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Greek collections of the Apophthegmata Patrum as found in Scorialensis R.II.1 and related manuscripts

The so called Collectio Scorialensis parva is an unedited alphabetical collection of stories about Egypti an desert fathers. It is found in two Greek MSS: Scorialensis R.II.1 and Parisinus gr. 919. They also contain a larger collection of the Apophthegmata Patrum, the so called alphabetica - anonyma derivata. Other manuscripts preserve this latter collection in a later stage, where all or parts of

Molecular origin of time-dependent fluorescence shifts in proteins

Time-resolved fluorescence spectroscopy is used increasingly to probe molecular motions at the aqueous interfaces of biological macromolecules and membranes. By recording the time variation of the fluorescence frequency, thermal atomic fluctuations in the vicinity of the chromophore can be probed. From such fluorescence Stokes shift (FSS) experiments, it has been inferred that water motions in the

Antibody microarrays: Current status and key technological advances

Antibody-based microarrays are among the novel classes of rapidly evolving proteomic technologies that holds great promise in biomedicine. Miniaturized microarrays (< 1 cm(2)) can be printed with thousands of individual antibodies carrying the desired specificities, and with biological sample (e.g., an entire proteome) added, virtually any specifically bound analytes can be detected. While consumi

The kinetics of leucocyte migration into rabbit knee joints elicited by preformed immune complexes with different in vitro characteristics

Immune complexes were formed in vitro with antibodies obtained from rabbits immunized with bovine serum albumin in Freund's complete (FCA) or incomplete (FIA) adjuvant. The antibodies were mixed with different amounts of antigen. Immune complexes formed at maximum precipitation proportions were efficient in complement activation, whereas immune complexes formed at antigen excess had weak complemen

Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease.

In Huntington's disease (HD), cognitive symptoms and cellular dysfunction precede the onset of classical motor symptoms and neuronal death in the striatum and cortex by almost a decade. This suggests that the early cognitive deficits may be due to a cellular dysfunction rather than being a consequence of neuronal loss. Abnormalities in dendritic spines are described in HD patients and in HD animal

Reverse pharmacology and the de-orphanization of 7TM receptors

Approximately 800 genes coding for seven-transmembrane, G-protein-coupled receptors have so far been recognized. In spite of this, many of these receptors are defined by their sequence only, and are therefore classified as orphan receptors. Without knowing what their endogenous ligands are, we lack the information needed to understand their physiological role and hence cannot make use of them as d

Anisotropic micro-sphere-based finite elasticity applied to blood vessel modelling

A fully three-dimensional anisotropic elastic model for vascular tissue modelling is here presented. The underlying strain energy density function is assumed to additively decouple into volumetric and deviatoric contributions. A straightforward isotropic neo-Hooke-type law is used to model the deviatoric response of the ground substance, whereas a micro-structurally or rather micro-sphere-based ap

The Circumstances of Intergenerational Justice

Some key political challenges today, e.g. climate change, are future oriented. The intergenerational setting differs in some notable ways from the intragenerational one, creating obstacles to theorizing about intergenerational justice. One concern is that as the circumstances of justice do not pertain intergenerationally, intergenerational justice is not meaningful. In this paper, I scrutinize thi

Human blood dendritic cell subsets exhibit discriminative pattern recognition receptor profiles.

Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as TLRs and CLRs, enable antigen recognition and mediate appropriate immune responses. Distinct subsets of human DCs have been identified; however their PRRs expressions are not fully clarified. Especially, expressions of CLRs by DC subpopulations remain el

How can meaningfulness be created in the design process? The case of young disabled users.

It is well-known that the participation in a design process can be experienced as being so meaningful that the participation in itself overshadows even the result of that process. The participants in this design project represent a user group that often use products in which functional value is pre-eminent: people with disabilities. Thereby special attention has been given to the concepts of stigm