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Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen
Background: Negative pressure wound therapy (NPWT) has remarkable effects on the healing of poststernotomy mediastinitis. Foam is presently the material of choice for NPWT in this indication. There is now increasing interest in using gauze, as this has proven successful in the treatment of peripheral wounds. It is important to determine the effects of NPWT using gauze on heart pumping function bef
Abstract Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery, with focus on language and memory functions. Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the s
The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and A
Background and purpose The Scandinavian Sarcoma Group (SSG) XIV protocol is based on experience from previous SSG trials and other osteosarcoma intergroup trials, and has been considered the best standard of care for patients with extremity localized, non-metastatic osteosarcoma. We analyzed the outcome in 63 consecutive patients. Patients and methods From 2001 through 2005, 63 patients recruited
Objective. Secondary hyperparathyroidism (SHPT) is a common problem among patients with chronic kidney disease (CKD) on haemodialysis. This study was conducted to assess the use, effectiveness and safety of intravenous paricalcitol in haemodialysis patients with various degrees of SHPT. Material and methods. This observational, multicentre, prospective study was conducted in 14 Swedish dialysis ce
Cell replacement therapy of neurodegenerative disorders aims to substitute the degenerating cells with new functional neurons. Clinical trails with patients suffering from Parkinson’s or Huntington’s disease have generated proof-of-principle results that neural precursors taken from the developing human brain can survive upon grafting to the diseased brain and provide long-lasting symptomatic reli
This study investigates several commercial selective catalytic reduction (SCR) catalysts (A–E) for application in a high-temperature (approximately 525 °C) and high-concentration (5000 ppm NO) system in combination with CO2 capture. The suggested process for removing high concentrations of NOx seems plausible and autothermal operation is possible for very high NO concentrations. A key property of
Issue of study: Knowledge management is recognised as an essential part of company strategy, with the potential to generate significant competitive advantage. The theoretical basis of knowledge management is well developed, however the practical implementation is not well adapted with regards to construction organisations. More research with a practical perspective regarding knowledge management
Problem definition: Supply chain segmentation is a topic which in later years has received increasing attention from supply chain managers of companies in industrial settings. To members of the supply chain research community the ideas and theoretical contributions underlying the concept of supply chain segmentation are hardly new, but have evolved ever since the beginning of the 1990s. However, a
Som ett alternativ till att implementera mjukvaran in-house är det möjligt att hyra mjukvara som en tjänst, detta kallas för Software as a Service (SaaS). SaaS ställer nya krav på leverantör och kund då de ställs inför nya risker och möjligheter. Efter en litteraturgenomgång har vi identifierat dessa och funnit att vissa faktorer betraktas både som en möjlighet och risk. De faktorer som påstås
Purpose: The purpose of this thesis is to develop a theoretical framework that enables a company to measure the success of an initiative that migrates customers from one channel to another, in order to improve or upgrade the way of handling customer support between the company and its end customers. Methodology: The strategy for this thesis was to carry out an iterative case study - theory-led by
Climate change places pressure on rural land in terms of carbon sequestration, biomass for substitution and adaptation of crops. Land use can both positively and negatively influence the runoff regime, therefor a catchment perspective is important when developing climate strategies. This is also important with respect to flood-risk that will increase with climate change. Here I investigate if ther
Purpose: This master thesis aims to understand how the development of the leading FM companies will influence upon the service strategy in Crawford Sweden. Design/approach: Literature review of published work concerning FM along with interviews with a range of people within Crawford and in the FM business. Research limitations: Owing to constraint of time, the authors have had to make some delimit
A detailed sedimentological study was made on six section walls in the Tvärkroken gravel pit, Idre, west-central Sweden. Based on sediment characteristics, three sedimentary units, units 1-3, were identified. The lowest unit, unit 1, was formed by deposition from sediment-loaded underflows into a stagnant basin. A gradual decrease in water depth is indicated in the upper part of this unit. Post-de
Long time series of satellite remotely sensed Normalized Difference Vegetation Index (NDVI) as an indicator of vegetation greenness can be used in a broad range of research topics such as climate change, vegetation dynamics and desertification monitoring. The first phase of this study tests a practical method using Hyperion imagery onboard on Earth Observing-1 (EO1) spacecraft for simulation of MO
The aim of this doctoral thesis is to contribute to the debate on the importance of diet and disease in explaining the mortality decline and the general literature of the long-term effects of early life conditions. Using individual-level data from Southern Sweden for 1813 to 1968, this work measures the impacts of grain prices during the foetal stage and infant mortality rates during the year of b
Background: With an increased life expectancy for the general population as well as for those ageing with chronic diseases, there are major challenges to the affected individuals and their families, but also to health care and societal planning. Most important, an increasing proportion of older people remain living in their ordinary homes despite health decline and disability. However, little is k
