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The ribosomal protein S19 (RPS19) is located in the small (40S) subunit and is one of 79 ribosomal proteins. The gene encoding RPS19 is mutated in approximately 25% of patients with Diamond-Blackfan anemia, which is a rare congenital erythroblastopenia. Affected individuals present with decreased numbers or the absence of erythroid precursors in the bone marrow, and associated malformations of var
Background: Dihydrotestosterone (DHT), the most potent ligand to the androgen receptor, is synthesised from testosterone (T) by 5α-reductase type 1 and 2. While type 1 is expressed in several non-reproductive tissues in both sexes, men also express high levels of the high-affinity type 2 isoform in reproductive tissues; yet women have a higher circulating DHT to T (DHT/T) ratio than men. We hypoth
Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the present study, we show for the first time the in situ expression of serglycin by breast cancer cells by immunohistochemistry in patients' material. Moreover, we demonstrate high expression and constitutive secretion of serglycin in the aggressive
Semiconductor billiards are often considered as ideal systems for studying dynamical chaos in the quantum mechanical limit. In the traditional picture, once the electron's mean free path, as determined by the mobility, becomes larger than the device, disorder is negligible and electron trajectories are shaped by specular reflection from the billiard walls alone. Experimental insight into the elect
Objective. Lipid embolizations from retransfused shed blood during cardiac surgery have been shown to enter the circulation and end up in different organs. The purpose of this investigation was to evaluate differences in the kinetics and deposition between emulsified and non-emulsified lipid emboli in a porcine model. Design. Twelve animals were anesthetized and put on cardiopulmonary bypass. A sh
Does it pay to adopt Climate-Smart Practices? Despite the general understanding that CSA practices or innovative land management methods increase farmers’ food security, the key to the current debate within the literature is to understand the extent to which CSA practices explain differences in farmers’ productivity and resilience to climatic shocks. To fill this gap, this study examines the varia
Conventional wisdom suggests, in the face of deepening European integration, that without some form of tax harmonisation "a race to the bottom" would ensue undermining the foundations of Europe's welfare states. Such wisdom can be questioned on two grounds. Firstly, Member States are not on the same "playing field" as there is great disparity between the various Member Stat
Macroeconomic conditions heavily influence financial markets, and the leading corpus of theory in the field lays out some general principles observed by investors and asset managers alike. However, while the theory is sound, it is hard to measure how much effect these conditions have. To better understand this scenario, this study uses a novel technique that combines traditional causal inference w
Merger control is an important component of competition law in the EU. There are two levels of merger control in the EU. The first level is EU merger control for transactions that have an EU dimension, which fall within the jurisdiction of the Commission under the EU Merger Regulation. The second level is national merger control for transactions which do not meet the criteria of the EU Merger Regu
För att skapa nya krypteringsalgoritmer är man alltid på jakt efter svårlösta matematiska problem. Men är alla problem lämpliga? Uppsatsen behandlar Gröbnerbaser över ändliga kroppar och visar att de är inte lämpliga för att bygga säkra krypteringsalgoritmer. Vi undersöker flera möjligheter att knäcka den på Gröbnerbaser baserade krypteringsalgoritmen Polly Cracker, analyserar Differential Attack
Delningsekonomins framfart har inneburit stora positiva effekter på marknaden, genom att bl.a. skapa nya arbetstillfällen och öka konkurrenskraften på marknaden. Det har samtidigt blivit tydligt att traditionell lagstiftning inte helt täcker denna nya affärsmodell och dess aktörer. Intäkterna från delningsekonomin förväntas uppgå till flera miljarder euro årligen, varför det är av stort intresse fThe breakthrough of the sharing economy has resulted in great positive effects on the market, by creating new employment opportunities and increasing the competitiveness on the market. Meanwhile, it has been clear that traditional legislation does not completely cover this new business model and its actors. Revenues from the sharing economy is expected to annually amount to several billion euros,
It is unclear how ammonia is transported by proteins from the Amt/Mep/Rh superfamily. We investigated this for the ammonium transporter TaAMT1;1 from wheat expressed in Xenopus oocytes by two-electrode voltage clamp and radio-labeled uptakes. Inward currents were activated by NH +4 or methylammonium ions (MeA+). Importantly, currents increas
Local democracy is theoretically based on political parties offering different policies across and within sub-national geographical units. However, local democracy is embedded within a multilevel party and institutional structure that may compromise this endeavour. This study develops three expectations of policy variation: within party variation in political positions across geographical units; d
This chapter challenges the widespread belief that shopping provides lasting happiness and stress relief. This myth, often referred to as ‘retail therapy’, suggests that consumption serves as an effective coping mechanism for emotional distress. Rooted in post-war consumer culture and reinforced by advertising, this idea has normalised the use of material goods to manage emotions, fostering a depe
B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. As high levels of Bcl-3 expression and activation have been detected in different types of human cancer, Bcl-3 has been labeled a proto-oncogene. Our study uncovered a markedly upregulated Bcl-3 ex
High tibial osteotomy (HTO) and unicompartmental arthroplasty (UKA) are reconstructive surgeries advocated for younger patients. In case of failure or progression of osteoarthritis, they can both be converted to a total knee arthroplasty (TKA).
The diving response reduces the pulmonary O(2) uptake in exercising humans, but it has been debated whether this effect is present at rest. Therefore, respiratory and cardiovascular responses were recorded in 16 resting subjects, performing apnea in air and apnea with face immersion in cold water (10 degrees C). Duration of apneas were predetermined to be identical in both conditions (average: 145
The aim of this study was to evaluate treatment results for Hodgkin lymphoma (HL) patients younger than 60 yr in stage IIB, treated according to the Swedish National Care Programme. The intention was also to identify specific subgroups depending on the number of negative prognostic factors the patients have, in order to optimise and differentiate future treatment. In total, 99 patients with HL sta
