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The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside ingested material that shape the chronically active intestinal immune system from early life to maintain the integrity of the gut epithelial barrier. In health, the response is intricately balanced to provide active protection against pathogen invasion whilst tolerating food and avoiding inflammation. B cells are c

This review addresses tilt-testing methodology by searching the literature which reports timing of asystole and loss of consciousness (LOC). Despite the Italian protocol being the most widely adopted, its stipulations are not always followed to the letter of the European Society of Cardiology guidelines. The discrepancies permit reassessment of the incidence of asystole when tilt-down is early, im

Social media has opened up a new tactical front for political campaigns, and the 2017 General Election showed how citizens – armed with smartphones, computers, and tablets – actively enlisted their support in the online electoral battleground. In this report, we look at how Labour supporters leveraged the platform-specific features of different social media to widely promote their favored candidat

BACKGROUND: Coarctation of the aorta coexists with other cardiac anomalies and has long-term complications, including recoarctation, which may require intervention after the primary coarctation repair. This study aims to clarify the prevalence of and risk factors for interventions related to the coarctation complex as well as late mortality in a large contemporary patient population. METHODS AND R

The authors of this paper reinvestigate the remains of the Basilica Sempronia, situated below the Imperial Basilica Julia in Rome. By combining the information from the original excavation with a new 3D digital documentation, new observations are made and previous interpretations reassessed. The present remains are discussed in relation to the contemporary built environment, as well as to precedin

Objective: To evaluate asynchronous digital visits (eVisits) with regard to digital communication, clinical decisionmaking,and subsequent care utilization in the digital era of primary care in Sweden.Methods: A mixed-methods approach was adopted across the various papers in the thesis, with all studiesevaluating the eVisit platform Flow in various clinical contexts.- Paper I was a comparative stud

Cancer invasion and metastasis are known to be potentiated by the expression of aquaporins (AQPs). Likewise, the expression levels of AQPs have been shown to be prognostic for survival in patients and have a role in tumor growth, edema, angiogenesis, and tumor cell migration. Thus, AQPs are key players in cancer biology and potential targets for drug development. Here, we present the single-partic

An electrochemiluminescence technique was used to develop versatile and sensitive assay strategies for determination of seroreactivities against biologically important cytomegalovirus neutralization epitopes expressed on glycoprotein B. Indirect binding assays showed wide linear assay ranges and revealed that serum samples diluted in parallel with a monoclonal antibody-based standard, simplifying

Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of di

Popular Abstract in Swedish Komplementsystemet ingår i vårt naturliga immunförsvar och bidrar till det förvärvade immunförsvaret bl. a. genom att aktiveras av specifika antikroppar. Komplementsystemets viktigaste skyddsfunktioner är att försvara oss mot bakteriella infektioner, förhindra uppkomst av autoimmuna sjukdomar genom att eliminera immunkomplex och döende celler samt att fungera som en för