenting a suggestion of a new view of the relationship between culture and social welfare systems, whic

Astaxanthin (AXT) is a reference model of xanthophyll carotenoids, which is used in medicine and food industry, and has potential applications in nanotechnology. Because of its importance, there is a great interest in understanding its molecular properties and aggregation mechanism in water and mixed solvents. In this paper, we report a novel model of AXT for molecular dynamics simulation. The mod

Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NOx) among PE cases and normotensive controls influence DNA methylation

Background and purpose — There is an ongoing debate regarding the appropriate level of constraint in primary TKA. To provide increased stability and better kinematics, more resembling a natural knee, a medial congruent (MC) tibial insert has been introduced. To investigate potential impact on implant migration, we evaluated the cemented Persona TKA, randomizing between MC and cruciate-retaining (C

Randomised controlled trials conducted using cohorts and routinely collected data, including registries, electronic health records and administrative databases, are increasingly used in healthcare intervention research. A Consolidated Standards of Reporting Trials (CONSORT) statement extension for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) has been developed with

In order to develop new environmental policies, it is important first to evaluate those that have already been used. However, this intuitively simple idea is difficult to apply in practice, no more so than in the complex governance context of the EU. Attributing impacts to specific policies is challenging, and making evaluations useful for political decision making is even more demanding. Five app

Austrian artist and director of ZKM Center for Art and Media in Karlsruhe, Germany, Peter Weibel (Odessa, 1944), curates a book/catalogue of the mythical exhibition Sound Art, Sound as Medium of Art, that took place between March 2012 and February 2013 in Karlsruhe, with nearly one thousand images of sound art pieces. Along with a very detailed historical trace of sound as a form of art, the book

This study examines the differences and similarities in the news media’s portrayal of political topics related to artificial intelligence in the United States and Sweden. AI is increasingly politicized but is poorly understood from a political science perspective. By examining these two innovative and prosperous countries’ media landscapes, it aims to further our understanding of the cross-nationa

Background: Expanding access to self-management via Digital Health Technologies may supplement traditional care, mitigating pressures on primary care through self-management. Primary Care Physicians (PCP) can play a critical role in the integration of digital health technologies into patient care, but it is unclear what factors influence PCPs’ recommendation of such technologies. Aims: To identify

In 2024 the European Declaration of Cycling was signed as a tri-institutional declaration by the European Commission, Council of the European Union and the European Parliament. For the first time, cycling was acknowledged as a fully fledged mode of transport in a EU-level framework and through it, cycling now sits officially on the agenda of the EU. Yet this level of political attention was for ma

In this introductory chapter we chart colonial aspirations and projects of early modern Scandinavian kingdoms and discuss political and economic thinking that fuelled and justified these projects. We situate Danish and Swedish colonial venture, ideology and economic concerns that stood behind the global expansion in the context of contemporary European thinking and politics.