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This paper describes a driving simulator trial to evaluate driver reactions to a number of alternative information/ warning modes of a multi-modal system for the “safe speed and safe distance” concept. In 2006, eight Human Machine Interaction alternatives, consisting of a combination of visual, haptic and auditory modes were used alternatively to give information/warning to the driver on safe spee
Aim: To investigate the impact of classical coronary heart disease (CHD) risk factors on the development of future erectile dysfunction (ED). Methods and results: A total of 830 randomly selected subjects were included. Baseline CHD risk factors were evaluated in relation to ED (evaluated by the International Index of Erectile Function-5 questionnaire) 25 years later. At follow-up, 499 men (60%) h
Background: Congenital heart disease (CHD) is the most common organ anomaly in humans affecting approximately 1:125 newborns worldwide. Early diagnosis enables postnatal stabilisation and may improve outcomes, especially in critical CHD, in which the circulation is dependent on patency of the arterial duct. Detection of CHD in newborns remains incomplete and current screening programs do not aim t
Recent studies have demonstrated that the transcription factor hepatocyte nuclear factor 4α (HNF4A) drives epithelial differentiation in the renal proximal tubules (PTs) and is critical for maintaining a mature PT phenotype. Furthermore, HNF4A down-regulation has been observed following kidney injury in mouse models. The aim of the present work was to investigate the role of HNF4A during acute and
AIMS/HYPOTHESIS: The aim of this work was to explore associations between type 1 diabetes progression from stages 1 or 2 to stage 3 and interacting ligand-receptor complexes of HLA class I (HLA-I) and KIR gene products.METHODS: Applying next-generation sequencing technology to genotype HLA-I genes (HLA-A, -B, -C) and KIR genes (KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5, KIR2DS1, KIR2DS2, KIR2DS3
One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are ca
The Gaussian phase distribution approximation enables analysis of restricted diffusion encoded by general gradient waveforms but fails to account for the diffraction-like features that may occur for simple pore geometries. We investigate the range of validity of the approximation by random walk simulations of restricted diffusion in a cylinder using isotropic diffusion encoding sequences as well a
Investigating metal-semiconductor interfaces is crucial for enabling ultra-thin film growth and tuning the electronic properties. Here we have studied the atomic mechanism of Bi incorporation into the surface of InSb, the III-V semiconductor with the largest spin-orbit coupling, using surface science techniques and theoretical modeling. Bi deposition onto Sb-terminated InSb(111) surfaces at elevat
A search for long-lived particles (LLPs) using Formula Presented of Formula Presented collision data with Formula Presented recorded by the ATLAS experiment at the LHC is presented. The search targets LLPs with masses between 5 and 55 GeV that decay hadronically in the ATLAS inner detector. Benchmark models with LLP pair production from exotic decays of the Higgs boson and models featuring long-li
Although many efforts have been made to eliminate barriers in public transport worldwide, research shows that public transport is still often perceived as challenging, inconvenient, and inaccessible for many people with disabilities. A growing body of research points to several issues, relating to the spatial and temporal distribution of public transport, affordability, safety, and social barriers
BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease.PURPOSE: To explore if increased l
Date palm oases in North Africa have historically supported agriculture through indigenous irrigation techniques such as foggaras and tabias, made possible by a relatively stable water supply. However, the sustainability of these systems is increasingly threatened by irrational water use, climate change and environmental resources degradation. In response to these challenges, we introduced and eva
The effects of possible climate changes on a cold attic performance are considered in this work. The hygro-thermal responses of the attic to different climate data conditions are simulated using a numerical model, which has been made using the IBPT. Cold attic, which is the most exposed part of the building to the environment, is classified as a risky construction in Sweden. Mould growth on intern
Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov
Background: The role of cystectomy in synchronous oligometastatic bladder cancer is unclear. Objective: To describe a population-based consecutive cohort with primary oligometastatic bladder cancer (M1a or M1b) treated with curative intent. Methods: Twenty consecutive patients with primary stage M1a or M1b bladder cancer subjected to induction chemotherapy and radical cystectomy 2013–2024 in the S
Purpose: To define the curriculum content for two interactive learning courses on age-related macular degeneration (AMD): (1) an advanced course tailored for general ophthalmologists and (2) a basic course for non-ophthalmologist healthcare staff. This initiative aims to establish a national consensus on the educational framework for AMD management among general ophthalmologists in Denmark. Method
BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl
This chapter gives an introduction to the European Research Infrastructure Consortium (ERIC) – a European Union (EU) policy tool introduced in 2009 with the purpose to set up and operate collaborative Research Infrastructures by granting them a legal personality and qualities of an international organization. The shared responsibility between the member states and the EU in the research and innova
SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characte
BACKGROUND: Epidemiologic studies have linked transportation noise to increased morbidity and mortality, particularly for cardiovascular outcomes. However, studies investigating metabolic outcomes such as diabetes are limited and have focused only on noise exposures estimated for the loudest residential façade.OBJECTIVES: We aimed to examine the influence of long-term residential exposure to trans
