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The impact of obstructive sleep apnea (OSA) and positive airway pressure (PAP) treatment on COVID-19 severity is unclear. In this population-based, nationwide study using multi-register data, we aimed to assess if OSA is a risk factor for COVID-19 severity and how adherence to PAP treatment and clinical characteristics affect the risk. Swedish residents with COVID-19 infection January 2020–May 202

With two centuries of forestry, natural forests in boreal Sweden are rare and strongly fragmented. Hence, restoration aiming to improve conditions for forest biodiversity is needed. However, to ensure landscape connectivity – where to restore is a critical concern.Our study objective was to identify connectivity forest that through restoration support connectivity and biodiversity. The study area

Magnesium chelatase inserts Mg2+ into protoporphyrin IX and is the first unique enzyme of the chlorophyll biosynthetic pathway. It is a heterotrimeric enzyme, composed of I- (40 kDa), D- (70 kDa) and H- (140 kDa) subunits. The I- and D-proteins belong to the family of AAA(+) (ATPases associated with various cellular activities), but only I-subunit hydrolyses ATP to ADP. The D-subunits provide a pl

Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

Adult neurogenesis is impaired in the hippocampus of transgenic R6 mouse models of Huntington's disease (HD). The phenotypes of R6 transgenic mice mimic several symptoms and signs of the disease (Li et al., 2005). They exhibit neurological and endocrine changes resembling some symptoms seen in humans. The reduction in neurogenesis is only apparent in the dentate gyrus as the number of newborn neur

The essential protein Cdc13p binds the single-stranded telomeric 3' overhangs in Saccharomyces cerevisiae and takes part in the regulation of telomere length. The DNA-binding domain (DBD) of Cdc13p is structurally established by an oligonucleotide/oligosaccharide-binding (OB)-fold domain. The sequence homolog in Saccharomyces castellii (scasCDC13) was characterized previously, and the full-length

This thesis explores the impact of medical migration on the healthcare crisis in East Africa. With a qualitative research design of ten semi-structured interviews it shall help to understand the relationship between medical migration and the healthcare crisis in East Africa. Accordingly, by interviewing doctors with ties to East Africa and relevant experiences for the topic of study, the following

The number of international students in higher education is steadily increasing, so their experiences in the new environment is a topic gaining more and more interest from academics (Wu & Hammond, 2011). The current research suggests a model for determining international students’ happiness. The determining factors in the hypothesized model are university satisfaction, residential satisfaction

‘Rewilding’, or the return of degraded lands to a state of ‘wilderness’, is a bold attempt to resolve the world’s ecological challenges. It however does not address the division between nature and society, which lies at the core of the issues. According to Marshall Sahlins (1972) and Nurit Bird-David (1992), indigenous people relate to ‘nature’ in a markedly different way than Westerners. Capturin

Gold mining causes various negative social and environmental impacts in countries of extraction like Colombia. Voluntary and legal efforts to tackle these challenges have recently increased in Europe. To understand the complex supply chain and the impact of the newly evolved governance structures better, more research is needed. Based on a literature review and interviews, I identify important Eur

The future role of AI in healthcare is largely seen as positive, inevitable, necessary, and driven by the private sector. These dominant narratives obscure decision-making about these future applications, with little room for political scrutiny, or public participation. Public, and private resources, are being funnelled to support various AI health technologies. By prioritising some and not others

Purpose: A pilot study to identify bacterial biofilm in the lacrimal sacs of patients with chronic dacryocystitis, and in patients with epiphora but without discharge, using scanning electron microscopy. Methods: Five patients: two with nasolacrimal duct obstruction without dacryocystitis, and three with dacryocystitis refractory to antibiotics, underwent external dacryocystorhinostomy. One contro

Background: The classic Bernard-Soulier syndrome (BSS) is a rare inherited thrombocytopenia (IT) associated with severe thrombocytopenia, giant platelets, and bleeding tendency caused by homozygous or compound heterozygous variants in GP1BA, GP1BB, or GP9. Monoallelic BSS (mBSS) associated with mild asymptomatic macrothrombocytopenia caused by heterozygous variants in GP1BA or GP1BB may be a frequ

The polymerization of amino acids into proteins occurs on ribosomes, with the rate influenced by the amino acids being polymerized. The imino acid proline is a poor donor and acceptor for peptide-bond formation, such that translational stalling occurs when three or more consecutive prolines (PPP) are encountered by the ribosome. In bacteria, stalling at PPP motifs is rescued by the elongation fact

Understanding the role of technology characteristics and the context in the diffusion of new energy technologies is important for assessing feasibility of climate mitigation. We examine the historical adoption of nuclear power as a case of a complex large scale energy technology. We conduct an event history analysis of grid connections of first sizable commercial nuclear power reactors in 79 count