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Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice

Neutrophil migration across infected mucosal surfaces is chemokine dependent, but the role of chemokine receptors has not been investigated. In this study, chemokine receptors were shown to be expressed by epithelial cells lining the urinary tract, and to play an essential role for neutrophil migration across the mucosal barrier. Uroepithelial CXCR1 and CXCR2 expression was detected in human urina

Lysozyme-water interactions studied by sorption calorimetry

Hydration of hen egg white lysozyme was studied by using the method of sorption calorimetry at 25, 40, and 50degreesC. Desorption calorimetric measurements were performed at 25 and 40degreesC. The activity of water and partial molar enthalpy of mixing of water were determined as functions of water content. Hydration of lysozyme occurs in four steps: slow penetration of water into the protein-prote

Plum-pudding gels as a platform for drug delivery: Understanding the effects of the different components on the diffusion behavior of solutes

The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The eff

Assessment and analysis of housing accessibility: adapting the environmental component of the housing enabler to United States applications.

The home environment is a primary context for daily activities, especially among older adults and persons with disabilities. Functional and age-related decline can generate problems in relation to certain environmental features, necessitating modifications or other provisions of support. The determination of appropriate home interventions is best served using a person–environment (P–E) fit approac

The GARD assay for assessment of chemical skin sensitizers.

Allergic contact dermatitis is a skin disease caused by an immunologic reaction to low molecular weight compounds, so called haptens. These substances are commonly present in products used by humans in daily life, such as in cosmetics and fragrances, as well as within chemical industry and in pharmaceuticals. The frequent usage of these compounds in different applications has led to increasing inc

Mediatization at the Margins : Cosmopolitanism, Network Capital, and Spatial Transformation in Rural Sweden

The significance of mediatization in countryside settings is an under-researched topic in media studies. In this paper, based on qualitative fieldwork carried out in two rural areas in Sweden, we study how mediatization integrates the prospects of cosmopolitan social change. The current phase of the mediatization process, which imposes a more dynamic register of networked communication, nourishes

Unintelligent Design: A Discussion of Steve Fuller's Dissent over Descent

In this discussion, Steve Fuller's book Dissent over Descent is criticized mainly because he draws conclusions from wishful thinking and uses ancient and medieval scientists as well as theologians in his efforts to invalidate the theory of evolution. He is also criticized for drawing universal conclusions from a Eurocentric version of history. If science and technology studies is to regain its rep

Transnational Actors in Global Governance: Patterns, Explanations, and Implications

The volume analyzes the reasons behind, and consequences of, the growing involvement of transnational actors in established international institutions. It provides comparative analyses of varying international organizations and issue-areas. Combining normative democratic theory and empirical research, it offers innovative interpretations of the democratic legitimacy of current arrangemants.

The role of input frequency in article acquisition in early child Swedish

This paper investigates patterns of article use in monolingual early child Swedish and in child-directed adult speech. Article omissions in the adult data are found to be more widespread than previously assumed, especially articleless, ‘bare’ singular count nouns (e.g. sten ‘stone’ instead of en sten ‘a stone’) and article omissions in doubly determined nominals (e.g. lilla tummen (little thumb-th